Arquivos Brasileiros de Endocrinologia e Metabologia 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Association of leptin levels with pathogenetic risk of coronary heart disease and stroke: a meta-analysis
Conclusion There was a significant association of leptin with pathogenetic risk of CHD and stroke, and raised leptin levels could significantly increase the pathogenetic risk of CHD. Objetivo O objetivo desta metanálise foi investigar a associação entre os níveis de leptina e o risco patogenético de doença arterial coronariana e acidente vascular cerebral. Materiais e métodos Foram identificados estudos nas bases de dados PubMed, Embase e Springer Link sem restrição quanto à língua. A razão de chances (OR) e os intervalos de confiança de 95% correspondentes (95% CI) foram usados como índices de efeitos....
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - December 11, 2014 Category: Endocrinology Source Type: research
Should a family history of papillary thyroid carcinoma indicate more aggressive therapy in patients with this tumor?
Conclusion The treatment usually recommended for patients with PTC does not need to be modified in the presence of a family history of this tumor if no factors indicating a poor prognosis are present (tumor ≤2 cm, non-aggressive histology, no extensive extrathyroid invasion or important lymph node involvement, complete tumor resection, no evidence of persistent disease after surgery). Objetivo Avaliar se a terapia atualmente recomendada para o carcinoma papilífero de tireoide (CPT) sem fatores clássicos de pior prognóstico é efetiva também nos casos em que existe história familiar deste tumor. Sujeitos e método...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - December 11, 2014 Category: Endocrinology Source Type: research
Screening for acromegaly in adult patients not reporting enlargement of the extremities, but with arterial hypertension associated with another comorbidity of the disease
Conclusion In patients with arterial hypertension without known pituitary disease, acromegaly is unlikely in the absence of enlargement of the extremities. Objetivo Determinar o valor do rastreamento de acromegalia em pacientes adultos sem aumento de extremidades, mas com hipertensão arterial associada a pelo menos uma outra comorbidade da doença. Sujeitos e métodos Pacientes vistos por clínicos em unidades primárias de saúde foram avaliados. Entre pacientes sem aumento de extremidades, aqueles com hipertensão arterial diagnosticada recentemente e associada a pelo menos uma outra comorbidade foram selecionados...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - December 11, 2014 Category: Endocrinology Source Type: research
Sitting-height measures are related to body mass index and blood pressure levels in children
Conclusion Measures of SH are strongly associated with BMI and BP in children, although the association between SH and BP is probably dependent on the association of both those variables with BMI. This is (an) important information for correct interpretation of SH values in children. Objetivo A altura sentada (sitting height, SH) é um importante parâmetro na avaliação de crianças com distúrbios do crescimento e da puberdade. Além disso, tem sido vista como um marcador de risco cardiovascular, aumentado em adultos com pernas relativamente curtas. O objetivo deste estudo foi avaliar a relação entre proporções c...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - December 11, 2014 Category: Endocrinology Source Type: research
Evaluation of urinary N-acetyl-beta-D-glucosaminidase as a marker of early renal damage in patients with type 2 diabetes mellitus
Conclusions The increase of urinary NAG at the microalbuminuria stage of diabetic nephropathy (DN) suggests that tubular dysfunction is already present in this period. The significant positive association between urinary NAG excretion and ACR indicates the possible clinical application of urinary NAG as a complementary marker for early detection of DN in T2DM. Objetivo Avaliar a utilidade clínica da excreção urinária da N-acetil-beta-D-glucosaminidase (NAG) para a detecção de dano tubular precoce no diabetes melito tipo 2 (DM2). Sujeitos e métodos Foram estudados trinta e seis pacientes com DM2 que se dividira...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - December 11, 2014 Category: Endocrinology Source Type: research
Leptin replacement therapy for the treatment of non-HAART associated lipodystrophy syndromes: a meta-analysis into the effects of leptin on metabolic and hepatic endpoints
The clinical manifestations of lipodystrophy syndromes (LS) are hypoleptinemia, hyperglycemia, insulin resistance, dyslipidemia and hepatic steatosis. Leptin replacement therapy (LRT) is effective at improving these pathologies. Currently, there are no data compiling the evidence from the literature, and demonstrating the effect of LRT in LS patients. A systematic review of the MEDLINE and Cochrane Library databases was conducted to identify studies assessing the effect of LRT on metabolic and hepatic endpoints in patients with LS not associated with highly active antiretroviral therapy (HAART) use. Standardized mean diffe...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - December 11, 2014 Category: Endocrinology Source Type: research
Thyrotoxic hypokalemic periodic paralysis in patients of African descent
A paralisia periódica hipocalêmica tireotóxica (PPHT) é uma urgência endocrinológica caracterizada por ataques recorrentes de fraqueza muscular, associados à hipocalemia e à tireotoxicose. Essa patologia ocorre mais frequentemente em pacientes do sexo masculino, de origem asiática, sendo rara sua apresentação em pessoas de ascendência africana. O caso descrito mostra um paciente afrodescendente que apresentou tetraparesia associada à hipocalemia. Durante esse episódio foi realizado o diagnóstico de hipertireoidismo. A PPHT, embora rara, é potencialmente letal. Portanto, em casos de crises de paresias fláci...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - November 4, 2014 Category: Endocrinology Source Type: research
