Genetic Variant in the 3′-Untranslated Region of the COX2 Gene Is Associated with Type 2 Diabetes: A Hospital-Based Case-Control Study

In this study, we evaluated rs5275 and rs689466 variants located on the COX-2 gene by PCR-RFLP in 100 T2DM patients and 100 control subjects. The interaction among COX2 variants and T2DM was analyzed using appropriate methods. The both variants were in Hardy–Weinberg equilibrium in patients and controls (p>0.05). A significant association was observed for genotype distribution of COX2 rs5275 site between control and T2DM cases (p=0.042). In a dominant model, the cases who had at least one copy of allele C, were at increased risk of T2DM (p=0.016). We found no significant association for the COX2 rs689466 domain by evaluating homozygous, heterozygous, dominant, and recessive models (p>0.05). According to our data, the rs5275 variant of the COX2 in the 3′-UTR may contribute to the etiology or modulate the risk of T2DM, whereas the rs689466 variant of the COX2 gene is not associated with T2DM risk.
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - Category: Lipidology Source Type: research