Arquivos Brasileiros de Endocrinologia e Metabologia This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Response to sorafenib treatment in advanced metastatic thyroid cancer
Conclusion: These data suggest a possible role for sorafenib in the treatment of progressive metastatic DTC. Adverse event are usually manageable, but severe ones may appear and these patients should be strictly controlled.Objetivo: Investigar a eficácia do sorafenibe no carcinoma de tireoide metastático progressivo e refratário à iodoterapia.Sujeitos e métodos: Estudo observacional do efeito do sorafenibe off-label administrado 400 mg duas vezes ao dia. A duração da terapia foi de 12 ± 3 meses (variação de 6-16 meses).Resultados: Oito pacientes foram incluídos (sete com variante papilífera e um com variante in...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - April 1, 2014 Category: Endocrinology Source Type: research

The value of red blood cell distribution width in subclinical hypothyroidism
Conclusions : RDW levels are correlated with euthyroid and subclinical thyroid status. Notably, RDW is more correlated with subclinical hypothyroidism than the euthyroid status. This study presents the relationship between the RDW levels and thyroid function using TSH level in a large healthy population. Objetivo : Avaliamos a relação entre o hipotireoidismo subclínico e os níveis de distribuição do tamanho dos eritrócitos (RWD) em uma população saudável. Pacientes e métodos : Foram revisadas as fichas médicas de 23.343 sujeitos saudáveis consecutivos. Os sujeitos foram classificados em quatro grupos de ní...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - April 1, 2014 Category: Endocrinology Source Type: research

Comparison between the growth response to growth hormone (GH) therapy in children with partial GH insensitivity or mild GH deficiency
Conclusion: GH therapy increases height in PGHIS and produces similar height effects in MGHD and SGHD.Objetivos: O tratamento com GH é ainda controverso, salvo na deficiência grave de GH (SGHD). O objetivo deste estudo foi comparar a resposta ao tratamento com GH em indivíduos com insensibilidade parcial ao GH (PGHIS) e na deficiência moderada do GH (MGHD) com SGHD.Sujeitos e métodos: Quinze pacientes com PGHIS, 11 com MGHD e 19 com SGHD, seguidos por mais de um ano no Sistema Único de Saúde, foram avaliados antropométrica e laboratorialmente, no início, com um ano de tratamento e na última avaliação (tempo má...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - April 1, 2014 Category: Endocrinology Source Type: research

Challenges and pitfalls in the diagnosis of hyperprolactinemia
The definition of the etiology of hyperprolactinemia often represents a great challenge and an accurate diagnosis is paramount before treatment. Although prolactin levels > 200-250 ng/mL are highly suggestive of prolactinomas, they can occasionally be found in other conditions. Moreover, as much as 25% of patients with microprolactinomas may present prolactin levels < 100 ng/mL, which are found in most patients with pseudoprolactinomas, drug-induced hyperprolactinemia, or systemic diseases. On the other hand, some conditions may lead to falsely low PRL levels, particularly the so-called hook effect, that is an assay ...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - April 1, 2014 Category: Endocrinology Source Type: research

Vitamin D and diabetes mellitus: an update 2013
Vitamin D deficiency and diabetes mellitus are two common conditions and they are widely prevalent across all ages, races, geographical regions, and socioeconomic conditions. Epidemiologic studies have shown association of vitamin D deficiency and increased risk of chronic diseases, such as cancer, cardiovascular disease, type 2 diabetes, and autoimmune diseases, such as multiple sclerosis and type 1 diabetes mellitus. The identification of 1,25(OH)2D receptors and 1-α-hydroxilase expression in pancreatic beta cells, in cells of the immune system, and in various others tissues, besides the bone system support the role of ...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - April 1, 2014 Category: Endocrinology Source Type: research

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(Source: Arquivos Brasileiros de Endocrinologia e Metabologia)
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - January 11, 2014 Category: Endocrinology Source Type: research

Arterial stiffness should be evaluated with other inflammatory markers in patients with subclinical hypothyroidism
Chronic spontaneous urticaria (CSU), defined as the occurrence of spontaneous wheals for more than six weeks, has been associated with autoimmune diseases. Herein, we report the unusual association of CSU, Graves' disease, and premature ovarian failure. Human leukocyte antigen (HLA) studies were performed. A 36-year-old woman presented symptoms and signs of hyperthyroidism for three months. In the same period, the patient complained of widespread urticarial wheals, intensely itchy, and poorly responsive to therapy with antihistaminic agents. Hyperthyroidism was confirmed biochemically, and treatment with methimazole was st...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - January 11, 2014 Category: Endocrinology Source Type: research

