Filifactor alocis collagenase can modulate apoptosis of normal oral keratinocytes
This article is protected by copyright. All rights reserved. (Source: Oral Microbiology and Immunology)
Source: Oral Microbiology and Immunology - May 6, 2016 Category: Microbiology Authors: Ozioma Chioma, Wilson Aruni A, Terry‐Ann Milford, Hansel M. Fletcher Tags: Original Article Source Type: research
Collagen ‐binding proteins of Streptococcus mutans and related streptococci
Summary
The ability of Streptococcus mutans to interact with collagen through the expression of collagen‐binding proteins (CBPs) bestows this oral pathogen with an alternative to the sucrose‐dependent mechanism of colonization classically attributed to caries development. Based on the abundance and distribution of collagen throughout the human body, stringent adherence to this molecule grants S. mutans with the opportunity to establish infection at different host sites. Surface proteins, such as SpaP, WapA, Cnm and Cbm, have been shown to bind collagen in vitro, and it has been suggested that these molecules play a r...
Source: Oral Microbiology and Immunology - April 24, 2016 Category: Microbiology Authors: A. Avil és‐Reyes, J.H. Miller, J.A. Lemos, J. Abranches Tags: Review Source Type: research
Collagen‐binding proteins of Streptococcus mutans and related streptococci
Summary
The ability of Streptococcus mutans to interact with collagen through the expression of collagen‐binding proteins (CBPs) bestows this oral pathogen with an alternative to the sucrose‐dependent mechanism of colonization classically attributed to caries development. Based on the abundance and distribution of collagen throughout the human body, stringent adherence to this molecule grants S. mutans with the opportunity to establish infection at different host sites. Surface proteins, such as SpaP, WapA, Cnm and Cbm, have been shown to bind collagen in vitro, and it has been suggested that these molecules play a r...
Source: Oral Microbiology and Immunology - April 24, 2016 Category: Microbiology Authors: A. Avilés‐Reyes, J.H. Miller, J.A. Lemos, J. Abranches Tags: Review Source Type: research
A bacterial ‐biofilm‐induced oral osteolytic infection can be successfully treated by immuno‐targeting an extracellular nucleoid‐associated protein
Summary
Periodontal disease exemplifies a chronic and recurrent infection with a necessary biofilm component. Mucosal inflammation is a hallmark response of the host seen in chronic diseases, such as colitis, gingivitis, and periodontitis (and the related disorder peri‐implantitis). We have taken advantage of our recently developed rat model of human peri‐implantitis that recapitulates osteolysis, the requirement of biofilm formation, and the perpetuation of the bona fide disease state, to test a new therapeutic modality with two novel components. First we used hyperimmune antiserum directed against the DNABII family o...
Source: Oral Microbiology and Immunology - April 4, 2016 Category: Microbiology Authors: M.O. Freire, A. Devaraj, A. Young, J.B. Navarro, J.S. Downey, C. Chen, L.O. Bakaletz, H.H. Zadeh, S.D. Goodman Tags: Original Article Source Type: research
A bacterial‐biofilm‐induced oral osteolytic infection can be successfully treated by immuno‐targeting an extracellular nucleoid‐associated protein
Summary
Periodontal disease exemplifies a chronic and recurrent infection with a necessary biofilm component. Mucosal inflammation is a hallmark response of the host seen in chronic diseases, such as colitis, gingivitis, and periodontitis (and the related disorder peri‐implantitis). We have taken advantage of our recently developed rat model of human peri‐implantitis that recapitulates osteolysis, the requirement of biofilm formation, and the perpetuation of the bona fide disease state, to test a new therapeutic modality with two novel components. First we used hyperimmune antiserum directed against the DNABII family o...
