Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential
Nature Reviews Neuroscience 19, 138 (2018).
doi:10.1038/nrn.2018.2
Authors: Kazuhide Inoue & Makoto Tsuda
Acute nociceptive pain is a key defence system that enables the detection of danger signals that threaten homeostasis and survival. However, chronic pain (such as the neuropathic pain that occurs after peripheral nerve injury) is not simply a consequence of the continuity of acute nociceptive (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - February 8, 2018 Category: Neuroscience Authors: Kazuhide Inoue Makoto Tsuda Tags: Review Source Type: research
Neural repair: Tagging mRNA drives regeneration
Nature Reviews Neuroscience 19, 121 (2018).
doi:10.1038/nrn.2018.14
Author: Katherine Whalley
A dynamic mRNA modification promotes axon regeneration in injured peripheral sensory neurons. (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - February 8, 2018 Category: Neuroscience Authors: Katherine Whalley Tags: Research Highlight Source Type: research
Spatial processing: An 'other' kind of place cell
Nature Reviews Neuroscience 19, 122 (2018).
doi:10.1038/nrn.2018.12
Author: Natasha Bray
'Social place cells' of the dorsal hippocampal CA1 region in bats and in rats encode the position of an observed conspecific. (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - February 1, 2018 Category: Neuroscience Authors: Natasha Bray Tags: Research Highlight Source Type: research
Cell biology of the neuron: ARC goes viral
Nature Reviews Neuroscience 19, 120 (2018).
doi:10.1038/nrn.2018.9
Author: Natasha Bray
Two recent papers reveal that the activity-regulated cytoskeleton-associated proteins ARC and Drosophila melanogaster dArc1 auto-assemble into mRNA-containing, virus-like capsids that are released by neurons in exosomal vesicles and that can be endocytosed at the postsynaptic compartment. (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - February 1, 2018 Category: Neuroscience Authors: Natasha Bray Tags: Research Highlight Source Type: research
Neural development: 'Enhancing' human cognition
Nature Reviews Neuroscience 19, 120 (2018).
doi:10.1038/nrn.2018.11
Author: Sian Lewis
Human-gained enhancers (regulatory elements in the human genome that are more active in the human lineage) are shown to regulate progenitor proliferation in the outer subventricular zone, an area that is substantially larger in humans compared with other primates. (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - February 1, 2018 Category: Neuroscience Authors: Sian Lewis Tags: Research Highlight Source Type: research
Mitochondria at the neuronal presynapse in health and disease
Nature Reviews Neuroscience 19, 63 (2018).
doi:10.1038/nrn.2017.170
Authors: Michael J. Devine & Josef T. Kittler
Synapses enable neurons to communicate with each other and are therefore a prerequisite for normal brain function. Presynaptically, this communication requires energy and generates large fluctuations in calcium concentrations. Mitochondria are optimized for supplying energy and buffering calcium, and they are actively recruited to presynapses. (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - January 19, 2018 Category: Neuroscience Authors: Michael J. Devine Josef T. Kittler Tags: Review Source Type: research
Neurodegenerative disease: A proteostatic boost
Nature Reviews Neuroscience 19, 61 (2018).
doi:10.1038/nrn.2018.3
Author: Darran Yates
Amyloid-β (Aβ)-induced proteotoxicity is linked to a mitochondrial stress response that may be conserved across species, and promoting mitochondrial proteostasis counteracts Aβ aggregation in worms and an Alzheimer disease mouse model. (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - January 19, 2018 Category: Neuroscience Authors: Darran Yates Tags: Research Highlight Source Type: research
Neuroimmunology: Brain police
Nature Reviews Neuroscience 19, 60 (2018).
doi:10.1038/nrn.2018.5
Author: Sian Lewis
Microglial surveillance of the brain is dependent on maintenance of microglia membrane potential by the K+ channel THIK1, which is potentiated by ATP released at sites of tissue injury acting on P2Y12 receptors. (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - January 19, 2018 Category: Neuroscience Authors: Sian Lewis Tags: Research Highlight Source Type: research
Learning and memory: You only learn once
Nature Reviews Neuroscience 19, 59 (2018).
