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Lessons learned from bone marrow failure in systemic lupus erythematosus: Case reports and review of the literature
In the present review, four new cases of bone marrow failure are presented and the potential contribution of systemic lupus erythematosus (SLE) is discussed. Furthermore, a comprehensive literature review of cases of autoimmune myelofibrosis (AIMF), aplastic anemia (AA), and paroxysmal nocturnal hemoglobinuria (PNH) with concurrent SLE aims to allow their direct comparison. Based on a clearer characterization of reported cases and our own experience, diagnostic and therapeutic strategies of these disorders in SLE are proposed based on lessons learned from the present and previous cases. (Source: Seminars in Arthritis and Rheumatism)
Source: Seminars in Arthritis and Rheumatism - December 7, 2017 Category: Rheumatology Authors: Erik Anderson, Bhakti Shah, Anne Davidson, Richard Furie Source Type: research

Guidelines for the conduct of pharmacological clinical trials in hand osteoarthritis: Consensus of a Working Group of the European Society on Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO)
To gather expert opinion on the conduct of clinical trials that will facilitate regulatory review and approval of appropriate efficacious pharmacological treatments for hand osteoarthritis (OA), an area of high unmet clinical need. (Source: Seminars in Arthritis and Rheumatism)
Source: Seminars in Arthritis and Rheumatism - December 7, 2017 Category: Rheumatology Authors: Jean-Yves L. Reginster, Nigel K. Arden, Ida K. Haugen, Francois Rannou, Etienne Cavalier, Olivier Bruy ère, Jaime Branco, Roland Chapurlat, Sabine Collaud Basset, Nasser M. Al-Daghri, Elaine M. Dennison, Gabriel Herrero-Beaumont, Andrea Laslop, Burkhard Source Type: research

Bronchiectasis is highly prevalent in anti-MPO ANCA-associated vasculitis and is associated with a distinct disease presentation
To assess the prevalence of bronchiectasis in a Western cohort with ANCA-positive granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA) and its correlations with disease presentation and outcome. (Source: Seminars in Arthritis and Rheumatism)
Source: Seminars in Arthritis and Rheumatism - December 7, 2017 Category: Rheumatology Authors: Antoine N éel, Alexandra Espitia-Thibault, Pierre-Paul Arrigoni, Christelle Volteau, Marie Rimbert, Agathe Masseau, Christian Agard, Fadi Fakhouri, Renan Liberge, Mohamed Hamidou Source Type: research

Prevalence and risk factors for osteoporosis and fractures in axial spondyloarthritis: A systematic review and meta-analysis
To describe the prevalence of osteoporosis, the prevalence and incidence of fractures, and the frequency of risk factors for low bone mineral density (BMD) in axial spondyloarthritis (Ax-SpA). (Source: Seminars in Arthritis and Rheumatism)
Source: Seminars in Arthritis and Rheumatism - December 7, 2017 Category: Rheumatology Authors: Julio Ram írez, Juan Carlos Nieto-González, Rafael Curbelo Rodríguez, Santos Castañeda, Loreto Carmona Source Type: research

Lessons Learned from Bone Marrow Failure in Systemic Lupus Erythematosus: Case Reports and Review of the Literature
Systemic lupus erythematosus (SLE) is the prototypic systemic autoimmune disease with variable multisystem involvement. Hematologic abnormalities involving multiple cell lineages are common in SLE. Lymphopenia was present in 75% among a large cohort of SLE patients and occurred more frequently than any other criterion used to classify the disease [1]. Anemia is estimated to occur in about 50% of patients [2]. While anemia of chronic disease and iron deficiency are quite common, autoantibody- or complement-mediated autoimmune hemolytic anemia are occasionally encountered [3]. (Source: Seminars in Arthritis and Rheumatism)
Source: Seminars in Arthritis and Rheumatism - December 7, 2017 Category: Rheumatology Authors: Erik Anderson, Bhakti Shah, Anne Davidson, Richard Furie Source Type: research

Guidelines for the conduct of pharmacological clinical trials in hand osteoarthritis: Consensus of a working group of the european society on clinical and economic aspects of osteoporosis, osteoarthritis and musculoskeletal diseases (ESCEO)
To gather expert opinion on the conduct of clinical trials that will facilitate regulatory review and approval of appropriate efficacious pharmacological treatments for hand osteoarthritis (OA), an area of high unmet clinical need. (Source: Seminars in Arthritis and Rheumatism)
Source: Seminars in Arthritis and Rheumatism - December 7, 2017 Category: Rheumatology Authors: Jean-Yves L. Reginster, Nigel K. Arden, Ida K. Haugen, Francois Rannou, Etienne Cavalier, Olivier Bruy ère, Jaime Branco, Roland Chapurlat, Sabine Collaud Basset, Nasser M. Al-Daghri, Elaine M. Dennison, Gabriel Herrero-Beaumont, Andrea Laslop, Burkhard Source Type: research