Source: Oral Microbiology and Immunology - April 4, 2016 Category: Microbiology Authors: M.O. Freire, A. Devaraj, A. Young, J.B. Navarro, J.S. Downey, C. Chen, L.O. Bakaletz, H.H. Zadeh, S.D. Goodman Tags: Original Article Source Type: research
Tribute
(Source: Oral Microbiology and Immunology)
Source: Oral Microbiology and Immunology - April 4, 2016 Category: Microbiology Authors: N. Bostanci, T. Thurnheer, G.N. Belibasakis, M.A. Curtis, M. Kilian, P.D. Marsh, D.F. Kinane, A. Mombelli Tags: Tribute Source Type: research
Acid‐Adaptive Mechanisms of Streptococcus mutans – the more we know, the more we don't
This article is protected by copyright. All rights reserved. (Source: Oral Microbiology and Immunology)
Source: Oral Microbiology and Immunology - March 31, 2016 Category: Microbiology Authors: J. L Baker, R. C Faustoferri, R. G Quivey Tags: Invited Review Source Type: research
Differential capacity for complement receptor‐mediated immune evasion by Porphyromonas gingivalis depending on the type of innate leukocyte
This article is protected by copyright. All rights reserved. (Source: Oral Microbiology and Immunology)
Source: Oral Microbiology and Immunology - March 31, 2016 Category: Microbiology Authors: George Hajishengallis, Jennifer L. Krauss, Ravi Jotwani, John D. Lambris Tags: Original Article Source Type: research
Inactivation of the spxA1 or spxA2 gene of Streptococcus mutans decreases virulence in the rat caries model
This article is protected by copyright. All rights reserved. (Source: Oral Microbiology and Immunology)
Source: Oral Microbiology and Immunology - March 31, 2016 Category: Microbiology Authors: Lívia C.C. Galvão, Pedro L. Rosalen, Isamar Rivera‐Ramos, Gilson C.N. Franco, Jessica K Kajfasz, Jacqueline Abranches, Bruno Bueno‐Silva, Hyun Koo, José A. Lemos Tags: Original Article Source Type: research
Invasive Streptococcus mutans induces inflammatory cytokine production in human aortic endothelial cells via regulation of intracellular TLR2 and NOD2
This article is protected by copyright. All rights reserved. (Source: Oral Microbiology and Immunology)
Source: Oral Microbiology and Immunology - March 23, 2016 Category: Microbiology Authors: Emi Nagata, Takahiko Oho Tags: Original Article Source Type: research
The Collagen Binding Proteins of Streptococcus mutans and Related Streptococci
This article is protected by copyright. All rights reserved. (Source: Oral Microbiology and Immunology)
Source: Oral Microbiology and Immunology - March 16, 2016 Category: Microbiology Authors: Alejandro Avilés‐Reyes, James H. Miller, José A. Lemos, Jacqueline Abranches Tags: Review Article Source Type: research
Natural antigenic differences in the functionally equivalent extracellular DNABII proteins of bacterial biofilms provide a means for targeted biofilm therapeutics
This article is protected by copyright. All rights reserved. (Source: Oral Microbiology and Immunology)
Source: Oral Microbiology and Immunology - March 15, 2016 Category: Microbiology Authors: Christopher J. Rocco, Mary Ellen Davey, Lauren O. Bakaletz, Steven D. Goodman Tags: Original Article Source Type: research
Porphyromonas gingivalis induces autophagy in THP ‐1‐derived macrophages
Summary
Autophagy provides a mechanism for the turnover of cellular organelles and proteins through a lysosome‐dependent degradation pathway and is a possible mechanism in inflammatory disease. Periodontitis is an inflammatory disease caused by periodontal pathogens. Porphyromonas gingivalis, an important periodontal pathogen, activates cellular autophagy to provide a replicative niche while suppressing apoptosis in endothelial cells. However, the molecular basis for a causal relationship between P. gingivalis and autophagy is unclear. This research examines the involvement of P. gingivalis in autophagy through light c...
Source: Oral Microbiology and Immunology - February 23, 2016 Category: Microbiology Authors: M.H. Park, S.Y. Jeong, H.S. Na, J. Chung Tags: Original Article Source Type: research
The Porphyromonas gingivalis hemagglutinins HagB and HagC are major mediators of adhesion and biofilm formation
This study highlights the hitherto unappreciated importance of these genes in oral colonization and biofilm formation. (Source: Oral Microbiology and Immunology)
Source: Oral Microbiology and Immunology - February 4, 2016 Category: Microbiology Authors: E. Connolly, E. Millhouse, R. Doyle, S. Culshaw, G. Ramage, G.P. Moran Tags: Original Article Source Type: research
A Bacterial Biofilm Induced Oral Osteolytic Infection Can be Successfully Treated by Immuno‐Targeting an Extracellular Nucleoid Associated Protein
This article is protected by copyright. All rights reserved. (Source: Oral Microbiology and Immunology)
Source: Oral Microbiology and Immunology - February 1, 2016 Category: Microbiology Authors: M O Freire, A Devaraj, A Young, J B Navarro, J S Downey, C Chen, L O Bakaletz, H H Zadeh, S D Goodman Tags: Original Article Source Type: research
