Structure of RagB, a major immunodominant outer‐membrane surface receptor antigen of Porphyromonas gingivalis
This article is protected by copyright. All rights reserved. (Source: Oral Microbiology and Immunology)
Source: Oral Microbiology and Immunology - October 1, 2015 Category: Microbiology Authors: Theodoros Goulas, Irene Garcia Ferrer, Justin A. Hutcherson, Barbara A. Potempa, Jan Potempa, David A. Scott, F. Xavier Gomis‐Rüth Tags: Original Article Source Type: research
Gingipain‐dependent augmentation by Porphyromonas gingivalis of phagocytosis of Tannerella forsythia
This study investigated the role of gingipains in the modulation by P. gingivalis of phagocytosis of Tannerella forsythia by macrophages. Phagocytosis of T. forsythia was significantly enhanced by coinfection with P. gingivalis in a multiplicity of infection‐ and gingipain‐dependent manner. Mutation of either Kgp or Rgp in the coinfecting P. gingivalis resulted in attenuated enhancement of T. forsythia phagocytosis. Inhibition of coaggregation between the two bacterial species reduced phagocytosis of T. forsythia in mixed infection, and this coaggrgation was dependent on gingipains. Inhibition of gingipain protease act...
Source: Oral Microbiology and Immunology - October 1, 2015 Category: Microbiology Authors: Young‐Jung Jung, Hye‐Kyoung Jun, Bong‐Kyu Choi Tags: Original Article Source Type: research
QseBC, a two component bacterial adrenergic receptor and global regulator of virulence in Enterobacteriaceae and Pasteurellaceae
This article is protected by copyright. All rights reserved. (Source: Oral Microbiology and Immunology)
Source: Oral Microbiology and Immunology - October 1, 2015 Category: Microbiology Authors: Whitney A. Weigel, Donald R. Demuth Tags: Review Article Source Type: research
PPARδ inhibits Porphyromonas gingivalis lipopolysaccharide‐induced activation of MMP‐2 by downregulating Nox4 in human gingival fibroblasts
This article is protected by copyright. All rights reserved. (Source: Oral Microbiology and Immunology)
Source: Oral Microbiology and Immunology - September 25, 2015 Category: Microbiology Authors: T. Yoo, S.A. Ham, J.S. Hwang, W.J. Lee, K.S. Paek, J.W. Oh, J.H. Kim, J.T. Do, C.W. Han, J.H. Kim, H.G. Seo Tags: Original Article Source Type: research
Transcriptome analysis of Streptococcus gordonii Challis DL1 indicates a role for the biofilm ‐associated fruRBA operon in response to Candida albicans
Summary
Multiple levels of interkingdom signaling have been implicated in maintaining the ecological balance between Candida albicans and commensal streptococci to assure a state of oral health. To better understand the molecular mechanisms involved in the initial streptococcal response to the presence of C. albicans that can initiate oral surface colonization and biofilm formation, hypha‐forming cells were incubated with Streptococcus gordonii cells for 30 min to assess the streptococcal transcriptome response. A genome‐wide microarray analysis and quantitative polymerase chain reaction validation of S. gordonii tr...
Source: Oral Microbiology and Immunology - September 24, 2015 Category: Microbiology Authors: A.M. Jesionowski, J.M. Mansfield, J.L. Brittan, H.F. Jenkinson, M.M. Vickerman Tags: Original Article Source Type: research
Lymphoid susceptibility to the Aggregatibacter actinomycetemcomitans cytolethal distending toxin is dependent upon baseline levels of the signaling lipid, phosphatidylinositol‐3,4,5‐triphosphate
Summary
The Aggregatibacter actinomycetemcomitans cytolethal distending toxin (Cdt) induces G2 arrest and apoptosis in lymphocytes and other cell types. We have shown that the active subunit, CdtB, exhibits phosphatidylinositol‐3,4,5‐triphosphate (PIP3) phosphatase activity and depletes lymphoid cells of PIP3. Hence we propose that Cdt toxicity results from depletion of this signaling lipid and perturbation of phosphatidylinositol‐3‐kinase (PI‐3K)/PIP3/Akt signaling. We have now focused on the relationship between cell susceptibility to CdtB and differences in the status of baseline PIP3 levels. Our studies demon...
Source: Oral Microbiology and Immunology - September 24, 2015 Category: Microbiology Authors: B.J. Shenker, L.P. Walker, A. Zekavat, K. Boesze‐Battaglia Tags: Original Article Source Type: research
Periodontal and peri ‐implant diseases: identical or fraternal infections?
