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Editorial Board
Publication date: May 2019Source: Prostaglandins, Leukotrienes and Essential Fatty Acids, Volume 144Author(s): (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA))
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - May 12, 2019 Category: Lipidology Source Type: research

Relationship of Omega-3 Fatty Acids DHA and EPA with the Inflammatory Biomarker hs-CRP in Children with Sickle Cell Anemia
ConclusionsFindings demonstrate relative deficiencies in HbSS of the anti-inflammatory precursor fatty acids DHA and EPA, which correlates positively with hs-CRP. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA))
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - May 10, 2019 Category: Lipidology Source Type: research

Variants in the CYSLTR2 are associated with asthma, atopy markers and helminths infections in the Brazilian population
ConclusionPolymorphisms in the CYSLTR2 gene are associated with asthma, atopy markers and helminth infection in Brazilian individuals, which may lead to protection or risk for such conditions, however, more studies are needed to evaluate the functional of this variants here in described. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA))
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - May 7, 2019 Category: Lipidology Source Type: research

Changes to breast milk fatty acid composition during storage, handling and processing: a systematic review
Publication date: Available online 1 May 2019Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Chang Gao, Jacqueline Miller, Philippa F. Middleton, Yi-Chao Huang, Andrew J. McPhee, Robert A. GibsonAbstractThis review evaluated the effect of various storage and handling conditions on the fat composition of expressed breast milk (EBM). Three databases PubMed, Embase and Scopus were searched in April 2019 with words from the three key components: human milk, handling process (i.e. storage and/or pasteurization), and fatty acid composition. The comparisons were EBM subjected to handling processes versus ...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - May 2, 2019 Category: Lipidology Source Type: research

Quantitating fatty acids in dried blood spots on a common collection card versus a novel wicking sampling device
Publication date: Available online 2 May 2019Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Jan Gunash, Juan J. Aristizabal-Henao, Ken D. StarkAbstractBlood biomarkers of n-3 polyunsaturated fatty acids can serve as indicators of dietary intake and benefits and/or disease risk. The use of dried blood spots for fatty acid analyses is increasing but most of the reported data is qualitative (relative percentages of total fatty acids). The ability to quantitate concentrations of fatty acids on a common blood spot collection card and a novel wicking device designed to collect 10μL of blood was compare...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - May 2, 2019 Category: Lipidology Source Type: research

Physical fitness is associated with prostaglandin F2α isomers during pregnancy
ConclusionsOverall, higher cardio-respiratory fitness in early pregnancy is associated with enhanced erythrocyte membranes oxidation at 34–37 weeks reflecting a higher oxygen transfer capacity. Also, the most active women experienced lower circulating levels of pro-inflammatory PGF2α in plasma at 34–37 weeks, a marker associated with adverse antenatal inflammation-associated conditions. These results support the practice of physical activity by pregnant women. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA))
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - May 2, 2019 Category: Lipidology Source Type: research

Growth, tolerance, and DHA and ARA status of healthy term infants receiving formula with two different ARA concentrations: Double-blind, randomized, controlled trial
In this study, healthy term infants received study formula through 120 days of age. All study formulas had 17 mg DHA/100 kcal. Investigational formulas had 1) ARA at 25/mg 100 kcal and no added prebiotic blend (ARA-25; n=29) or 2) 34 mg ARA 100/kcal and a prebiotic blend (1:1 ratio; 4g/L) of polydextrose and galactooligosaccharides (PDX/GOS; n=20). The control formula had 34 mg ARA/100 kcal and no added prebiotic blend (Control: n=31). Fatty acids in total RBCs and plasma phospholipids (PPLs) at 120 days and buccal epithelial PLs at 14 and 120 days of age were assessed by capillary column gas chromatography. The calculated...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - May 1, 2019 Category: Lipidology Source Type: research

Dietary docosahexaenoic acid contributes to increased bone mineral accretion and strength in young female Sprague-Dawley rats
Publication date: Available online 22 April 2019Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Zahra Farahnak, Marie Therese Freundorfer, Paula Lavery, Hope A. WeilerAbstractGrowing evidence suggests that docosahexaenoic acid (DHA: 22:6n-3) enhances bone mineral content (BMC) and bone mineral density (BMD) in adulthood and during aging, however the effects during and after sexual maturation are unclear. The aim of this study was to examine the dose-response of BMC, BMD and microarchitectural properties of bone to dietary DHA in healthy growing female rats during acquisition of peak bone mass (PBM)...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - April 24, 2019 Category: Lipidology Source Type: research

