Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

A diet enriched in longer chain omega-3 fatty acids reduced placental inflammatory cytokines and improved fetal sustainability of C57BL/6 mice
Publication date: Available online 1 September 2018Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): O.A Akerele, S.K CheemaAbstractOmega (n)-3 polyunsaturated fatty acids (PUFA) are important regulators of inflammatory response that may impact pregnancy outcome. The effects of breeding chow diets containing n-3 PUFA from either fish oil (FO) or soybean oil (SO) were investigated on tissue fatty acid composition, inflammatory cytokines and pregnancy outcome. Female C57BL/6 mice (7 weeks old) were fed FO or SO diets for 2 weeks before mating and throughout pregnancy. Animals were sacrificed before and...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - September 1, 2018 Category: Lipidology Source Type: research

Editorial Board
Publication date: August 2018Source: Prostaglandins, Leukotrienes and Essential Fatty Acids, Volume 135Author(s): (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA))
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - August 14, 2018 Category: Lipidology Source Type: research

A stable method for routine analysis of oxylipins from dried blood spots using ultra-high performance liquid chromatography–tandem mass spectrometry
In this study, we report the development and validation of a novel system for the quantitation of 21 individual oxylipins from a dried blood spot (DBS) using ultra-high performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS) and stable isotope dilution analysis. Linearity and precision of the method were determined and the stabilities of the 12 most abundant oxylipins were tested during 2 months of storage at room temperature, after being spiked into blood and prepared as DBS on PUFAcoatTM paper. Responses were linear across the concentration range analysed for all oxylipins (r2 values ranged from 0.95...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - August 2, 2018 Category: Lipidology Source Type: research

Moderating effect of plin4 genetic variant on impulsivity traits in 5-year-old-children born small for gestational age
Publication date: Available online 27 July 2018Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Danitsa Marcos Rodrigues, Gisele Gus Manfro, Robert Daniel Levitan, Meir Steiner, Michael Joseph Meaney, Patrícia Pelufo SilveiraAbstractPoor fetal growth is associated with long-term behavioral, metabolic and psychiatric alterations, including impulsivity, insulin resistance and mood disorders. However, the consumption of omega-3 polyunsaturated fatty acid (n-3 PUFA) seems to be protective for this population, improving inhibitory control and behavioral reactivity. We investigated whether the presence o...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - July 28, 2018 Category: Lipidology Source Type: research

Genetic Variant in the 3′-Untranslated Region of the COX2 Gene Is Associated with Type 2 Diabetes: A Hospital-Based Case-Control Study
In this study, we evaluated rs5275 and rs689466 variants located on the COX-2 gene by PCR-RFLP in 100 T2DM patients and 100 control subjects. The interaction among COX2 variants and T2DM was analyzed using appropriate methods. The both variants were in Hardy–Weinberg equilibrium in patients and controls (p>0.05). A significant association was observed for genotype distribution of COX2 rs5275 site between control and T2DM cases (p=0.042). In a dominant model, the cases who had at least one copy of allele C, were at increased risk of T2DM (p=0.016). We found no significant association for the COX2 rs689466 domain by evalua...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - July 27, 2018 Category: Lipidology Source Type: research

Dietary caprylic acid and ghrelin O-acyltransferase activity to modulate octanoylated ghrelin functions: what is new in this nutritional field?
Publication date: Available online 27 July 2018Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Fanny Lemarié, Erwan Beauchamp, Gaëtan Drouin, Philippe Legrand, Vincent RiouxAbstractCaprylic acid (octanoic acid, C8:0) belongs to the class of medium-chain saturated fatty acids (MCFAs). Dairy products and specific oils such as coconut oil are natural sources of dietary caprylic acid. MCFAs display distinct chemico-physical and metabolic properties from those of long-chain saturated fatty acids (LCFAs ≥ 12 carbons) and potential beneficial physiological effects of dietary C8:0 have been studied for...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - July 27, 2018 Category: Lipidology Source Type: research

Acute fish oil supplementation modulates the inflammatory response after strenuous exercise in obese men: a cross-over study
ConclusionAcute supplementation with fish oil attenuates the proinflammatory cytokine response and diminished the DNA damage after strenuous exercise in obese individuals, suggesting a possible protective effect against the exacerbation of systemic damage induced by exhaustive exercise in obese individuals. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA))
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - July 25, 2018 Category: Lipidology Source Type: research

Dietary n-3 but not n-6 fatty acids down-regulate maternal dyslipidemia induced inflammation: A three-generation study in rats
This study addresses the effects of n-3 and n-6 fatty acids in maternal dyslipidemia induced inflammation over three generation in rats. The detailed protocol for animal feeding and mating is described in the methodology. Placenta and fetal liver were isolated on the eighteenth day of gestation and delivered pups after lactation were kept on their maternal diets. Compared to control and experimental groups, high-fat fed rats (HFL) had a higher level of cytokines and eicosanoids in serum (p < 0.05). Liver and uterine expression of cPLA-2, Cox-2, 5-Lox, EP-1, BLT-1, and ICAM-1 were higher (p < 0.05) in HFL gr...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - July 24, 2018 Category: Lipidology Source Type: research

