Fatty acid transporting proteins: Roles in brain development, aging, and stroke

Publication date: Available online 21 April 2017Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Wenting Zhang, Ruiying Chen, Tuo Yang, Na Xu, Jun Chen, Yanqin Gao, R. Anne StetlerAbstractPolyunsaturated fatty acids are required for the brain development and significantly impact aging and stroke. Due to the hydrophobicity of fatty acids, fatty acids transportation related proteins that include fatty acid binding proteins (FABPs), long chain acyl-coA synthase (ACS), fatty acid transportation proteins (FATPs), fatty acid translocase (FAT/CD36) and newly reported major facilitator superfamily domain-containing protein (Mfsd2a) play critical roles in the uptake of various fatty acids, especially polyunsaturated fatty acids. They are not only involved in neurodevelopment, but also have great impact on neurological disease, such as aging related dementia and stroke.
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - Category: Lipidology Source Type: research