The C ‐terminal region of the major outer sheath protein of Treponema denticola inhibits neutrophil chemotaxis
In this study, we investigated the inhibitory effect of truncated Msp regions on neutrophil chemotaxis and associated signaling pathways. Murine neutrophils were treated with recombinant protein truncations followed by assessment of chemotaxis and associated signal pathway activation. Chemotaxis assays indicate sequences within the C‐terminal region; particularly the first 130 amino acids, have the strongest inhibitory effect on neutrophil chemotaxis. Neutrophils incubated with the C‐terminal region protein also demonstrated the greatest inhibition of Rac1 activation, increased phosphoinositide phosphatase activity, an...
Source: Oral Microbiology and Immunology - April 18, 2017 Category: Microbiology Authors: M.M. Jones, S.T. Vanyo, M.B. Visser Tags: ORIGINAL ARTICLE Source Type: research
The two ‐component system VicRK regulates functions associated with Streptococcus mutans resistance to complement immunity
This article is protected by copyright. All rights reserved. (Source: Oral Microbiology and Immunology)
Source: Oral Microbiology and Immunology - April 5, 2017 Category: Microbiology Authors: L ívia A. Alves, Erika N. Harth‐Chu, Thaís H. Palma, Rafael N. Stipp, Flávia S. Mariano, José F. Höfling, Jacqueline Abranches, Renata O. Mattos‐Graner Tags: Original Article Source Type: research
Behavior of two Tannerella forsythia strains and cell surface mutants in multispecies oral biofilms
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Source: Oral Microbiology and Immunology - April 5, 2017 Category: Microbiology Authors: Susanne Bloch, Thomas Thurnheer, Yukitaka Murakami, Georgios N. Belibasakis, Christina Sch äffer Tags: Original Article Source Type: research
Survival of an Aggregatibacter actinomycetemcomitans quorum sensing luxS mutant in the mouths of Rhesus monkeys: Insights into Ecological Adaptation
This article is protected by copyright. All rights reserved. (Source: Oral Microbiology and Immunology)
Source: Oral Microbiology and Immunology - April 1, 2017 Category: Microbiology Authors: Senthil Kumar Velusamy, Vandana Sampathkumar, Dipti Godboley, Daniel H. Fine Tags: Original Article Source Type: research
Interference of a speB 5 ′ UTR partial deletion with mRNA degradation in Streptococcus pyogenes
This article is protected by copyright. All rights reserved. (Source: Oral Microbiology and Immunology)
Source: Oral Microbiology and Immunology - March 31, 2017 Category: Microbiology Authors: Zhiyun Chen, Lauren Mashburn ‐Warren, Justin Merritt, Michael J. Federle, Jens Kreth Tags: Original Article Source Type: research
Tribute
(Source: Oral Microbiology and Immunology)
Source: Oral Microbiology and Immunology - March 19, 2017 Category: Microbiology Authors: J. London, D. Lunsford, R.J. Palmer Tags: Tribute Source Type: research
The C ‐ terminal region of the Major Outer Sheath Protein (Msp) of Treponema denticola inhibits neutrophil chemotaxis
This article is protected by copyright. All rights reserved. (Source: Oral Microbiology and Immunology)
Source: Oral Microbiology and Immunology - March 13, 2017 Category: Microbiology Authors: Megan M. Jones, Stephen T. Vanyo, Michelle B. Visser Tags: Original Article Source Type: research
Streptococcus mutans SpaP binds to RadD of Fusobacterium nucleatum ssp. polymorphum
In conclusion, we describe an additional role for SpaP as adhesin in interspecies adherence with RadD‐SpaP as the interacting adhesin pair for binding between S. mutans and F. nucleatum ssp. polymorphum. Furthermore, S. mutans attachment to oral fusobacteria appears to involve species‐ and subspecies‐dependent adhesin interactions. (Source: Oral Microbiology and Immunology)
Source: Oral Microbiology and Immunology - February 12, 2017 Category: Microbiology Authors: Lihong Guo, Bhumika Shokeen, Xuesong He, Wenyuan Shi, Renate Lux Tags: ORIGINAL ARTICLE Source Type: research
Hemin Binding by Porphyromonas gingivalis strains is dependent on the presence of A ‐LPS
This article is protected by copyright. All rights reserved. (Source: Oral Microbiology and Immunology)
Source: Oral Microbiology and Immunology - January 21, 2017 Category: Microbiology Authors: Minnie Rangarajan, Joseph Aduse ‐Opoku, Nikolay A. Paramonov, Ahmed Hashim, Michael A. Curtis Tags: Original Article Source Type: research
Streptococcus mutans SpaP Binds to RadD of Fusobacterium nucleatum ssp polymorphum
In conclusion, we describe an additional role for SpaP as adhesin in interspecies adherence with RadD‐SpaP as the interacting adhesin pair for binding between S. mutans and F. nucleatum ssp. polymorphum. Furthermore, S. mutans attachment to oral fusobacteria appears to involve species‐ and subspecies‐dependent adhesin interactions.
