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Paternal exposure to antirheumatic drugs – What physicians should know Review of the literature
Reproduction capacity and long-term preserved hormonal function are important aspects with big impacts on patients ’ quality of life. Updated information on the interaction between drug therapy and reproductive function is essential when discussing family planning with patients. Currently, limited data is published regarding paternal exposure to different medications. Thus, it may be a challenge for the practi tioner to choose the right therapy for a young male patient. Therefore we reviewed the literature, for effects of antirheumatic drugs on male gonadal function with a focus on spermatogenesis and offspring. (Source:...
Source: Seminars in Arthritis and Rheumatism - January 11, 2018 Category: Rheumatology Authors: M.C. Micu, M. Ostensen, P.M. Villiger, R. Micu, R. Ionescu Source Type: research

A systematic review of precipitating physical and psychological traumatic events in the development of fibromyalgia
The role of physical and psychological trauma precipitating fibromyalgia is often encountered by physicians, yet a proper systematical review of this association is lacking. Literature searches identified 51 studies which examined the association of fibromyalgia with a preceding traumatic event of physical or emotional nature. The overall quality of evidence of studies included, as assessed by the GRADE criteria, was low, however the majority of studies described a significant association between prior physically traumatic events and the onset of chronic widespread pain or fibromyalgia. (Source: Seminars in Arthritis and Rheumatism)
Source: Seminars in Arthritis and Rheumatism - January 10, 2018 Category: Rheumatology Authors: Yarden Yavne, Daniela Amital, Abdulla Watad, Shmuel Tiosano, Howard Amital Source Type: research

Dynamic patterns and predictors of hydroxychloroquine nonadherence among Medicaid beneficiaries with systemic lupus erythematosus
Hydroxychloroquine (HCQ) is the standard of care medication for most SLE patients, however nonadherence is common. We investigated longitudinal patterns and predictors of nonadherence to HCQ in a U.S. SLE cohort of HCQ initiators. (Source: Seminars in Arthritis and Rheumatism)
Source: Seminars in Arthritis and Rheumatism - January 8, 2018 Category: Rheumatology Authors: Candace H. Feldman, Jamie Collins, Zhi Zhang, S.V. Subramanian, Daniel H. Solomon, Ichiro Kawachi, Karen H. Costenbader Source Type: research

Do out-of-pocket costs affect medication adherence in adults with rheumatoid arthritis? A systematic review
For individuals with a chronic condition, long-term management of their medication can be difficult and as a result non-adherence is common among this cohort. In patients with rheumatoid arthritis (RA), the introduction of biologic agents was a revolutionary treatment but the high costs of this medication might limit their utilisation. (Source: Seminars in Arthritis and Rheumatism)
Source: Seminars in Arthritis and Rheumatism - January 8, 2018 Category: Rheumatology Authors: Parvaneh Heidari, Wendy Cross, Kimberley Crawford Source Type: research

Dynamic patterns and predictors of hydroxychloroquine nonadherence among medicaid beneficiaries with systemic lupus erythematosus
Hydroxychloroquine (HCQ) is the standard of care medication for most SLE patients, however nonadherence is common. We investigated longitudinal patterns and predictors of nonadherence to HCQ in a U.S. SLE cohort of HCQ initiators. (Source: Seminars in Arthritis and Rheumatism)
Source: Seminars in Arthritis and Rheumatism - January 8, 2018 Category: Rheumatology Authors: Candace H. Feldman, Jamie Collins, Zhi Zhang, S.V. Subramanian, Daniel H. Solomon, Ichiro Kawachi, Karen H. Costenbader Source Type: research

Do out-of-pocket costs affect medication adherence in adults with rheumatoid arthritis? A systematic review
Rheumatoid arthritis (RA) is a chronic inflammatory disease that often requires long term treatment with multiple medications. However, medication nonadherence can be a major problem in patients with RA, and with the introduction of biologic agents this issue may intensify due to the high costs of these medications. (Source: Seminars in Arthritis and Rheumatism)
Source: Seminars in Arthritis and Rheumatism - January 8, 2018 Category: Rheumatology Authors: Parvaneh Heidari, Wendy Cross, Kimberley Crawford Tags: Systematic review Source Type: research

