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Clinical presentation of immune checkpoint inhibitor-induced inflammatory arthritis differs by immunotherapy regimen
This study aimed to characterize clinical phenotypes, IA treatment and response in the largest cohort of patients with ICI-induced IA reported to date. (Source: Seminars in Arthritis and Rheumatism)
Source: Seminars in Arthritis and Rheumatism - February 22, 2018 Category: Rheumatology Authors: Laura C. Cappelli, Julie R. Brahmer, Patrick M. Forde, Dung T. Le, Evan J. Lipson, Jarushka Naidoo, Lei Zheng, Clifton O. Bingham, Ami A. Shah Source Type: research

Low disease activity —irrespective of serologic status at baseline—associated with reduction of corticosteroid dose and number of flares in patients with systemic lupus erythematosus treated with belimumab: A real-life observational study
Low disease activity is a validated target of current systemic lupus erythematosus (SLE) therapy. The aim of this study was to assess the ability of belimumab to achieve low disease activity states in real-life settings. (Source: Seminars in Arthritis and Rheumatism)
Source: Seminars in Arthritis and Rheumatism - February 22, 2018 Category: Rheumatology Authors: Antonis Fanouriakis, Christina Adamichou, Sofia Koutsoviti, Stylianos Panopoulos, Chrysanthi Staveri, Anastasia Klagou, Christina Tsalapaki, Lamprini Pantazi, Styliani Konsta, Clio P. Mavragani, Despoina Dimopoulou, Styliani Ntali, Georgios Katsikas, Kyri Source Type: research

Phenotypic characterization of patients with rheumatologic manifestations of common variable immunodeficiency
Patients with common variable immunodeficiency (CVID) have a higher incidence of rheumatologic disorders. To delineate this clinical association, we investigated the phenotypic features of patients with CVID affected by these conditions. (Source: Seminars in Arthritis and Rheumatism)
Source: Seminars in Arthritis and Rheumatism - February 22, 2018 Category: Rheumatology Authors: Maria J. Gutierrez, Kathleen E. Sullivan, Ramsay Fuleihan, The USIDNET Consortium, Clifton O. Bingham Source Type: research

Predicting eventual development of lupus nephritis at the time of diagnosis of systemic lupus erythematosus
To investigate factors predictive of future lupus nephritis development when systemic lupus erythematosus (SLE) is diagnosed. (Source: Seminars in Arthritis and Rheumatism)
Source: Seminars in Arthritis and Rheumatism - February 22, 2018 Category: Rheumatology Authors: Oh Chan Kwon, Jung Sun Lee, Byeongzu Ghang, Yong-Gil Kim, Chang-Keun Lee, Bin Yoo, Seokchan Hong Source Type: research

Low disease activity - irrespective of serologic status at baseline - associated with reduction of corticosteroid dose and number of flares in patients with systemic lupus erythematosus treated with belimumab: A real-life observational study
Low disease activity is a validated target of current systemic lupus erythematosus (SLE) therapy. The aim of this study was to assess the ability of belimumab to achieve low disease activity states in real-life settings. (Source: Seminars in Arthritis and Rheumatism)
Source: Seminars in Arthritis and Rheumatism - February 22, 2018 Category: Rheumatology Authors: Antonis Fanouriakis, Christina Adamichou, Sofia Koutsoviti, Stylianos Panopoulos, Chrysanthi Staveri, Anastasia Klagou, Christina Tsalapaki, Lamprini Pantazi, Styliani Konsta, Clio P. Mavragani, Despoina Dimopoulou, Styliani Ntali, Georgios Katsikas, Kyri Source Type: research

Measurement properties of patient reported outcome measures for spondyloarthritis: A systematic review
This systematic review aimed to identify studies investigating measurement properties of patient reported outcome measures (PROMs) for spondyloarthritis (SpA), and to evaluate their methodological quality and level of evidence relating to the measurement properties of PROMs. (Source: Seminars in Arthritis and Rheumatism)
Source: Seminars in Arthritis and Rheumatism - February 22, 2018 Category: Rheumatology Authors: Kelly PNG, Yu Heng KWAN, Ying Ying LEUNG, Jie Kie PHANG, Jia Qi LAU, Ka Keat LIM, Eng Hui CHEW, Lian Leng LOW, Chuen Seng TAN, Julian THUMBOO, Warren FONG, Truls OSTBYE Source Type: research

Predictive value of early structural changes on radiographs and MRI for incident clinical and radiographic knee osteoarthritis in overweight and obese women
To determine the predictive value of tibiofemoral (TF), patellofemoral (PF) MRI osteoarthritis (OA) and Kellgren and Lawrence grade 1 (KLG1) for the incidence of knee OA (clinical and/or radiological signs) at 2.5 and 6.5 years follow-up in a high-risk cohort. (Source: Seminars in Arthritis and Rheumatism)
Source: Seminars in Arthritis and Rheumatism - February 22, 2018 Category: Rheumatology Authors: C.B.M. Bijen, J. Runhaar, J.B.M. Rijkels-Otters, E.H. Oei, S.M.A. Bierma-Zeinstra Source Type: research