This article is protected by copyright. All rights reserved. (Source: Oral Microbiology and Immunology)
Source: Oral Microbiology and Immunology - November 30, 2016 Category: Microbiology Authors: Lihong Guo, Bhumika Shokeen, Xuesong He, Wenyuan Shi, Renate Lux Tags: Original Article Source Type: research
In vitro characterization of biofilms formed by Kingella kingae
This article is protected by copyright. All rights reserved. (Source: Oral Microbiology and Immunology)
Source: Oral Microbiology and Immunology - September 30, 2016 Category: Microbiology Authors: Jeffrey B. Kaplan, Vandana Sampathkumar, Meriem Bendaoud, Alexander K. Giannakakis, Edward T. Lally, Nataliya V. Balashova Tags: Original Article Source Type: research
Structural and functional analysis of de ‐N‐acetylase PgaB from periodontopathogen Aggregatibacter actinomycetemcomitans
This article is protected by copyright. All rights reserved. (Source: Oral Microbiology and Immunology)
Source: Oral Microbiology and Immunology - September 30, 2016 Category: Microbiology Authors: Chaitra Parthiban, Dhanasekaran Varudharasu, Mayilvahanan Shanmugam, Prerna Gopal, Chandran Ragunath, Leonard Thomas, Mark Nitz, Narayanan Ramasubbu Tags: Original Article Source Type: research
Structure –function aspects of the Porphyromonas gingivalis tyrosine kinase Ptk1
Summary
The development of synergistically pathogenic communities of Porphyromonas gingivalis and Streptococcus gordonii is controlled by a tyrosine‐phosphorylation‐dependent signaling pathway in P. gingivalis. The Ptk1 bacterial tyrosine (BY) kinase of P. gingivalis is required for maximal community development and for the production of extracellular polysaccharide. We show that the consensus BY kinase Walker A and B domains, the RK cluster, and the YC domain of Ptk1 are necessary for autophosphorylation and for substrate phosphorylation. Mass spectrometry showed that six tyrosine residues in a 16‐amino‐acid C...
Source: Oral Microbiology and Immunology - September 24, 2016 Category: Microbiology Authors: C. Liu, D.P. Miller, Y. Wang, M. Merchant, R.J. Lamont Tags: Original Article Source Type: research
Tannerella forsythia GroEL induces inflammatory bone resorption and synergizes with interleukin ‐17
This study investigated the potential of T. forsythia GroEL to induce inflammatory bone resorption and examined the cooperative effect of IL‐17 and T. forsythia GroEL on inflammatory responses. Human gingival fibroblasts (HGFs) and periodontal ligament (PDL) fibroblasts were stimulated with T. forsythia GroEL and/or IL‐17. Gene expression of IL‐6, IL‐8, and cyclooxygenase‐2 (COX‐2) and concentrations of IL‐6, IL‐8, and prostaglandin E2 (PGE2) were measured by real‐time reverse transcription polymerase chain reaction and enzyme‐linked immunosorbent assays, respectively. After stimulation of MG63 cell...
Source: Oral Microbiology and Immunology - September 12, 2016 Category: Microbiology Authors: Y. ‐J. Jung, Y.‐J. Choi, S.‐J. An, H.‐R. Lee, H.‐K. Jun, B.‐K. Choi Tags: Original Article Source Type: research
Micro ‐management: curbing chronic wound infection
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Source: Oral Microbiology and Immunology - July 31, 2016 Category: Microbiology Authors: Cathryn Withycombe, Kevin J. Purdy, Sarah E. Maddocks Tags: Invited Review Source Type: research
