Interactions between Streptococcus oralis, Actinomyces oris, and Candida albicans in the development of multispecies oral microbial biofilms on salivary pellicle
This article is protected by copyright. All rights reserved. (Source: Oral Microbiology and Immunology)
Source: Oral Microbiology and Immunology - February 1, 2016 Category: Microbiology Authors: Indira M.G. Cavalcanti, Altair A. Del Bel Cury, Howard F. Jenkinson, Angela H. Nobbs Tags: Original Article Source Type: research
Heme acquisition mechanisms of Porphyromonas gingivalis – strategies used in a polymicrobial community in a heme‐limited host environment
Summary
Porphyromonas gingivalis, a main etiologic agent and key pathogen responsible for initiation and progression of chronic periodontitis requires heme as a source of iron and protoporphyrin IX for its survival and the ability to establish an infection. Porphyromonas gingivalis is able to accumulate a defensive cell‐surface heme‐containing pigment in the form of μ‐oxo bisheme. The main sources of heme for P. gingivalis in vivo are hemoproteins present in saliva, gingival crevicular fluid, and erythrocytes. To acquire heme, P. gingivalis uses several mechanisms. Among them, the best characterized are those emp...
Source: Oral Microbiology and Immunology - January 28, 2016 Category: Microbiology Authors: J.W. Smalley, T. Olczak Tags: Review Source Type: research
Porphyromonas gingivalis induces autophagy in THP‐1‐derived macrophages
This article is protected by copyright. All rights reserved. (Source: Oral Microbiology and Immunology)
Source: Oral Microbiology and Immunology - January 21, 2016 Category: Microbiology Authors: Mi Hee Park, So Yeon Jung, Hee Sam Na, Jin Chung Tags: Original Article Source Type: research
Advances in the microbial etiology and pathogenesis of early childhood caries
This article is protected by copyright. All rights reserved. (Source: Oral Microbiology and Immunology)
Source: Oral Microbiology and Immunology - January 12, 2016 Category: Microbiology Authors: Evlambia Hajishengallis, Yassmin Parsaei, Marlise I. Klein, Hyun Koo Tags: Invited Review Source Type: research
Introduction to the Mark Wilson Conference Special Issue
(Source: Oral Microbiology and Immunology)
Source: Oral Microbiology and Immunology - January 12, 2016 Category: Microbiology Authors: A. Progulske‐Fox, D.H. Fine, R.P. Darveau, H.M. Fletcher Tags: Editorial Source Type: research
The Porphyromonas gingivalis haemagglutinins HagB and HagC are major mediators of adhesion and biofilm formation
This study highlights the hitherto unappreciated importance of these genes in oral colonisation and biofilm formation.
This article is protected by copyright. All rights reserved. (Source: Oral Microbiology and Immunology)
Source: Oral Microbiology and Immunology - December 21, 2015 Category: Microbiology Authors: Eimear Connolly, Emma Millhouse, Rebecca Doyle, Shauna Culshaw, Gordon Ramage, Gary P. Moran Tags: Original Article Source Type: research
Escape from the competence state in Streptococcus mutans is governed by the bacterial population density
The objective of the present work was to help decipher the molecular mechanisms regulating the escape from the competence state in Streptococcus mutans, the principal etiological agent responsible for tooth decay in humans. Our results showed that the cessation of competence in S. mutans was abrupt, and did not involve the accumulation of a competence inhibitor nor the depletion of a competence activator in the extracellular environment. The competence state was repressed at high cell population density via concomitant repression of sigX gene encoding the master regulator of the competence regulon. Co‐culture experiment...
Source: Oral Microbiology and Immunology - December 16, 2015 Category: Microbiology Authors: D. Dufour, C. Villemin, J.A. Perry, C.M. Lévesque Tags: Original Article Source Type: research
Sublingual immunization with the phosphate‐binding‐protein (PstS) reduces oral colonization by Streptococcus mutans
Summary
Bacterial ATP‐binding cassette (ABC) transporters play a crucial role in the physiology and pathogenicity of different bacterial species. Components of ABC transporters have also been tested as target antigens for the development of vaccines against different bacterial species, such as those belonging to the Streptococcus genus. Streptococcus mutans is the etiological agent of dental caries, and previous studies have demonstrated that deletion of the gene encoding PstS, the substrate‐binding component of the phosphate uptake system (Pst), reduced the adherence of the bacteria to abiotic surfaces. In the current...
Source: Oral Microbiology and Immunology - December 2, 2015 Category: Microbiology Authors: E.L. Ferreira, M.T. Batista, R.C.M. Cavalcante, V.R. Pegos, H.M. Passos, D.A. Silva, A. Balan, L.C.S. Ferreira, R.C.C. Ferreira Tags: Original Article Source Type: research
T cells, teeth and tissue destruction – what do T cells do in periodontal disease?
