Moderating effect of plin4 genetic variant on impulsivity traits in 5-year-old-children born small for gestational age

Publication date: Available online 27 July 2018Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Danitsa Marcos Rodrigues, Gisele Gus Manfro, Robert Daniel Levitan, Meir Steiner, Michael Joseph Meaney, Patrícia Pelufo SilveiraAbstractPoor fetal growth is associated with long-term behavioral, metabolic and psychiatric alterations, including impulsivity, insulin resistance and mood disorders. However, the consumption of omega-3 polyunsaturated fatty acid (n-3 PUFA) seems to be protective for this population, improving inhibitory control and behavioral reactivity. We investigated whether the presence of the A allele of rs8887 SNP (PLIN4 gene), known to be associated with increased sensitivity to the consumption of n-3 PUFAs, interacts with fetal growth influencing inhibitory control. 152 five-year-old children were genotyped and performed the Stop Signal Task (SSRT). There was a significant interaction between birth weight and the presence of the A allele on SSRT performance, in which lower birth weight associated with poorer inhibitory control only in non-carriers. These results suggest that a higher responsiveness to n-3 PUFAS protects small for gestational age children from developing poor response inhibition, highlighting that optimizing n-3 PUFA intake may benefit this population.

Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - July 28, 2018 Category: Lipidology Source Type: research