A rare case of a parathyroid adenoma inside a parathyroid cyst
We report a case of functional PC, describing its diagnostic and therapeutic approach.Os cistos de paratireoide (PCs) são lesões raras, localizadas no pescoço e na região do mediastino anterior. A grande maioria é não funcionante, apresentando-se como lesões cervicais nodulares. PCs não funcionantes de grandes dimensões podem se manifestar com sintomas compressivos. Raramente, PCs produzem quantidades excessivas de hormônio da paratireoide (PTH), o que resulta em hiperparatiroidismo primário. Relatamos um caso de PC funcional, descrevendo sua abordagem diagnóstica e terapêutica. (Source: Arquivos Brasileiros d...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - November 4, 2014 Category: Endocrinology Source Type: research
Maturity onset diabetes of young type 2 due to a novel de novo GKC mutation
Maturity Onset Diabetes of Young (MODY) is a heterogeneous group of monogenic disorders that result in β-cell dysfunction, with an estimated prevalence of 1%-2% in industrialized countries. MODY generally occurs in non-obese patients with negative autoantibodies presenting with mild to moderate hyperglycemia. The clinical features of the patients are heterogeneous, depending on the different genetic subtypes. We pretend to report a case of MODY type 2 caused by a novel de novo CGK mutation, highlighting the importance of the differential diagnosis in pediatric diabetes. A 13-year-old, healthy and non-obese girl was admitt...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - November 4, 2014 Category: Endocrinology Source Type: research
Ten-year evaluation of a Neonatal Screening Program for Congenital Adrenal Hyperplasia
Conclusions The incidence of CAH was 1 case to 14,967 live newborns. Collection of the first sample occurred outside the recommended time, resulting in delays in treatment onset. Objetivo Avaliar o Programa de Triagem Neonatal da Secretaria de Estado da Saúde de Santa Catarina (PTN-SES/SC) em relação à hiperplasia adrenal congênita (HAC) e fornecer subsídios que possibilitem seu aperfeiçoamento. Sujeitos e métodos Estudo descritivo e retrospectivo de 748.395 crianças triadas no período de janeiro de 2001 a dezembro de 2010, sendo analisados a cobertura do PTN-SES/SC, a prevalência da HAC, a idade na coleta...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - November 4, 2014 Category: Endocrinology Source Type: research
Technical and functional aspects of catheterization of inferior petrosal sinuses in ACTH dependent Cushing’s syndrome
Conclusion The catheterization of IPS, despite being an invasive technique, is a safe procedure. The objectives can be done properly in most cases. When well indicated, this procedure remains the gold standard in distinguishing the ectopic form to pituitary source in Cushing’s syndrome. (Source: Arquivos Brasileiros de Endocrinologia e Metabologia)
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - November 4, 2014 Category: Endocrinology Source Type: research
Impairment of muscle vasodilation during mental stress in women with subclinical hypothyroidism
Conclusion Women with SH have reduced muscle vasodilatatory response during mental stress. (Source: Arquivos Brasileiros de Endocrinologia e Metabologia)
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - November 4, 2014 Category: Endocrinology Source Type: research
The effect of weight reduction on antioxidant enzymes and their association with dietary intake of vitamins A, C and E
Conclusions Ten percent weight reduction can have a significant role in increasing antioxidant enzymes activities, especially glutathione reductase, and catalase enzymes in obese women. However, it is important to take into consideration a balanced amount of certain nutrients while administering a diet with limited energy. Objetivo Nosso objetivo foi avaliar os efeitos da perda de peso sobre as enzimas antioxidantes de eritrócitos, e a relação destas com a ingestão das vitaminas A, E e C. Sujeitos e métodos Foram coletadas informações gerais e medidas antropométricas, registro alimentar de três dias e amostr...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - November 4, 2014 Category: Endocrinology Source Type: research
Zinc transporter 8 autoantibodies in patients with type 1 diabetes from a multiethnic population and their first degree relatives
Conclusions ZnT8A is observed in non-Caucasian patients with T1D, even years after the disease onset, as well as in their FDR. In those, there was an overlap between ZnT8A and other T1D antibodies. ZnT8A was associated with PTPN22 polymorphisms. Further longitudinal studies are necessary to elucidate the importance of these findings in the natural history of T1D patients with multiethnic background. Objetivo Os autoanticorpos transportadores de zinco 8 (ZnT8A) foram pouco estudados em indivíduos não caucasianos. Nosso objetivo foi investigar a prevalência de autoanticorpos ZnT8 em pacientes com T1D e seus parentes de...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - November 4, 2014 Category: Endocrinology Source Type: research
Is it necessary to increase the dose of levothyroxine in patients with hypothyroidism who use omeprazole?
Conclusion Omeprazole in the dosage of 20 or 40 mg/day does not interfere in a clinically relevant manner in the treatment of patients with hypothyroidism that was previously under control. Objetivo Acredita-se que o pH gástrico possa interferir na absorção de levotiroxina. O omeprazol, ao inibir a secreção de ácido gástrico, poderia interferir no controle do hipotireoidismo em pacientes em uso de levotiroxina de forma dose-dependente. O presente estudo tem como objetivo investigar essa hipótese. Sujeitos e métodos Vinte e um pacientes em uso de dose estável de levotiroxina por no mínimo um ano foram inclu...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - November 4, 2014 Category: Endocrinology Source Type: research
