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Exploring different photodynamic therapy parameters to optimize elimination of Enterococcus faecalis in planktonic form
Effective elimination of microorganisms in infected root canals represents a constant challenge in clinical practice [1 –3]. In chronic endodontic infections the microorganisms are organized in an extracellular polysaccharide matrix forming bacterial biofilms [1,2]. Unlike planktonic forms, in this structuring the elimination of the infectious process requires high doses of drugs or the microorganisms become refrac tory to conventional treatment protocols [2,3]. Despite technological advances in chemomechanical preparation including new instruments and irrigation devices persistent microorganisms in both biofilm and plan...
Source: Photodiagnosis and Photodynamic Therapy - March 29, 2018 Category: Laser Surgery Authors: Janir Alves Soares, Suelleng Maria Cunha Santos Soares, Rudys Rodolfo de Jesus Tavarez, Claudia de Castro Rizzi, Silvana Cristina Gama Vaz Rodrigues, Etevaldo Matos Maia Filho, Manoel Brito-J únior, Rodrigo Dantas Pereira, Paula Prazeres Magalhães, Luiz Source Type: research

Exploring different photodynamic therapy parameters to optimize elimination of Enterococcus faecalis planktonic forms
Effective elimination of microorganisms in infected root canals represents a constant challenge in clinical practice [1 –3]. In chronic endodontic infections the microorganisms are organized in an extracellular polysaccharide matrix forming bacterial biofilms [1,2]. Unlike planktonic forms, in this structuring the elimination of the infectious process requires high doses of drugs or the microorganisms become refrac tory to conventional treatment protocols [2,3]. Despite technological advances in chemomechanical preparation including new instruments and irrigation devices persistent microorganisms in both biofilm and plan...
Source: Photodiagnosis and Photodynamic Therapy - March 29, 2018 Category: Laser Surgery Authors: Janir Alves Soares, Suelleng Maria Cunha Santos Soares, Rudys Rodolfo de Jesus Tavarez, Claudia de Castro Rizzi, Silvana Cristina Gama Vaz Rodrigues, Etevaldo Matos Maia Filho, Manoel Brito-J únior, Rodrigo Dantas Pereira, Paula Prazeres Magalhães, Luiz Source Type: research

Protoporphyrin IX formation after application of methyl aminolevulinate on the face and scalp with and without prior curettage
Actinic keratosis (AK) is a precursor for cutaneous squamous cell carcinoma [1]. AKs are classified according to their degree of keratinization, but this does not predict the risk of malignant transformation [2,3], and field treatment of all AKs is therefore recommended [4]. (Source: Photodiagnosis and Photodynamic Therapy)
Source: Photodiagnosis and Photodynamic Therapy - March 27, 2018 Category: Laser Surgery Authors: Ida M. Heerfordt, Giedre Bieliauskiene, Hans Christian Wulf Source Type: research

Theranostic-PDT with the antibody anti isoform 4 SOD mitocondrial labeled with PpIX in the lung cancer cell line A-549
Due to its metastatic potential and high mortality rate, the lung cancer is one of the leading causes of death around the world with more than 900,000 cases reported annually [1]. This cancer is generally divided into two classes, namely the small cell lung cancer (SCLC) and the non-small cell lung cancer (NSCLC). NSCLC constitutes approximately 80 % of all lung cancers diagnosed and consists of two major subtypes, adenocarcinoma (ADC) and squamous cell carcinoma (SQC). (Source: Photodiagnosis and Photodynamic Therapy)
Source: Photodiagnosis and Photodynamic Therapy - March 27, 2018 Category: Laser Surgery Authors: Claudia Mart ínez-García, Yolanda Medina-Flores, José Manuel de la Rosa-Vázquez, Eva Elda Soriano-Pérez, Juan Ramón Villalobos-Hernández, Eva Ramón-Gallegos Source Type: research