N-docosahexaenoylethanolamine detected in human breast milk
Conclusion: This is the first demonstration of detectable concentrations of synaptamide in human breast milk. Although the attempt to raise the milk DHA content by omega-3 fatty acid supplementation was not successful in the current study, the positive correlation observed between synaptamide and DHA concentration suggests that synaptamide levels in human milk can be raised by proper omega-3 fatty acid supplementation that is known to increase DHA. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA))
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - July 24, 2018 Category: Lipidology Source Type: research

Concentrations of oxidized linoleic acid derived lipid mediators in the amygdala and periaqueductal grey are reduced in a mouse model of chronic inflammatory pain
In this study, we employed a mouse model of chronic inflammatory pain followed by a targeted lipidomic analysis of the animals’ amygdala and periaqueductal grey (PAG) using LC-MS/MS to investigate the effect of chronic inflammatory pain on oxylipin concentrations in these two brain nuclei known to participate in pain sensation and perception. From punch biopsies of these brain nuclei, we detected twelve OXLAMs in both the PAG and amygdala and one arachidonic acid derived mediator, 15-HETE, in the amygdala only. In the amygdala, we observed an overall decrease in the concentration of the majority of OXLAMs detected, while...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - July 24, 2018 Category: Lipidology Source Type: research

WITHDRAWN: The Endocannabinoid System: Overview of an Emerging Multi-faceted Therapeutic Target
Publication date: Available online 11 July 2018Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Dipanjan Chanda, Dietbert Neumann, Jan F.C. GlatzAbstractThe endocannabinoids anandamide (AEA) and 2-arachidonoylglyerol (2-AG) are endogenous lipid mediators that exert protective roles in pathophysiological conditions, including cardiovascular diseases. In this brief review, we provide a conceptual framework linking endocannabinoid signaling to the control of the cellular and molecular hallmarks, and categorize the key components of endocannabinoid signaling that may serve as targets for novel therapeut...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - July 21, 2018 Category: Lipidology Source Type: research

Ischemia-modified albumin: crosstalk between fatty acid and cobalt binding
Publication date: Available online 20 July 2018Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): James P.C. Coverdale, Kondwani Katundu, Amélie I.S. Sobczak, Swati Arya, Claudia A. Blindauer, Alan J. StewartAbstractMyocardial ischemia is difficult to diagnose effectively with still few well-defined biochemical markers for identification in advance, or in the absence of myocardial necrosis. “Ischemia-modified albumin” (IMA), a form of albumin displaying reduced cobalt-binding affinity, is significantly elevated in ischemic patients, and the albumin cobalt-binding (ACB) assay can measure its level...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - July 21, 2018 Category: Lipidology Source Type: research

F2-isoprostanes and fatty acids profile in early pregnancy complicated by pre-existing diabetes
ConclusionsPre-existing diabetes in early pregnancy displays a distinctive F2-isoprostanes profile when compared to other pathologies of pregnancy, such as preeclampsia, as previously assessed in the same cohort. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA))
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - July 20, 2018 Category: Lipidology Source Type: research

Stearidonic Acid Combined with Alpha-Linolenic Acid Improves Lipemic and Neurological Markers in a Rat Model Subject to a Hypercaloric Diet
In this study, we hypothesized that terrestrial plant oils, rich in alpha linolenic acid (ALA) and stearidonic acid (SDA) relative to fish oil, rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), prevent negative effects on cardiovascular and neurological function using a rat model fed a hypercaloric diet. Results showed effects on the FA profile, namely, eicosapentaenoic, EPA, and docosahexaenoic, DHA, levels. There were also effects on neural aspects (cAMP response element-binding protein, CREB, gene expression, at least, doubled) and the pro-inflammatory/anti-inflammatory balance (TNF-α, tumor necrosis ...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - July 20, 2018 Category: Lipidology Source Type: research

Role of metabolic programming in the modulation of microglia phagocytosis by lipids
Publication date: August 2018Source: Prostaglandins, Leukotrienes and Essential Fatty Acids, Volume 135Author(s): A. NadjarAbstractMicroglia phagocytosis is an essential process to maintain lifelong brain homeostasis and clear potential toxic factors from the neuropil. Microglia can engulf cells or part of cells through the expression of specific receptors at their surface and activation of downstream signaling pathways to engulf material. Microglia phagocytosis is finely regulated and is under the dependence of many factors, including environmental cues such as dietary lipids. Yet, the molecular mechanisms implicated are ...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - July 18, 2018 Category: Lipidology Source Type: research