Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Early α-linolenic acid exposure to embryo reduces pentylenetetrazol-induced seizures in zebrafish larva
Publication date: Available online 1 March 2019Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Savita Kumari, Arindam Ghosh Mazumder, Avantika Bhardwaj, Damanpreet SinghABSTRACTOver the past few years, there has been a tremendous increase in interest of general population toward food-based therapies for management of chronic clinical conditions due to their lesser adverse effects with prolonged use over pharmacotherapies. Foods enriched with omega-3 fatty acids have shown some promising results in case of epilepsy. The present study was envisioned to investigate the effect of early exposure of α-l...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - March 1, 2019 Category: Lipidology Source Type: research

Editorial Board
Publication date: March 2019Source: Prostaglandins, Leukotrienes and Essential Fatty Acids, Volume 142Author(s): (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA))
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - February 15, 2019 Category: Lipidology Source Type: research

Plasma phospholipid fatty acids are associated with altered fibrin clot properties in a population-based setting
Publication date: Available online 7 February 2019Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Z. de Lange, B. Kahler, C.M. Smuts, M. PietersSummaryEvidence regarding the relationship of plasma clot properties with fatty acids is contradictory, owing to different experimental protocols employed. The relationship of fibrinogen and plasma fibrin clot properties with plasma phospholipid fatty acids were cross-sectionally investigated in a population-based setting in 900 individuals. Composite saturated fatty acids (driven by stearic acid) and composite n-3 and n-6 polyunsaturated fatty acids (drive...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - February 8, 2019 Category: Lipidology Source Type: research

Editorial Board
Publication date: February 2019Source: Prostaglandins, Leukotrienes and Essential Fatty Acids, Volume 141Author(s): (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA))
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - January 18, 2019 Category: Lipidology Source Type: research

Relationship between polyunsaturated fatty acid and eating disorders: systematic review and meta-analysis
DiscussionThis meta-analysis indicates abnormal levels of PUFAs in peripheral blood tissues in patients with eating disorders. The relationship between PUFAs and eating disorders should be interpreted cautiously considering the specific lipid metabolism under starvation state. To investigate the role of PUFAs on psychopathological and therapeutic effects in eating disorders, further larger clinical studies are warranted. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA))
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - January 12, 2019 Category: Lipidology Source Type: research

Association of Reported Fish Intake and Supplementation Status with the Omega-3 Index
ConclusionsCurrent AHA recommendations are unlikely to produce a desirable O3I. Consuming at least 3 fish servings per week plus taking an EPA+DHA supplement markedly increases the likelihood of achieving this target level. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA))
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - January 12, 2019 Category: Lipidology Source Type: research

Adipose tissue oxylipin profiles vary by anatomical site and are altered by dietary linoleic acid in rats
Publication date: Available online 27 December 2018Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Lucien GJ Cayer, Anne M Mendonça, Samantha D Pauls, Tanja Winter, Shan Leng, Carla G Taylor, Peter Zahradka, Harold M AukemaAbstractDietary PUFA and their effects on adipose tissue have been well studied, but oxylipins, the oxygenated metabolites of PUFA, have been sparsely studied in adipose tissue. To determine the oxylipin profile and to examine their potential importance in various adipose sites, female and male rats were provided control, high linoleic acid (LA), or high LA and high α-linolenic...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - December 27, 2018 Category: Lipidology Source Type: research

How the plasma lysophospholipid and unesterified fatty acid pools supply the brain with docosahexaenoic acid
Publication date: Available online 25 December 2018Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Richard P Bazinet, Nathalie Bernoud-Hubac, Michel LagardeAbstractThe brain requires a constant supply of docosahexaenoic acid (DHA) from blood to maintain DHA levels within the brain. Several plasma pools have been proposed to supply the brain with DHA, including plasma lipoproteins, lysophosphatidylcholine and unesterified fatty acids. Here we briefly review the evidence for each plasma pool supplying the brain highlighting controversies and remaining questions. We conclude that circulating lysophosp...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - December 25, 2018 Category: Lipidology Source Type: research

Editorial Board
Publication date: January 2019Source: Prostaglandins, Leukotrienes and Essential Fatty Acids, Volume 140Author(s): (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA))
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - December 14, 2018 Category: Lipidology Source Type: research