Protoporphyrin IX formation after application of methyl aminolevulinate on the face and scalp with and without prior curettage
Actinic keratosis (AK) is a precursor for cutaneous squamous cell carcinoma [1]. AKs are classified according to their degree of keratinization, but this does not predict the risk of malignant transformation [2,3], and field treatment of all AKs is therefore recommended [4]. (Source: Photodiagnosis and Photodynamic Therapy)
Source: Photodiagnosis and Photodynamic Therapy - March 27, 2018 Category: Laser Surgery Authors: Ida M. Heerfordt, Giedre Bieliauskiene, Hans Christian Wulf Source Type: research

Theranostic-PDT with the antibody anti isoform 4 SOD mitocondrial labeled with PpIX in the lung cancer cell line A-549
Due to its metastatic potential and high mortality rate, the lung cancer is one of the leading causes of death around the world with more than 900,000 cases reported annually [1]. This cancer is generally divided into two classes, namely the small cell lung cancer (SCLC) and the non-small cell lung cancer (NSCLC). NSCLC constitutes approximately 80 % of all lung cancers diagnosed and consists of two major subtypes, adenocarcinoma (ADC) and squamous cell carcinoma (SQC). (Source: Photodiagnosis and Photodynamic Therapy)
Source: Photodiagnosis and Photodynamic Therapy - March 27, 2018 Category: Laser Surgery Authors: Claudia Mart ínez-García, Yolanda Medina-Flores, José Manuel de la Rosa-Vázquez, Eva Elda Soriano-Pérez, Juan Ramón Villalobos-Hernández, Eva Ramón-Gallegos Source Type: research

A review of nanoparticle photosensitizer drug delivery uptake systems for photodynamic treatment of lung cancer
Lung cancer can be defined as an out-of-control, malignant growth that develops in the lung tissues causing tumourous growths [1 –4]. Lung cancer is the most commonly diagnosed cancer worldwide, with an estimated death rate of 1.4 million cases each year [5]. Moreover, it is expected that the lung cancer mortality rate will increase up to 3 million cases by 2035 [6]. (Source: Photodiagnosis and Photodynamic Therapy)
Source: Photodiagnosis and Photodynamic Therapy - March 26, 2018 Category: Laser Surgery Authors: Mpho Gift Mokwena, Cherie Ann Kruger, Mfouo-Tynga Ivan, Abrahamse Heidi Source Type: research

Titania and silica nanoparticles coupled to Chlorin e6 for anti-cancer photodynamic therapy
Photodynamic therapy (PDT) has emerged as an alternative and promising minimally invasive treatment modality for certain types of cancers. For example, in dermatology, PDT is gradually becoming the reference treatment for actinic keratoses (KA), superficial basal cell carcinomas and Bowen's disease [1]. In ophthalmology, PDT with Visudyne ® has been very popular in the treatment of patients with Age-related macular degeneration [2]. In urology, the French company Steba-Biotech [3] has developed Tookad® as a new PS for the treatment of prostate cancer. (Source: Photodiagnosis and Photodynamic Therapy)
Source: Photodiagnosis and Photodynamic Therapy - March 26, 2018 Category: Laser Surgery Authors: Zahraa Youssef, Val érie Jouan-Hureaux, Ludovic Colombeau, Philippe Arnoux, Albert Moussaron, Francis Baros, Joumana Toufaily, Tayssir Hamieh, Thibault Roques-Carmes, Céline Frochot Source Type: research

A Review of Nanoparticle Photosensitizer Drug Delivery Uptake Systems for Photodynamic Treatment of Lung Cancer
Lung cancer can be defined as an out-of-control, malignant growth that develops in the lung tissues causing tumourous growths [1 –4]. Lung cancer is the most commonly diagnosed cancer worldwide, with an estimated death rate of 1.4 million cases each year [5]. Moreover, it is expected that the lung cancer mortality rate will increase up to 3 million cases by 2035 [6]. (Source: Photodiagnosis and Photodynamic Therapy)
Source: Photodiagnosis and Photodynamic Therapy - March 26, 2018 Category: Laser Surgery Authors: Mokwena Mpho Gift, Kruger Cherie Ann, Mfouo-Tynga Ivan, Abrahamse Heidi Source Type: research