Summary
The microbial plaque biofilm resides adjacent to the tissue‐destructive inflammatory infiltrate in periodontitis. Although not sufficient, this biofilm is necessary for this inflammatory response. Patients with periodontitis generate antibodies specific for bacteria in the biofilm – although the role of these antibodies is not clear, there is, undoubtedly, an adaptive immune response in periodontitis. T lymphocytes are central to adaptive immunity, and provide help for B cells to generate specific antibodies. T‐cell receptor recognition of peptide antigen in the context of major histocompatibility complex can...
Source: Oral Microbiology and Immunology - December 2, 2015 Category: Microbiology Authors: L. Campbell, E. Millhouse, J. Malcolm, S. Culshaw Tags: Review Source Type: research
Secreted adenosine triphosphate from Aggregatibacter actinomycetemcomitans triggers chemokine response
Summary
Extracellular ATP (eATP) is an important intercellular signaling molecule secreted by activated immune cells or released by damaged cells. In mammalian cells, a rapid increase of ATP concentration in the extracellular space sends a danger signal, which alerts the immune system of an impending danger, resulting in recruitment and priming of phagocytes. Recent studies show that bacteria also release ATP into the extracellular milieu, suggesting a potential role for eATP in host–microbe interactions. It is currently unknown if any oral bacteria release eATP. As eATP triggers and amplifies innate immunity and inflamm...
Source: Oral Microbiology and Immunology - December 2, 2015 Category: Microbiology Authors: Q. Ding, S.Y. Quah, K.S. Tan Tags: Original Article Source Type: research
Sublingual immunization with the phosphate ‐binding‐protein (PstS) reduces oral colonization by Streptococcus mutans
Summary
Bacterial ATP‐binding cassette (ABC) transporters play a crucial role in the physiology and pathogenicity of different bacterial species. Components of ABC transporters have also been tested as target antigens for the development of vaccines against different bacterial species, such as those belonging to the Streptococcus genus. Streptococcus mutans is the etiological agent of dental caries, and previous studies have demonstrated that deletion of the gene encoding PstS, the substrate‐binding component of the phosphate uptake system (Pst), reduced the adherence of the bacteria to abiotic surfaces. In the current...
Source: Oral Microbiology and Immunology - December 1, 2015 Category: Microbiology Authors: E.L. Ferreira, M.T. Batista, R.C.M. Cavalcante, V.R. Pegos, H.M. Passos, D.A. Silva, A. Balan, L.C.S. Ferreira, R.C.C. Ferreira Tags: Original Article Source Type: research
d ‐Alanine metabolism is essential for growth and biofilm formation of Streptococcus mutans
In this study, the addition of DCS blocked the d‐Ala metabolic pathway in S. mutans, leading to bacterial cell wall defects, significant inhibition of bacterial growth and biofilm formation, and reductions in extracellular polysaccharide production and bacterial adhesion. However, the exogenous addition of d‐Ala could reverse the inhibitory effect of DCS. Through the means of drug regulation, our study demonstrated, for the first time, the importance of d‐Ala metabolism in the survival and biofilm formation of S. mutans. If the growth of S. mutans can be specifically inhibited by designing drugs that target d‐Al...
Source: Oral Microbiology and Immunology - December 1, 2015 Category: Microbiology Authors: W. Qiu, X. Zheng, Y. Wei, X. Zhou, K. Zhang, S. Wang, L. Cheng, Y. Li, B. Ren, X. Xu, Y. Li, M. Li Tags: Original Article Source Type: research
Streptococcus mutans Copper Chaperone, CopZ, is critical for biofilm formation and competitiveness
This article is protected by copyright. All rights reserved. (Source: Oral Microbiology and Immunology)
Source: Oral Microbiology and Immunology - December 1, 2015 Category: Microbiology Authors: Sandra S. Garcia, Qin Du, Hui Wu Tags: Original Article Source Type: research
Haem acquisition mechanisms of Porphyromonas gingivalis – strategies used in polymicrobial community in a haem‐limited host environment
This article is protected by copyright. All rights reserved. (Source: Oral Microbiology and Immunology)
Source: Oral Microbiology and Immunology - December 1, 2015 Category: Microbiology Authors: John W Smalley, Teresa Olczak Tags: Invited Review Source Type: research
The SloR Metalloregulator is Involved in the Streptococcus mutans Oxidative Stress Response
This article is protected by copyright. All rights reserved. (Source: Oral Microbiology and Immunology)
Source: Oral Microbiology and Immunology - November 20, 2015 Category: Microbiology Authors: Sarah C. Crepps, Emily E. Fields, Diego Galan, John P. Corbett, Elizabeth R. Von Hasseln, Grace A. Spatafora Tags: Special Issue Source Type: research
