Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Docosahexaenoic acid (DHA): An essential nutrient and a nutraceutical for brain health and diseases
Publication date: Available online 10 March 2017Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Grace Y. Sun, Agnes Simonyi, Kevin L. Fritsche, Dennis Y. Chuang, Mark Hannink, Zezong Gu, C. Michael Greenlief, Jeffrey K. Yao, James C. Lee, David Q. BeversdorfAbstractDocosahexaenoic acid (DHA), a polyunsaturated fatty acid (PUFA) enriched in phospholipids in the brain and retina, is known to play multi-functional roles in brain health and diseases. While arachidonic acid (AA) is released from membrane phospholipids by cytosolic phospholipase A2 (cPLA2), DHA is linked to action of the Ca2+-independent...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - July 10, 2018 Category: Lipidology Source Type: research

Polyphenol supplementation inhibits physiological increase of prostaglandin E2 during reproductive period – A randomized clinical trial
This study aimed to evaluate the effect of polyphenol supplementation in plasma levels of prostaglandin E2 and other markers of inflammation and oxidative stress in women using contraceptives. In this randomized double-blind clinical trial, women aged 25–35 years were selected. Participants received capsules containing polyphenols or placebo, to be consumed for fifteen days. From 40 women randomized, 28 completed the study. Control group showed a significant increase in the levels of PGE2 (p=0.01) while the polyphenols group showed no change in these levels (p=0.79). There was an increase in hs-CRP (p<0.01) and F2-is...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - July 10, 2018 Category: Lipidology Source Type: research

Fatty acid transporting proteins: Roles in brain development, aging, and stroke
Publication date: Available online 21 April 2017Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Wenting Zhang, Ruiying Chen, Tuo Yang, Na Xu, Jun Chen, Yanqin Gao, R. Anne StetlerAbstractPolyunsaturated fatty acids are required for the brain development and significantly impact aging and stroke. Due to the hydrophobicity of fatty acids, fatty acids transportation related proteins that include fatty acid binding proteins (FABPs), long chain acyl-coA synthase (ACS), fatty acid transportation proteins (FATPs), fatty acid translocase (FAT/CD36) and newly reported major facilitator superfamily domain-co...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - July 10, 2018 Category: Lipidology Source Type: research

Role of polyunsaturated fatty acids in human brain structure and function across the lifespan: An update on neuroimaging findings
Publication date: Available online 9 May 2017Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Robert K. McNamara, Ruth H. Asch, Diana M. Lindquist, Robert KrikorianAbstractThere is a substantial body of evidence from animal studies implicating polyunsaturated fatty acids (PUFA) in neuroinflammatory, neurotrophic, and neuroprotective processes in brain. However, direct evidence for a role of PUFA in human brain structure and function has been lacking. Over the last decade there has been a notable increase in neuroimaging studies that have investigated the impact of PUFA intake and/or blood levels (i....
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - July 10, 2018 Category: Lipidology Source Type: research

Methylnicotinate stimulated prostaglandin synthesis in patients with schizophrenia: A preliminary investigation
Publication date: Available online 19 May 2017Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Brian M. RossAbstractSchizophrenia is a serious mental illness of unclear aetiology. The reduced ability of methylnicotinate to induce a topical vasodilatory response in patients with the disorder is well established. Methylnicotinate causes vasodilation via stimulating the release of prostaglandins (including prostaglandin D2) in the skin which in turn leads to relaxation of vascular smooth muscle. To determine whether the abnormality is likely to be due to decreased prostaglandin production, or a decreas...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - July 10, 2018 Category: Lipidology Source Type: research