Prototheca wickerhamii olecranon bursitis successfully treated with adjunctive systemic itraconazole
No abstract available (Source: Pathology)
Source: Pathology - May 8, 2015 Category: Pathology Tags: Correspondence Source Type: research
Antimicrobial susceptibility reporting and treatment selection for AmpC-producing Enterobacteriaceae: what do microbiologists and infectious disease practitioners actually practice?
No abstract available (Source: Pathology)
Source: Pathology - May 8, 2015 Category: Pathology Tags: Correspondence Source Type: research
A rare case of primary retroperitoneal mucinous neoplasm in a male patient
No abstract available (Source: Pathology)
Source: Pathology - May 8, 2015 Category: Pathology Tags: Correspondence Source Type: research
Tophaceous gout in the pelvis
No abstract available (Source: Pathology)
Source: Pathology - May 8, 2015 Category: Pathology Tags: Correspondence Source Type: research
Malignant inflammatory myofibroblastic tumour of the uterus
No abstract available (Source: Pathology)
Source: Pathology - May 8, 2015 Category: Pathology Tags: Correspondence Source Type: research
Misdiagnosed MYH9 related inherited macrothrombocytopenia with an inadvertent splenectomy
No abstract available (Source: Pathology)
Source: Pathology - May 8, 2015 Category: Pathology Tags: Correspondence Source Type: research
Monoclonal precursor T-cell infiltrate in recurrent thymoma: a case report
No abstract available (Source: Pathology)
Source: Pathology - May 8, 2015 Category: Pathology Tags: Correspondence Source Type: research
Metachronous classical Hodgkin's lymphoma and ALK-positive anaplastic large cell lymphoma
No abstract available (Source: Pathology)
Source: Pathology - May 8, 2015 Category: Pathology Tags: Correspondence Source Type: research
Epidemiology of invasive group A Streptococcus infections in Sydney, Australia
Summary: There is concern of global resurgence of invasive group A Streptococcus (iGAS) infections. We compared the clinical and molecular epidemiology of patients admitted with iGAS over two time periods, 2008 and 2010, in Western Sydney, Australia. The annual incidence was 19 cases per 100,000 admissions in 2008, compared to 33 per 100,000 in 2010. An increasing proportion of patients died (0% versus 13%), had an APACHE II score ≥30 (0% versus 19%), and had no known risk-factors (12% versus 25%). A potential skin source was identified as a trigger in fewer cases in 2010 (36% versus 11%). In total, there were 27 differe...
Source: Pathology - May 8, 2015 Category: Pathology Tags: Microbiology Source Type: research
The effect of dabigatran on haemostasis tests: a comprehensive assessment using in vitro and ex vivo samples
Summary: The new direct oral anticoagulants (DOACS) dabigatran, rivaroxaban, apixaban and edoxaban provide alternatives to warfarin for treatment and prevention of atrial fibrillation and venous thromboembolic disease in various settings. These have been developed as not requiring laboratory monitoring; however, under certain clinical situations, including recent haemorrhage/thrombosis, emergency surgical procedures, testing may be indicated.
The aim of this study was to assess findings of haemostasis laboratory tests for one of the DOACs, dabigatran (Pradaxa), tested across a wide range of laboratory assays.
Laboratories ...
Source: Pathology - May 8, 2015 Category: Pathology Tags: Haematology Source Type: research
BRAF mutation detection in hairy cell leukaemia from archival haematolymphoid specimens
Summary: Hairy cell leukaemia (HCL) is a rare, indolent chronic B-cell leukaemia accounting for approximately 2% of all adult leukaemias. The recent association of the BRAF p.Val600Glu (V600E) mutation in HCL makes it a valuable molecular diagnostic marker. We compared the ability of Sanger sequencing, fluorescent single-strand conformational polymorphism (F-SSCP) and high resolution melting (HRM) analysis to detect BRAF mutations in 20 cases of HCL consisting of four archival Romanowsky stained air-dried peripheral blood and bone marrow aspirate smears, 12 mercury fixed decalcified bone marrow trephine biopsies, three for...
Source: Pathology - May 8, 2015 Category: Pathology Tags: Haematology Source Type: research
Increased apolipoprotein A5 expression in human and rat non-alcoholic fatty livers
Summary: Apolipoprotein A5 (apoA5) is a potent regulator of triglyceride (TG) metabolism and therefore may contribute to the pathogenesis of non-alcoholic fatty liver disease (NAFLD), a disease characterised by excessive TG-rich lipid droplets in hepatocytes. To test this hypothesis, we examined the mRNA expression of apoA5 in paediatric NAFLD livers in comparison to healthy controls. According to microarray and quantitative real-time PCR, human NAFLD livers exhibited elevated apoA5 expression compared to healthy controls. The apoA5 expression levels were positively correlated with hepatic TG storage and a marker for lipid...
Source: Pathology - May 8, 2015 Category: Pathology Tags: Chemical Pathology Source Type: research
Is vitamin D testing at a tertiary referral hospital consistent with guideline recommendations?
Summary: To determine if 25 hydroxyvitamin D (25OHD) testing at our tertiary referral hospital is consistent with guideline recommendations concerning the clinical indications for testing, the timing of repeat testing and utilisation of the test result, we conducted a retrospective audit of electronic laboratory and patient case records. We included adult inpatients and outpatients who had serum 25OHD measured during a randomly selected one-week audit period and who had patient case records available for detailed review. The audit sample comprised 184 serum 25OHD measurements (134 initial and 50 repeat tests). There were 8...
Source: Pathology - May 8, 2015 Category: Pathology Tags: Chemical Pathology Source Type: research
Validation of mitosis counting by automated phosphohistone H3 (PHH3) digital image analysis in a breast carcinoma tissue microarray
Summary: Mitosis counting in H&E stained sections is the most informative constituent of the Nottingham histological grade in breast carcinoma prognosis. Phosphohistone H3 (PHH3) immunohistochemistry (IHC) is a highly specific marker of mitoses, with practical application in identifying mitoses in poorly fixed or distorted tissue and is of prognostic significance in breast carcinoma. Our aim was to assess methods of PHH3 IHC mitosis counting in a tissue microarray (TMA) of 2 mm cores from 36 resected breast carcinomas. Mitoses in H&E and PHH3 stained slides were manually scored by pathologist consensus and expressed as c...
Source: Pathology - May 8, 2015 Category: Pathology Tags: Anatomical Pathology Source Type: research
Correlation between MET protein expression and MET gene copy number in a Caucasian cohort of non-small cell lung cancers according to the new IASLC/ATS/ERS classification
Summary: MET pathway is a promising target in non-small cell lung cancers (NSCLC) requiring companion tests. The aim of this study was to compare MET expression/gene copy number in a Caucasian population of NSCLC patients.
We analysed 201 NSCLC, with 141 adenocarcinomas classified according to 2011 IASLC recommendations, for MET expression by immunohistochemistry (IHC) and gene copy number (GCN) by silver in situ hybridisation (SISH) on tissue microarrays. Mutations in EGFR, KRAS, BRAF, HER2, PIK3CA genes and ALK rearrangements were determined.
MET overexpression was observed in 44% and a high MET GCN (≥5 copies) in 14%....
Source: Pathology - May 8, 2015 Category: Pathology Tags: Anatomical Pathology Source Type: research