Prevalence and incidence of psoriatic arthritis: A systematic review and meta-analysis
Psoriatic arthritis (PsA) is a specific form of inflammatory arthritis associated with psoriasis affecting in the same measure men and women but with a consistent geographic variability. Since the burden of PsA frequency has important implications in the definition of the healthcare policies, it is important to measure the frequency of disease in the general population. (Source: Seminars in Arthritis and Rheumatism)
Source: Seminars in Arthritis and Rheumatism - January 6, 2018 Category: Rheumatology Authors: Lorenza Scotti, Matteo Franchi, Antonio Marchesoni, Giovanni Corrao Source Type: research

Systematic review, and meta-analysis of steroid-sparing effect, of biologic agents in randomized, placebo-controlled phase 3 trials for systemic lupus erythematosus
To systematically review, and conduct a meta-analysis of steroid-sparing effect in, phase 3 randomized, placebo-controlled trials of biologic therapies for systemic lupus erythematosus (SLE). (Source: Seminars in Arthritis and Rheumatism)
Source: Seminars in Arthritis and Rheumatism - January 6, 2018 Category: Rheumatology Authors: Shereen Oon, Molla Huq, Timothy Godfrey, Mandana Nikpour Source Type: research

Treatments for giant cell arteritis: Meta-analysis and assessment of estimates reliability using the fragility index
To better communicate the results of randomized controlled trials (RCTs) of giant cell arteritis (GCA), we propose the use of the fragility index (FI), which is an intuitive measure defined as the minimum number of subjects whose status would have to change (e.g., from having the outcome to not) to render a statistically significant result nonsignificant, or vice-versa. (Source: Seminars in Arthritis and Rheumatism)
Source: Seminars in Arthritis and Rheumatism - January 6, 2018 Category: Rheumatology Authors: Alvise Berti, Divi Cornec, Jose R. Medina Inojosa, Eric L. Matteson, M. Hassan Murad Source Type: research

Enthesitis: A hallmark of psoriatic arthritis
To describe the growing importance of enthesitis in patients with psoriatic arthritis (PsA) and discuss the advantages and disadvantages of clinical and imaging methods currently used to assess enthesitis. (Source: Seminars in Arthritis and Rheumatism)
Source: Seminars in Arthritis and Rheumatism - January 6, 2018 Category: Rheumatology Authors: Gurjit S. Kaeley, Lihi Eder, Sibel Z. Aydin, Marwin Gutierrez, Catherine Bakewell Source Type: research

Abatacept in patients with rheumatoid arthritis and interstitial lung disease: A national multicenter study of 63 patients
Interstitial lung disease (ILD) is one of the most serious complications of rheumatoid arthritis (RA). In the present study, we aimed to assess the efficacy of abatacept (ABA) in patients with ILD associated to RA. (Source: Seminars in Arthritis and Rheumatism)
Source: Seminars in Arthritis and Rheumatism - January 6, 2018 Category: Rheumatology Authors: Carlos Fern ández-Díaz, Javier Loricera, Santos Castañeda, Raquel López-Mejías, Clara Ojeda-García, Alejandro Olivé, Samantha Rodríguez-Muguruza, Patricia E. Carreira, Trinidad Pérez-Sandoval, Miriam Retuerto, Evelin C. Cervantes-Pérez, Bryan J. Source Type: research

Membrane attack complex (mac) deposition in lupus nephritis is associated with hypertension and poor clinical response to treatment
To study membrane attack complex in lupus nephritis as a potential biomarker for disease intensity and prognostic indicator for response to treatment. (Source: Seminars in Arthritis and Rheumatism)
Source: Seminars in Arthritis and Rheumatism - January 6, 2018 Category: Rheumatology Authors: Shudan Wang, Ming Wu, Luis Chiriboga, Briana Zeck, H. Michael Belmont Source Type: research

Resolution of remitting seronegative symmetrical synovitis with pitting edema (RS3PE) during Nivolumab therapy for non-small cell lung cancer: a case report.
Immune checkpoint inhibitors have recently received the U.S. Food and Drug Administration and European Medical Agency approval as first and second-line treatment for non-small cell lung cancer (NSCLC) [1 –3]. (Source: Seminars in Arthritis and Rheumatism)
Source: Seminars in Arthritis and Rheumatism - January 6, 2018 Category: Rheumatology Authors: Marco Filetti, Elisabetta Anselmi, Serena Macrini, Francesco Rizzo, Daniela Iacono, Raffaele Giusti, Paolo Marchetti Source Type: research