Lipid storing pyloric metaplasia of the gall bladder
No abstract available (Source: Pathology)
Source: Pathology - November 17, 2014 Category: Pathology Tags: Correspondence Source Type: research
Thyroid-like follicular renal cell carcinoma: an emerging morphological variant
No abstract available (Source: Pathology)
Source: Pathology - November 17, 2014 Category: Pathology Tags: Correspondence Source Type: research
Adenocarcinoma arising within ectopic prostatic tissue in the urinary bladder
No abstract available (Source: Pathology)
Source: Pathology - November 17, 2014 Category: Pathology Tags: Correspondence Source Type: research
Renal cell carcinoma with rhabdoid features and loss of INI1 expression in an individual without sickle cell trait
No abstract available (Source: Pathology)
Source: Pathology - November 17, 2014 Category: Pathology Tags: Correspondence Source Type: research
An experience with dracunculiasis in Melbourne, Australia
No abstract available (Source: Pathology)
Source: Pathology - November 17, 2014 Category: Pathology Tags: Correspondence Source Type: research
Multidrug resistant, blaVEB positive Pseudomonas aeruginosa causing high mortality among haematology patients
No abstract available (Source: Pathology)
Source: Pathology - November 17, 2014 Category: Pathology Tags: Correspondence Source Type: research
Urgent cerebrospinal fluid analysis: is it necessary?
No abstract available (Source: Pathology)
Source: Pathology - November 17, 2014 Category: Pathology Tags: Correspondence Source Type: research
Human T-lymphotropic virus-1 serology in the Northern Territory: 2008–2011
SummaryA retrospective observational study of human T-lymphotropic virus-1 (HTLV-1) serology requests made to the Northern Territory Government Pathology Service (NTGPS) between 2008 and 2011, was undertaken to review aspects of HTLV-1 sero-epidemiology and performance of the assays. A total of 5686 HTLV-1 serology requests, representing 3555 individual patients, were received during the study period; 368 HTLV-1 confirmed positive serology results were identified from the 3555 individual patients included in the sample. There was a distinct difference in the performance of the two antibody assays in use during this period,...
Source: Pathology - November 17, 2014 Category: Pathology Tags: Virology Source Type: research
RT-PCR testing of allograft musculoskeletal tissue: is it time for culture-based methods to move over?
This study evaluated the recovery of low numbers of challenge organisms from inoculated swab and musculoskeletal biopsy samples using solid agar culture, cooked meat medium, blood culture bottles and a RT-PCR assay. It was found that broth culture methods were the most sensitive with RT-PCR unable to detect low numbers of bacteria from these samples. Investigation of other non-culture methods may be worthwhile. (Source: Pathology)
Source: Pathology - November 17, 2014 Category: Pathology Tags: Microbiology Source Type: research
Clinical impact of reducing routine blood culture incubation time from 7 to 5 days
SummaryThe aim of this study was to determine the clinical impact of reducing the blood culture incubation protocol from 7 to 5 days.A laboratory data extraction identified positive blood cultures occurring after 5 or more days of incubation at Canberra Hospital, Australia between 1 January 2001 and 31 August 2011. Isolates were identified as clinically significant using a pre-existing prospective bacteraemia database. Medical records review determined whether the positive result affected clinical management.Positive blood cultures after 5 or more days of incubation accounted for 2.65% (423/15979) of all positive blood cul...
Source: Pathology - November 17, 2014 Category: Pathology Tags: Microbiology Source Type: research
Hereditary protein C deficiency caused by compound heterozygous mutants in two independent Chinese families
We report two compound heterozygous mutants that caused severe type I protein C (PC) deficiency in two independent Chinese families.PC antigen was determined by enzyme-linked immunosorbent assay (ELISA), and PC activity was measured by chromogenic assay. Genetic mutations were screened with polymerase chain reaction (PCR) followed by direct sequencing. PC mutants were transiently expressed in COS-7 cells for the evaluation of PC secretory activity and function. The subcellular location was visualised by immunofluorescence assay. The structural analysis of mutation was performed as well.Compound heterozygous mutations of Ar...
Source: Pathology - November 17, 2014 Category: Pathology Tags: Haematology Source Type: research
Expression of multidrug resistance 1 gene in association with CXCL12 in chronic myelogenous leukaemia
We examined the interaction of recently defined bone marrow microenvironment factors CXCL12 and ATP-binding cassette (ABC) transporters in the bone marrow of CML patients in the chronic phase and blast crisis.Expression levels of mRNA extracted from frozen specimens of CML patients were measured by real-time polymerase chain reaction. The expression of the ABC transporters MDR1, ABCC1, ABCG2, and CXCL12 was significantly higher in the bone marrow samples of CML blast crisis than in those of CML chronic phase. Immunohistochemical staining for CXCL12 revealed that the proportion of CXCL12 positive reticular cell areas correl...
Source: Pathology - November 17, 2014 Category: Pathology Tags: Haematology Source Type: research
High APRIL expression correlates with unfavourable survival of gastrointestinal stromal tumour
SummaryA proliferation inducing ligand (APRIL) is a member of the tumour necrosis factor superfamily. High APRIL expression has been found to correlate with tumour development, suggesting that APRIL participates in oncogenesis. However, little is known about APRIL expression in gastrointestinal stromal tumours (GISTs) or the relationship between APRIL expression and the clinical characteristics of GIST. Therefore, we assessed the expression of APRIL immunohistochemically using a tissue microarray from 178 patients with GIST and evaluated the relationship between APRIL expression and patient prognosis. Strong APRIL expressi...
Source: Pathology - November 17, 2014 Category: Pathology Tags: Anatomical Pathology Source Type: research
Mycosis fungoides with large cell transformation: clinicopathological features and prognostic factors
SummaryLarge cell transformation of mycosis fungoides (MF-LCT) occurs in 20–50% of advanced MF, and is generally associated with poor prognosis, although some patients have indolent disease. We sought to identify clinicopathological prognostic factors in a large number of patients with MF-LCT.We identified patients with MF-LCT treated between 1991 and 2012 at a referral centre for cutaneous lymphoma. Clinical and pathological records, and histopathological slides were reviewed. Associations of clinicopathological variables with disease-specific survival were analysed.In 51 patients with MF-LCT, factors significantly asso...
Source: Pathology - November 17, 2014 Category: Pathology Tags: Anatomical Pathology Source Type: research
Diffuse mesothelioma of the peritoneum: correlation between histological and clinical parameters and survival in 73 patients
In this study, survival data were obtained retrospectively from 73 patients treated with intended cytoreductive surgery for DPM, with a mean follow-up of 42 months. Mesotheliomas were classified as well differentiated papillary (WDPM, n = 2), multicystic (MCM, n = 4), and epithelioid mesotheliomas were subclassified as tubulopapillary (TPM, n = 27), solid/deciduoid (S/DM, n = 34), and or biphasic mesothelioma (BPM, n = 6). Invasion was characterised as absent (grade 0), into stroma (grade 1), into fat (grade 2), and into adjacent structures (grade 3). Peritoneal cancer index (PCI) and completeness of cy...
Source: Pathology - November 17, 2014 Category: Pathology Tags: Anatomical Pathology Source Type: research