The unusual association of Graves' disease, chronic spontaneous urticaria, and premature ovarian failure: report of a case and HLA haplotype characterization
Chronic spontaneous urticaria (CSU), defined as the occurrence of spontaneous wheals for more than six weeks, has been associated with autoimmune diseases. Herein, we report the unusual association of CSU, Graves' disease, and premature ovarian failure. Human leukocyte antigen (HLA) studies were performed. A 36-year-old woman presented symptoms and signs of hyperthyroidism for three months. In the same period, the patient complained of widespread urticarial wheals, intensely itchy, and poorly responsive to therapy with antihistaminic agents. Hyperthyroidism was confirmed biochemically, and treatment with methimazole was st...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - January 11, 2014 Category: Endocrinology Source Type: research

Myxedema coma in a patient with type 1 neurofibromatosis: rare association
We describe a 51-year-old male patient who has discontinued hypothyroidism treatment 10 months earlier and developed lethargy, edema, and cold intolerance symptoms. He also had a previous diagnosis of neurofibromatosis. After admission, he progressed to respiratory insufficiency and coma. The prompt recognition of the condition, thyroid hormone replacement, and management of the complications (hypoventilation, cardiogenic shock associated with swinging heart, adrenal and renal insufficiency and sepsis), resulted in a favorable evolution. (Source: Arquivos Brasileiros de Endocrinologia e Metabologia)
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - January 11, 2014 Category: Endocrinology Source Type: research

Nonadenomatous nonencapsulated thymic parathyroid tissue concomitant with primary hyperparathyroidism due to ectopic parathyroid adenoma
Primary hyperparathyroidism due to ectopic parathyroid adenoma is not infrequent. Primary hyperparathyroidism caused by unusual thymic nonadenomatous nonencapsulated parathyroid tissue has been reported before. Both can cause unsuccessful neck explorations. Here we presented for the first time a patient with hyperparathyroidism due to ectopic parathyroid adenoma concomitant to the presence of thymic nonadenomatous nonencapsulated parathyroid tissue.O hiperparatireodismo primário devido a adenoma ectópico paratireoidiano não é raro. O hiperparatireodismo primário causado por tecido tímico paratireoidiano não edematos...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - January 11, 2014 Category: Endocrinology Source Type: research

Screening for autoimmune polyglandular syndrome in a cohort of patients with type 1 diabetes mellitus
CONCLUSION: Considering APS prevalence and prognosis, the need for APS screening in patients with T1DM is emphasized. Early diagnosis of other autoimmune disorders will enable us to adjust each patient treatment and follow-up. (Source: Arquivos Brasileiros de Endocrinologia e Metabologia)
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - January 11, 2014 Category: Endocrinology Source Type: research

Correlation between iodine urinary levels and pathological changes in thyroid glands
CONCLUSIONS: We conclude that, in this population, there is excess iodine intake, and greater incidence of inflammatory thyroid disease. (Source: Arquivos Brasileiros de Endocrinologia e Metabologia)
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - January 11, 2014 Category: Endocrinology Source Type: research

Static balance in patients presenting diabetes mellitus type 2 with and without diabetic polyneuropathy
CONCLUSIONS: Patients showing DPN demonstrated worse static balance than patients without DPN in the closed eyes condition. Furthermore, the higher the rating in DNE, the stronger the displacement of CoP, which may be associated with higher risk of falls.OBJETIVOS: Comparar o equilíbrio estático em pacientes com diabetes melito tipo 2 (DM2) com ou sem polineuropatia diabética (PND) e correlacionar os escores da escala de Exame da Neuropatia Diabética (EDN) com a média da relação do centro de pressão (CoP). SUJEITOS E MÉTODOS: Vinte pacientes, com idades entre 40 e 54 anos, que apresentavam DM2 e classificados, de ...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - January 11, 2014 Category: Endocrinology Source Type: research

Determinant factors associated with weight loss in adults on diet interventions
CONCLUSIONS: The determinants of > 5% weight loss were fewer visits with a shorter interval between appointments. (Source: Arquivos Brasileiros de Endocrinologia e Metabologia)
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - January 11, 2014 Category: Endocrinology Source Type: research