What is the prevalence of cognitive impairment in lupus and which instruments are used to measure it? A systematic review and meta-analysis
To systematically review the literature on the prevalence of Cognitive Dysfunction (CD) in SLE patients in studies that used a specified neuropsychological instrument. (Source: Seminars in Arthritis and Rheumatism)
Source: Seminars in Arthritis and Rheumatism - February 20, 2018 Category: Rheumatology Authors: Hanan Al Rayes, Chiara Tani, Andrew Kwan, Sherief Marzouk, Kenneth Colosimo, Jorge Medina-Rosas, Ahmed Mustafa, Jiandong Su, Panos Lambiris, Marta Mosca, Zahi Touma Source Type: research

Serum urate as surrogate endpoint for flares in people with gout: A systematic review and meta-regression analysis
The primary efficacy outcome in trials of urate lowering therapy (ULT) for gout is serum urate (SU). The aim of this study was to examine the strength of the relationship between SU and patient-important outcomes to determine whether SU is an adequate surrogate endpoint for clinical trials. (Source: Seminars in Arthritis and Rheumatism)
Source: Seminars in Arthritis and Rheumatism - February 20, 2018 Category: Rheumatology Authors: Lisa Stamp, Melanie B. Morillon, William J. Taylor, Nicola Dalbeth, Jasvinder A. Singh, Marissa Lassere, Robin Christensen Source Type: research

Is abnormal glucose tolerance or diabetes a risk factor for knee, hip, or hand osteoarthritis? A systematic review
Diabetes (DM) and osteoarthritis (OA) are two common co-existing chronic conditions. However, whether this is due to shared risk factors or may differ between joints is unclear. We performed a systematic review to determine whether abnormal glucose metabolism is a risk factor for knee, hip and hand OA, separately, independent of age and obesity. (Source: Seminars in Arthritis and Rheumatism)
Source: Seminars in Arthritis and Rheumatism - February 20, 2018 Category: Rheumatology Authors: Luke P. Dawson, Jessica L. Fairley, Michelle C. Papandony, Sultana Monira Hussain, Flavia M. Cicuttini, Anita E. Wluka Source Type: research

Predictors of hypogammaglobulinemia during rituximab maintenance therapy in rheumatoid arthritis: A 12-year longitudinal multi-center study
Rituximab (RTX) is an anti-CD20 monoclonal antibody that selectively depletes B-cell population. Thus, it presents a potential risk for the development of hypogammaglobulinemia and related infectious events. Our aim was to identify predictors of hypogammaglobulinemia in RA patients long-term treated with RTX. (Source: Seminars in Arthritis and Rheumatism)
Source: Seminars in Arthritis and Rheumatism - February 20, 2018 Category: Rheumatology Authors: G. Boleto, J. Avouac, J. Wipff, M. Forien, M. Dougados, C. Roux, A. Kahan, P. Dieude, Y. Allanore Source Type: research

Cardiovascular disease in ANCA-associated vasculitis: The danger lurking beneath the surface!
We read with great interest the recent article by Bai et al. [1] reporting that, along with traditional risk factors, higher disease activity at baseline also independently predicted cardiovascular events (CVE) and cardiovascular mortality in a large cohort of AAV. We discuss these findings in the light of recent literature. (Source: Seminars in Arthritis and Rheumatism)
Source: Seminars in Arthritis and Rheumatism - February 20, 2018 Category: Rheumatology Authors: Durga Prasanna Misra, Aman Sharma, Vikas Agarwal Source Type: research

What Is the Prevalence of Cognitive Impairment in Lupus and Which Instruments Are Used to Measure It? A Systematic Review and Meta-Analysis
To systematically review the literature on the prevalence of Cognitive Dysfunction (CD) in SLE patients in studies that used a specified neuropsychological instrument. (Source: Seminars in Arthritis and Rheumatism)
Source: Seminars in Arthritis and Rheumatism - February 20, 2018 Category: Rheumatology Authors: Hanan Al Rayes, Chiara Tani, Andrew Kwan, Sherief Marzouk, Kenneth Colosimo, J. Medina-Rosas, A Mustafa, Jiandong Su, Panos Lambiris, Marta Mosca, Zahi Touma Source Type: research

Serum urate as surrogate endpoint for flares in people with gout: a systematic review and meta-regression analysis
The primary efficacy outcome in trials of urate lowering therapy (ULT) for gout is serum urate (SU). The aim of this study was to examine the strength of the relationship between SU and patient-important outcomes to determine whether SU is an adequate surrogate endpoint for clinical trials. (Source: Seminars in Arthritis and Rheumatism)
Source: Seminars in Arthritis and Rheumatism - February 20, 2018 Category: Rheumatology Authors: Lisa Stamp, Melanie B. Morillon, William J. Taylor, Nicola Dalbeth, Jasvinder A. Singh, Marissa Lassere, Robin Christensen Source Type: research