Evidence of reduced parasympathetic autonomic regulation in inflammatory joint disease: A meta-analyses study
Rheumatoid arthritis (RA) and spondyloarthritis (SpA) are inflammatory joint disorders (IJD) with increased risk of cardiovascular disease (CVD). Autonomic dysfunction (AD) is a risk factor for CVD, and parasympathetic AD is linked to key features of IJD such as inflammation, physical inactivity and pain. Heart-rate variability (HRV) is a marker of cardiac AD. The study objective was to compare parasympathetic cardiac AD, measured by HRV, between patients with IJD and healthy controls, using meta-analysis methodology, and to examine the impact of inflammation, physical inactivity and pain on HRV in IJD. (Source: Seminars i...
Source: Seminars in Arthritis and Rheumatism - December 2, 2017 Category: Rheumatology Authors: Sella A. Provan, Daniela Sch äfer Olstad, Erik E. Solberg, Geir Smedslund, Hanne Dagfinrud Source Type: research

Evidence of reduced parasympathetic autonomic regulation in inflammatory joint disease. A meta-analyses study
Rheumatoid arthritis (RA) and spondyloarthritis (SpA) are inflammatory joint disorders (IJD) with increased risk of cardiovascular disease (CVD). Autonomic dysfunction (AD) is a risk factor for CVD, and parasympathetic AD is linked to key features of IJD such as inflammation, physical inactivity and pain. Heart rate variability (HRV) is a marker of cardiac AD. The study objective was to compare parasympathetic cardiac AD, measured by HRV, between patients with IJD and healthy controls, using meta-analysis methodology, and to examine the impact of inflammation, physical inactivity and pain on HRV in IJD. (Source: Seminars i...
Source: Seminars in Arthritis and Rheumatism - December 2, 2017 Category: Rheumatology Authors: Sella A. Provan, Daniela Sch äfer Olstad, Erik E. Solberg, Geir Smedslund, Hanne Dagfinrud Source Type: research

Concurrence of rheumatoid arthritis and calcium pyrophosphate deposition disease: A case collection and review of the literature
Calcium pyrophosphate deposition disease (CPDD) is arthritis caused by calcium pyrophosphate (CPP) crystal deposition in joints. It is commonly associated with aging as well as a handful of metabolic syndromes. Recent epidemiologic studies suggest a positive association of CPDD and rheumatoid arthritis (RA). Yet how these diseases are related remains unclear. We set out to describe 21 well-characterized patients with both diagnoses. (Source: Seminars in Arthritis and Rheumatism)
Source: Seminars in Arthritis and Rheumatism - November 30, 2017 Category: Rheumatology Authors: Viktoriya Sabchyshyn, Irina Konon, Lawrence M. Ryan, Ann K. Rosenthal Source Type: research

Concurrence of Rheumatoid Arthritis and Calcium Pyrophosphate Deposition Disease: A case collection and review of the literature
Calcium pyrophosphate deposition disease (CPDD) is arthritis caused by calcium pyrophosphate (CPP) crystal deposition in joints. It is commonly associated with aging as well as a handful of metabolic syndromes. Recent epidemiologic studies suggest a positive association of CPDD and rheumatoid arthritis (RA). Yet how these diseases are related remains unclear. We set out to describe 21 well-characterized patients with both diagnoses. (Source: Seminars in Arthritis and Rheumatism)
Source: Seminars in Arthritis and Rheumatism - November 30, 2017 Category: Rheumatology Authors: Viktoriya Sabchyshyn, Irina Konon, Lawrence M. Ryan, Ann K. Rosenthal Source Type: research

Autoimmune arthritis in M énière’s disease: A systematic review of the literature
Successful management of patients with M énière’s disease (MD) involves understanding the pathophysiology of the disease and its comorbidities. The role of autoimmune diseases (AD) in MD remains unclear. The aim of this study was to further investigate the association between MD and AD. Specific goals were to characterize the prevalenc e, distribution, clinical and laboratory findings, and outcomes of autoimmune arthritis (AA) in MD. (Source: Seminars in Arthritis and Rheumatism)
Source: Seminars in Arthritis and Rheumatism - November 29, 2017 Category: Rheumatology Authors: Lisa Caulley, Alexandra Quimby, Jacob Karsh, Azin Ahrari, Darren Tse, Georgios Kontorinis Source Type: research