Gestational age and maternal status of DHA and other polyunsaturated fatty acids in pregnancy: A systematic review
Discussion: Our findings are consistent with previous observations of increases in lipid mobilisation, coupled with preferential transfer of DHA to the fetus, with advancing gestation. However the number of eligible studies was small and further investigations are required. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA))
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - April 19, 2019 Category: Lipidology Source Type: research

Relationships between docosahexaenoic acid compositions of maternal and umbilical cord erythrocytes in pregnant Japanese women
This study was performed as an adjunct study of the Japan Environment and Children's Study. DHA compositions of maternal erythrocytes at 24-30 weeks of pregnancy and of umbilical cord erythrocytes at delivery were determined in 1368 mother-infant pairs. Median DHA values were 7.41% in the maternal erythrocytes and 6.84% in the umbilical cord erythrocytes, indicating significantly lower levels in the umbilical cord. When DHA composition in maternal erythrocytes was lower than 6.6%, DHA was theoretically higher in umbilical cord erythrocytes than in maternal erythrocytes. Conversely, when DHA composition in maternal erythroc...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - April 13, 2019 Category: Lipidology Source Type: research

The association of maternal polyunsaturated fatty acids during pregnancy with social competence and problem behaviours at 7 years of age: the MEFAB cohort
DiscussionIn this prospective study, increasing maternal AA and decreasing total n-6 were associated with improved social competence and externalizing behaviours, respectively, in 7-year old children. Nonetheless, the clinical significance of the identified associations is modest and further investigations are warranted to clarify the relationship between maternal AA and total n-6 during pregnancy and childhood social and behavioural development. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA))
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - April 13, 2019 Category: Lipidology Source Type: research

Associations of medium and long chain omega-3 polyunsaturated fatty acids with blood pressure in Hispanic and non-Hispanic smokers and nonsmokers
Publication date: Available online 12 April 2019Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Kayla R. Zehr, Allison Segovia, Meera Shah, Mary T. Walsh-Wilcox, Barbara H. Brumbach, Joe R. Anderson, Mary K. WalkerSummaryEpidemiology studies and clinical trials have shown that omega-3 polyunsaturated fatty acids (n-3 PUFAs) are inversely associated with blood pressure. We sought to determine the influence of cigarette smoking and Hispanic ethnicity on this association. Age- and sex-matched smokers and nonsmokers (n=98) 19-50 years old lacking cardiovascular disease were recruited. Systolic and dias...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - April 13, 2019 Category: Lipidology Source Type: research

Editorial Board
Publication date: April 2019Source: Prostaglandins, Leukotrienes and Essential Fatty Acids, Volume 143Author(s): (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA))
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - April 9, 2019 Category: Lipidology Source Type: research

Combining a high DHA multi-nutrient supplement with aerobic exercise: protocol for a randomised controlled study assessing mobility and cognitive function in older women
Publication date: Available online 1 April 2019Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Paul Fairbairn, Fotini Tsofliou, Andrew Johnson, Simon C DyallAbstractThere is a complex interplay between cognition and gait in older people, with declines in gait speed coexisting with, or preceding cognitive decline. Omega-3 fatty acids, B vitamins, vitamin E, phosphatidylserine, and Ginkgo Biloba show promise in preserving mobility and cognitive function in older adults. Exercise benefits mobility and there is evidence suggesting positive interactions between exercise and omega-3 fatty acids on physic...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - April 2, 2019 Category: Lipidology Source Type: research

Fish Oil Protects the Liver from Parenteral Nutrition-induced Injury via GPR120-mediated PPARγ signaling
This study tested the hypothesis that FOLE protects the liver from PN-induced injury through GPR120 signaling. Utilizing a previously described murine model of PN-induced liver injury in which mice develop steatosis in response to an oral parenteral nutrition diet, FOLE was able to preserve normal hepatic architecture in wild type mice, but not in congenic GPR120 knockout (gpr120 -/-) mice. To further characterize the requirement of intact GPR120 for FOLE-mediated hepatic protection, gene expression profiles of key regulators of fat metabolism were measured. PPARγ was identified as a gene that is up-regulated by the PN di...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - March 5, 2019 Category: Lipidology Source Type: research