Titania And Silica Nanoparticles Coupled To Chlorin e6 For Anti-Cancer Photodynamic Therapy
Photodynamic therapy (PDT) has emerged as an alternative and a promising minimally invasive treatment modality for certain types of cancers and is becoming adapted in clinics nowadays. For example, in dermatology, PDT is gradually becoming the reference treatment for actinic keratoses (KA), superficial basal cell carcinomas and Bowen's disease [1]. In ophthalmology, PDT with Visudyne ® has been very popular in the treatment of patients with Age-related macular degeneration [2]. In urology, the French company Steba-Biotech [3] has developed Tookad® as a new PS for the treatment of prostate cancer. (Source: Photodiagnosis ...
Source: Photodiagnosis and Photodynamic Therapy - March 26, 2018 Category: Laser Surgery Authors: Zahraa Youssef, Val érie Jouan-Hureaux, Ludovic Colombeau, Philippe Arnoux, Albert Moussaron, Francis Baros, Joumana Toufaily, Tayssir Hamieh, Thibault Roques-Carmes, Céline Frochot Tags: Original Research Source Type: research

Diagnostic accuracy of multiplex real-time PCR approaches compared with cultivation -based detection methods: Monitoring the endopathogenic microbiota pre and post photo-activated disinfection
Endodontic infection also known as polymicrobial infection of the dental root canal system forms the primary etiological agent of the periradicular inflammatory diseases [1]. Calcium hydroxide (Ca[OH]2), chlorhexidine (CHX), and sodium hypochlorite (NaOCl) are widely used as the intracanal medication in clinical practice [2]. The endopathogenic microbiota cannot be completely eliminated from the root canals using these chemo-mechanical antiseptic agents, and may also achieve resistance against the disinfecting agents and endodontic medicaments [3]. (Source: Photodiagnosis and Photodynamic Therapy)
Source: Photodiagnosis and Photodynamic Therapy - March 22, 2018 Category: Laser Surgery Authors: Maryam Pourhajibagher, Abbas Bahador Source Type: research

Diagnostic accuracy of multiplex real-time PCR approaches in compared with cultivation -based detection methods: Monitoring the endopathogenic microbiota pre and post photo-activated disinfection
Endodontic infection also known as polymicrobial infection of the dental root canal system forms the primary etiological agent of the periradicular inflammatory diseases [1]. Calcium hydroxide (Ca[OH]2), chlorhexidine (CHX), and sodium hypochlorite (NaOCl) are widely used as the intracanal medication in clinical practice [2]. The endopathogenic microbiota cannot be completely eliminated from the root canals using these chemo-mechanical antiseptic agents, and may also achieve resistance against the disinfecting agents and endodontic medicaments [3]. (Source: Photodiagnosis and Photodynamic Therapy)
Source: Photodiagnosis and Photodynamic Therapy - March 22, 2018 Category: Laser Surgery Authors: Maryam Pourhajibagher, Abbas Bahador Source Type: research

Chlorin Nanoparticles for Tissue Diagnostics and Photodynamic Therapy
The Chlorin compound Temoporfin, mTHPC (meta-tetrahydroxyphenylchlorin), is a potent photosensitizer used in the product Foscan ® (Biolitec, Jena) and also in the liposomal formulation Foslip. Foscan® as molecular solution is approved in Europe for photodynamic therapy of head and neck cancer. However, instead of using formulations to make mTHPC soluble for systemic applications, the idea arose to study nanoparticles produ ced from the insoluble raw material mTHPC. It is evident that mTHPC-derived nanoparticles are not fluorescent because of the crystalline structure of such flat molecules [1]. (Source: Photodiagnosis an...
Source: Photodiagnosis and Photodynamic Therapy - March 19, 2018 Category: Laser Surgery Authors: Claudia Scalfi-Happ, Zhenxin Zhu, Susanna Graefe, Arno Wiehe, Anastasia Ryabova, Victor Loschenov, Rainer Wittig, Rudolf W. Steiner Source Type: research