Frameshift mutations of TAF1C gene, a core component for transcription by RNA polymerase I, and its regional heterogeneity in gastric and colorectal cancers
In this study, we found TAF1C frameshift mutations (8.8% of GC and 10.1% of CRC with MSI-H), which were not found in stable MSI/low MSI (MSS/MSI-L) (0/90). In addition, we analysed intratumoural heterogeneity (ITH) of TAF1C frameshift mutations in 16 CRC and found that three CRC (18.8%) harboured regional ITH of the TAF1C frameshift mutations.Our results indicate that TAF1C gene harboured not only somatic frameshift mutations but also the mutational ITH, which together might play a role in tumourigenesis of GC and CRC. Our data also suggest that multi-regional mutation analysis is needed for a better evaluation of the muta...
Source: Pathology - January 8, 2015 Category: Pathology Tags: Anatomical Pathology Source Type: research
Hepatitis E virus: do locally acquired infections in Australia necessitate laboratory testing in acute hepatitis patients with no overseas travel history?
SummaryHepatitis E virus (HEV) is emerging as a global public health threat. Water-borne HEV outbreaks are common in developing countries and are associated with genotypes 1 and 2. In industrialised countries, sporadic cases of zoonotic transmission associated with genotypes 3 and 4 are increasingly being reported. Transfusion- and transplantation-transmitted HEV have been documented, although ingestion of contaminated food is thought to be the major transmission route. Severe disease is possible and chronic hepatitis infection occurs in solid-organ-transplant recipients and in patients with immunosuppressive disorders. In...
Source: Pathology - January 8, 2015 Category: Pathology Tags: Review Source Type: research
Evaluation of HemoCue white blood cell differential counter at a remote health centre in Australia's Northern Territory
No abstract available (Source: Pathology)
Source: Pathology - December 16, 2014 Category: Pathology Tags: Correspondence Source Type: research
Direct identification of bacteria from positive BD-Bactec blood culture bottles on the Vitek MS
No abstract available (Source: Pathology)
Source: Pathology - December 16, 2014 Category: Pathology Tags: Correspondence Source Type: research
Outbreak of locally acquired azithromycin-resistant Shigella flexneri infection in men who have sex with men
No abstract available (Source: Pathology)
Source: Pathology - December 16, 2014 Category: Pathology Tags: Correspondence Source Type: research
A case of ALK negative anaplastic large cell lymphoma with leukaemic manifestation, transformed from CD4 positive T-cell large granular lymphocytic leukaemia
No abstract available (Source: Pathology)
Source: Pathology - December 16, 2014 Category: Pathology Tags: Correspondence Source Type: research
Primary pancreatic ALK negative anaplastic large cell lymphoma
No abstract available (Source: Pathology)
Source: Pathology - December 16, 2014 Category: Pathology Tags: Correspondence Source Type: research
Plasmacytoma with crystal-storing histiocytosis exhibiting FGFR3 and IgH translocation
No abstract available (Source: Pathology)
Source: Pathology - December 16, 2014 Category: Pathology Tags: Correspondence Source Type: research
Combined haemosiderin and melanin pigmentation of prominent submucosal plexus ganglia and nerves within a pedunculated sigmoid tubular adenoma
No abstract available (Source: Pathology)
Source: Pathology - December 16, 2014 Category: Pathology Tags: Correspondence Source Type: research
Cystic alveolar adenoma: an unusual clinical presentation of a rare lung neoplasm
No abstract available (Source: Pathology)
Source: Pathology - December 16, 2014 Category: Pathology Tags: Correspondence Source Type: research
Osteosarcoma arising from metastatic low grade endometrial stromal sarcoma
No abstract available (Source: Pathology)
Source: Pathology - December 16, 2014 Category: Pathology Tags: Correspondence Source Type: research
Malignant extraneural soft tissue perineurioma with striking microvascular proliferation
No abstract available (Source: Pathology)
Source: Pathology - December 16, 2014 Category: Pathology Tags: Correspondence Source Type: research
The utility of serial blood film testing for the diagnosis of malaria
SummaryCurrent guidelines on the diagnosis and exclusion of malaria stipulate that if there is an initial negative result on blood film, multiple blood film preparations should be taken to sufficiently exclude malaria.We looked at a state-wide database of blood results retrospectively for a period of 14 years to identify subjects who had been tested for malaria.Most (93%) of patients were diagnosed on the first blood smear. Almost 7% of patients had an initial negative blood film result but subsequently went on to have a positive result. The majority of patients diagnosed with malaria on the first blood film had Plasmodium...
Source: Pathology - December 16, 2014 Category: Pathology Tags: Microbiology Source Type: research
Diagnostic utility of unidentified precipitin lines (UPLs) in immune precipitation assays
SummaryUnidentified precipitin lines (UPLs) are lines in immune precipitin assays which do not characterise with known extractable nuclear antigen (ENA) antibodies. Currently, the clinical significance of UPLs is uncertain.The aim of this study was to determine the clinical and laboratory correlates of UPLs detected over a 3 year period in a regional immunopathology laboratory.A total of 144 patients with UPLs on ENA testing were retrospectively analysed.ENA by counterimmunoelectrophoresis (CIE) was performed on 11,869 patient samples with further characterisation being performed for 1437 positive results. Ten percent of t...
Source: Pathology - December 16, 2014 Category: Pathology Tags: Immunopathology Source Type: research
Comparative study of five serological assays for the diagnosis of paraneoplastic pemphigus
In this study IIF using either rat or monkey bladder substrates performed strongly, whilst the envoplakin ELISA seemed to lack sensitivity, and the CBA and IIF on rat cardiac substrate were inferior. Our findings suggest that traditional IIF-based assays remain the preferred approach in the serological diagnosis of PNP. (Source: Pathology)
Source: Pathology - December 16, 2014 Category: Pathology Tags: Immunopathology Source Type: research