doi:10.1038/nrn.2018.4
Author: Natasha Bray
When mice explore a new context, neurons in the locus coeruleus that project to hippocampal regions CA3 enable the learning of the new environment. (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - January 19, 2018 Category: Neuroscience Authors: Natasha Bray Tags: Research Highlight Source Type: research
Dual function of thalamic low-vigilance state oscillations: rhythm-regulation and plasticity
Nature Reviews Neuroscience 19, 107 (2018).
doi:10.1038/nrn.2017.151
Authors: Vincenzo Crunelli, Magor L. Lőrincz, William M. Connelly, François David, Stuart W. Hughes, Régis C. Lambert, Nathalie Leresche & Adam C. Errington
During inattentive wakefulness and non-rapid eye movement (NREM) sleep, the neocortex and thalamus cooperatively engage in rhythmic activities that are exquisitely reflected in the electroencephalogram as distinctive rhythms spanning a range of frequencies from (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - January 11, 2018 Category: Neuroscience Authors: Vincenzo Crunelli Magor L. L ő rincz William M. Connelly Fran ç ois David Stuart W. Hughes R é gis C. Lambert Nathalie Leresche Adam C. Errington Tags: Perspectives Source Type: research
Leptin and the maintenance of elevated body weight
Nature Reviews Neuroscience 19, 95 (2018).
doi:10.1038/nrn.2017.168
Authors: Warren W. Pan & Martin G. Myers
Obesity represents the single most important risk factor for early disability and death in developed societies, and the incidence of obesity remains at staggering levels. CNS systems that modulate energy intake and expenditure in response to changes in body energy stores serve to maintain constant (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - January 11, 2018 Category: Neuroscience Authors: Warren W. Pan Martin G. Myers Tags: Review Source Type: research
Intermittent metabolic switching, neuroplasticity and brain health
Nature Reviews Neuroscience 19, 63 (2018).
doi:10.1038/nrn.2017.156
Authors: Mark P. Mattson, Keelin Moehl, Nathaniel Ghena, Maggie Schmaedick & Aiwu Cheng
During evolution, individuals whose brains and bodies functioned well in a fasted state were successful in acquiring food, enabling their survival and reproduction. With fasting and extended exercise, liver glycogen stores are depleted and ketones are produced from adipose-cell-derived fatty acids. This metabolic switch in (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - January 11, 2018 Category: Neuroscience Authors: Mark P. Mattson Keelin Moehl Nathaniel Ghena Maggie Schmaedick Aiwu Cheng Tags: Review Source Type: research
Neural coding: Investigating social spaces
Nature Reviews Neuroscience 19, 60 (2018).
doi:10.1038/nrn.2017.169
Author: Natasha Bray
In mice, projections from the prelimbic cortex to the nucleus accumbens encode a combination of social and spatial information and may promote 'social investigation' behaviour by enabling social–spatial learning. (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - December 21, 2017 Category: Neuroscience Authors: Natasha Bray Tags: Research Highlight Source Type: research
Synaptic transmission: Closer encounters
Nature Reviews Neuroscience 19, 58 (2018).
doi:10.1038/nrn.2017.167
Author: Sian Lewis
Synaptic transmission (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - December 14, 2017 Category: Neuroscience Authors: Sian Lewis Tags: Erratum Source Type: research
Axo-myelinic neurotransmission: a novel mode of cell signalling in the central nervous system
Nature Reviews Neuroscience 19, 58 (2018).
doi:10.1038/nrn.2017.166
Author: Ileana Micu, Jason R. Plemel, Andrew V. Caprariello, Klaus-Armin Nave & Peter K. Stys
Nature Reviews Neuroscience19, 49–57 (2018)In this Opinion article, the first names of the authors did not appear. The error has been corrected in the online versions of the article. The editors apologize to the authors and readers (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - December 14, 2017 Category: Neuroscience Authors: Ileana Micu Jason R. Plemel Andrew V. Caprariello Klaus-Armin Nave Peter K. Stys Tags: Erratum Source Type: research