Characterization of Cysteinyl Leukotriene-Related Receptors and Their Interactions in a Mouse Model of Asthma
Publication date: Available online 12 December 2018Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Hoang Kim Tu Trinh, Dong-Hyeon Suh, Thuy Van Thao Nguyen, Youngwoo Choi, Hae-Sim Park, Yoo Seob ShinAbstractIdentification of the characterization of cysteinyl leukotrienes receptor (CysLTRs) could facilitate our understanding of these receptors’ role in asthma. We aimed to investigate the localization and interactions of CysLTRs using a mouse model of asthma. BALB/c mice were administered ovalbumin (OVA) to induce allergic asthma. Some mice were administered the antagonists of CysLTR1, CysLTR2, and...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - December 13, 2018 Category: Lipidology Source Type: research

Lowering the linoleic acid to alpha-linoleic acid ratio decreases the production of inflammatory mediators by cultured human endothelial cells
Publication date: Available online 12 December 2018Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Christian S. Bork, Ella J. Baker, Søren Lundbye-Christensen, Elizabeth A. Miles, Philip C. CalderAbstractAlpha-linolenic acid (ALA) and linoleic acid (LA) are precursors for longer-chain more unsaturated fatty acids and for lipid signaling molecules that may influence inflammatory processes through a variety of mechanisms. The actions of LA and ALA may be divergent and interdependent. The aim of this study was to investigate the incorporation and metabolism of ALA and LA in cultured in EA.hy926 endot...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - December 12, 2018 Category: Lipidology Source Type: research

Emergence of omega-3 fatty acids in biomedical research
Publication date: Available online 3 December 2018Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Arthur A. Spector, Hee-Yong KimABSTRACTShortly after the discovery that linoleic acid was an essential fatty acid in 1930, α-linolenic acid also was reported to prevent the fatty acid deficiency syndrome in animals. However, several prominent laboratories could not confirm the findings with α-linolenic acid, and as a result there was a loss of interest in omega-3 fatty acids in lipid research. Even the findings that a prostaglandin can be synthesized from eicosapentaenoic acid (EPA) and docosahexaeno...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - December 4, 2018 Category: Lipidology Source Type: research

Combined administration of docosahexaenoic acid and thyroid hormone synergistically enhances rat liver levels of resolvins RvD1 and RvD2
Publication date: Available online 29 November 2018Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Luis A. Videla, Romina Vargas, Rodrigo Valenzuela, Patricio Muñoz, Alicia Corbari, María C. Hernandez-RodasAbstractSupplementation with omega-3 fatty acids or thyroid hormone (T3) exhibit negative effects on inflammatory reactions in experimental animals. The aim of this work was to assess the hypothesis that docosahexaenoic acid (DHA) and T3 co-administration enhances liver resolvin (Rv) levels as inflammation resolution mediators. Combined DHA (daily doses of 300 mg/kg for 3 consecutive days)-T3 (...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - November 29, 2018 Category: Lipidology Source Type: research

The Endocannabinoid System: Overview of an Emerging Multi-faceted Therapeutic Target
Publication date: Available online 29 November 2018Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Dipanjan Chanda, Dietbert Neumann, Jan F.C. GlatzAbstractThe endocannabinoids anandamide (AEA) and 2-arachidonoylglyerol (2-AG) are endogenous lipid mediators that exert protective roles in pathophysiological conditions, including cardiovascular diseases. In this brief review, we provide a conceptual framework linking endocannabinoid signaling to the control of the cellular and molecular hallmarks, and categorize the key components of endocannabinoid signaling that may serve as targets for novel thera...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - November 29, 2018 Category: Lipidology Source Type: research

Vitamin D Deficiency Influences Fatty Acid Metabolism
Publication date: Available online 29 November 2018Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): A. Nandi, N. Wadhwani, S.R. JoshiAbstractReports indicate that maternal vitamin D deficiency may be associated with increased inflammation. Long chain polyunsaturated fatty acids (LCPUFA); omega-3 and omega-6 fatty acids are known to have anti-inflammatory and pro-inflammatory properties respectively. The present study examines the effect of vitamin D deficiency on fatty acid composition and metabolism in a rat model. Female Wistar rats were randomly divided into two groups (n=8/group) as follows; con...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - November 29, 2018 Category: Lipidology Source Type: research