Combined serous carcinoma and neuroendocrine carcinoma of the fallopian tube
No abstract available (Source: Pathology)
Source: Pathology - November 19, 2015 Category: Pathology Tags: Correspondence Source Type: research
Laminated saccules: a residuum of an ovarian mature cystic teratoma
No abstract available (Source: Pathology)
Source: Pathology - November 19, 2015 Category: Pathology Tags: Correspondence Source Type: research
BAP1 deficient malignant melanoma arising from the intradermal component of a congenital melanocytic naevus
No abstract available (Source: Pathology)
Source: Pathology - November 19, 2015 Category: Pathology Tags: Correspondence Source Type: research
Nephrotic syndrome in a man with Carney–Stratakis syndrome
No abstract available (Source: Pathology)
Source: Pathology - November 19, 2015 Category: Pathology Tags: Correspondence Source Type: research
B3 thymoma arising within thymolipoma
No abstract available (Source: Pathology)
Source: Pathology - November 19, 2015 Category: Pathology Tags: Correspondence Source Type: research
Giant cell tumour of the gallbladder can mimic undifferentiated/anaplastic carcinoma clinically and pathologically
No abstract available (Source: Pathology)
Source: Pathology - November 19, 2015 Category: Pathology Tags: Correspondence Source Type: research
A rare perivascular epithelioid cell tumour (PEComa) of the duodenum misdiagnosed by endoscopic needle aspiration biopsy
No abstract available (Source: Pathology)
Source: Pathology - November 19, 2015 Category: Pathology Tags: Correspondence Source Type: research
Giant inflammatory polyposis with Crohn disease-like colitis
No abstract available (Source: Pathology)
Source: Pathology - November 19, 2015 Category: Pathology Tags: Correspondence Source Type: research
Tumour procurement, DNA extraction, coverage analysis and optimisation of mutation-detection algorithms for human melanoma genomes
This study was designed to test sample preparation, sequencing specifications and bioinformatic algorithms for their effect on accuracy and cost-efficiency in a large WGS analysis of human melanoma samples.
WGS was performed on melanoma cell lines (n = 15) and melanoma fresh frozen tumours (n = 222). The appropriate level of coverage and the optimal mutation detection algorithm for the project pipeline were determined.
An incremental increase in sequencing coverage from 36X to 132X in melanoma tissue samples and 30X to 103X for cell lines only resulted in a small increase (1–2%) in the number of mutations detecte...
Source: Pathology - November 19, 2015 Category: Pathology Tags: Molecular Pathology Source Type: research
Antibiotic susceptibility of diverse Mycobacterium abscessus complex strains in New South Wales, Australia
This study was performed to examine the subspecies and antibiotic susceptibility of M. abscessus complex isolates collected during 2013 at the statewide New South Wales Mycobacterium Reference Laboratory (NSW MRL), Australia. Mycobacterium abscessus subsp. abscessus accounted for more than half of all M. abscessus isolates (n = 24, 57.1%), and M. abscessus subsp. massiliense comprised the remainder of the isolates (n = 18, 42.9%). There were no M. abscessus subsp. bolletii isolates. The prevalence of antibiotic resistance to all antibiotics, apart from amikacin was high, with 26.3% of isolates being reliably suscep...
Source: Pathology - November 19, 2015 Category: Pathology Tags: Microbiology Source Type: research
Reassessment of H&E stained clot specimens and immunohistochemistry of phosphorylated Stat5 for histological diagnosis of MDS/MPN
Summary: Few studies have comprehensively analysed histopathological findings of bone marrow clots for diagnosis of haematopoietic cell dysplasia. In particular, a limited number of studies have assessed the use of haematoxylin and eosin (H&E) staining, which is generally considered less informative than May-Giemsa staining. In the current study, the utility of bone marrow clot specimens for diagnosis was examined using H&E staining and immunohistochemistry. Patients with myelodysplastic syndromes (MDS) and myelodysplastic/myeloproliferative neoplasm (MDS/MPN), including chronic myelomonocytic leukaemia (CMML), atypical ch...
Source: Pathology - November 19, 2015 Category: Pathology Tags: Haematology/Anatomical Pathology Source Type: research
Epithelioid rhabdomyosarcoma: a clinicopathological study of seven additional cases supporting a distinctive variant with aggressive biological behaviour
This study further demonstrates that epithelioid RMS represents a distinct variant of RMS with an aggressive behaviour. It may be misdiagnosed as poorly differentiated neuroendocrine carcinoma due to co-expression of epithelial and neuroendocrine markers. (Source: Pathology)
Source: Pathology - November 19, 2015 Category: Pathology Tags: Anatomical Pathology Source Type: research
Mammary analogue secretory carcinoma: an evaluation of its clinicopathological and genetic characteristics
Summary: Mammary analogue secretory carcinoma (MASC) is a recently described salivary gland malignancy. We evaluate the clinicopathological characteristics and long-term clinical behaviour of MASCs. A total of 190 primary salivary gland malignancies at a single institution were reviewed along with relevant immunohistochemical and fluorescent in situ hybridisation (FISH) studies to identify MASCs. Nine MASCs were identified predominantly in the parotid with an equal incidence in men and women and mean age of 36 years. The tumour size ranged from 14 to 50 mm (mean 22 mm). MASCs were composed of monotonous cells with vacu...
Source: Pathology - November 19, 2015 Category: Pathology Tags: Anatomical Pathology Source Type: research
Foamy gland changes in gastric-type endocervical neoplasia
This report expands the morphological spectrum exhibited by gastric-type endocervical lesions and the range of anatomical sites in which neoplasms with FG features may be encountered. (Source: Pathology)
Source: Pathology - November 19, 2015 Category: Pathology Tags: Anatomical Pathology Source Type: research
Clinicopathological characterisation of duodenal adenocarcinoma with high CD44 variant 9 expression
Summary: CD44 has been identified as a cancer stem cell (CSC) biomarker in various malignancies. The aim of this study was to elucidate the clinicopathological features of CD44v9 positive cells in duodenal adenocarcinoma (DA).
Twenty-nine DA patients were selected from medical archives at our hospital. CD44v9 expression was analysed together with that of MUC2, MUC5AC, and MUC6 by immunohistochemistry. High levels of CD44v9 expression weakly correlated with inflammatory cell infiltration (r = 0.431, p = 0.020) and MUC6 expression (r = 0.425, p = 0.022). Furthermore, double immunofluorescence staining of CD44...
Source: Pathology - November 19, 2015 Category: Pathology Tags: Anatomical Pathology Source Type: research