Summary
Peri‐implant diseases (peri‐implantitis and peri‐implant mucositis) are bacterially driven infections. Peri‐implantitis leads to aggressive bone resorption and eventual loss of the implant. Traditionally, peri‐implantitis was regarded as microbially similar to periodontitis, and translocation of periodontal pathogens into the peri‐implant crevice was considered as a critical factor in disease causation. However, evidence is emerging to suggest that the peri‐implant and periodontal ecosystems differ in many important ways. The purpose of this review is to examine the evidence supporting microbial congr...
Source: Oral Microbiology and Immunology - September 14, 2015 Category: Microbiology Authors: N. Robitaille, D.N. Reed, J.D. Walters, P.S. Kumar Tags: Invited Review Source Type: research
Comparison of inherently essential genes of Porphyromonas gingivalis identified in two transposon sequencing libraries
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Source: Oral Microbiology and Immunology - September 12, 2015 Category: Microbiology Authors: Justin A Hutcherson, Himabindu Gogeneni, Debbie Yoder‐Himes, Erik L. Hendrickson, Murray Hackett, Marvin Whiteley, Richard J. Lamont, David A. Scott Tags: Original Article Source Type: research
Spheres of influence: Porphyromonas gingivalis outer membrane vesicles
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Source: Oral Microbiology and Immunology - September 11, 2015 Category: Microbiology Authors: M.J. Gui, S.G. Dashper, N. Slakeski, Y‐Y. Chen, E.C. Reynolds Tags: Review Article Source Type: research
Aggregatibacter actinomycetemcomitans leukotoxin induces cytosol acidification in LFA‐1 expressing immune cells
This article is protected by copyright. All rights reserved. (Source: Oral Microbiology and Immunology)
Source: Oral Microbiology and Immunology - September 11, 2015 Category: Microbiology Authors: Nataliya Balashova, Anuradha Dhingra, Kathleen Boesze‐Battaglia, Edward T. Lally Tags: Special Issue Source Type: research
TLR4, NOD1 and NOD2 mediate immune recognition of putative newly identified periodontal pathogens
Summary
Periodontitis is a polymicrobial inflammatory disease that results from the interaction between the oral microbiota and the host immunity. Although the innate immune response is important for disease initiation and progression, the innate immune receptors that recognize both classical and putative periodontal pathogens that elicit an immune response have not been elucidated. By using the Human Oral Microbe Identification Microarray (HOMIM), we identified multiple predominant oral bacterial species in human plaque biofilm that strongly associate with severe periodontitis. Ten of the identified species were evaluated...
Source: Oral Microbiology and Immunology - September 10, 2015 Category: Microbiology Authors: J. Marchesan, Y.Z. Jiao, R.A. Schaff, J. Hao, T. Morelli, J.S. Kinney, E. Gerow, R. Sheridan, V. Rodrigues, B.J. Paster, N. Inohara, W.V. Giannobile Tags: Original Article Source Type: research
Inhibition of LtxA Toxicity by Blocking Cholesterol Binding With Peptides
This article is protected by copyright. All rights reserved. (Source: Oral Microbiology and Immunology)
Source: Oral Microbiology and Immunology - September 9, 2015 Category: Microbiology Authors: Angela C. Brown, Evan Koufos, Nataliya Balashova, Kathleen Boesze‐Battaglia, Edward T. Lally Tags: Special Issue Source Type: research
Dental caries‐not just holes in teeth! A perspective
This article is protected by copyright. All rights reserved. (Source: Oral Microbiology and Immunology)
Source: Oral Microbiology and Immunology - September 8, 2015 Category: Microbiology Authors: William H. Bowen Tags: Invited Review Source Type: research
High‐throughput Sequencing Reveals Key Genes and Immune Homeostatic Pathways Activated in Myeloid Dendritic Cells by Porphyromonas gingivalis 381 and its Fimbrial Mutants
In conclusion, we have identified key dendritic cell mediated immune homeostatic pathways that could contribute to dysbiosis in periodontal infection with P. gingivalis.
This article is protected by copyright. All rights reserved. (Source: Oral Microbiology and Immunology)
Source: Oral Microbiology and Immunology - September 7, 2015 Category: Microbiology Authors: Pachiappan Arjunan, Ahmed El‐Awady, Richard O. Dannebaum, Govindarajan Kunde Ramamoorthy, Christopher W Cutler Tags: Special Issue Source Type: research
A putative TetR regulator is involved in Nitric Oxide stress resistance in Porphyromonas gingivalis
This article is protected by copyright. All rights reserved. (Source: Oral Microbiology and Immunology)
Source: Oral Microbiology and Immunology - August 29, 2015 Category: Microbiology Authors: Marie‐Claire Boutrin, Ying Yu, Charles Wang, Wilson Aruni, Yuetan Dou, Leming Shi, Hansel M. Fletcher Tags: Original Article Source Type: research
