Synaptic transmission: Closer encounters
Nature Reviews Neuroscience 19, 5 (2018).
doi:10.1038/nrn.2017.150
Author: Sian Lewis
At hippocampal mossy fibre synapses, depolarization-induced facilitation of vesicle release occurs via a cAMP-dependent increase in coupling between Ca2+ channels and vesicle release machinery. (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - November 30, 2017 Category: Neuroscience Authors: Sian Lewis Tags: Research Highlight Source Type: research
Lineage divergence of activity-driven transcription and evolution of cognitive ability
Nature Reviews Neuroscience 19, 9 (2018).
doi:10.1038/nrn.2017.138
Authors: Giles E. Hardingham, Priit Pruunsild, Michael E. Greenberg & Hilmar Bading
Excitation–transcription coupling shapes network formation during brain development and controls neuronal survival, synaptic function and cognitive skills in the adult. New studies have uncovered differences in the transcriptional responses to synaptic activity between humans and mice. These differences are caused both by the emergence of (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - November 23, 2017 Category: Neuroscience Authors: Giles E. Hardingham Priit Pruunsild Michael E. Greenberg Hilmar Bading Tags: Progress Source Type: research
Neuromodulation: On the alert
Nature Reviews Neuroscience 19, 4 (2018).
doi:10.1038/nrn.2017.148
Author: Katherine Whalley
A method that integrates whole-brain neural activity measurements with cellular-level molecular phenotyping is used to investigate the neuronal populations that modulate a global brain state. (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - November 23, 2017 Category: Neuroscience Authors: Katherine Whalley Tags: Research Highlight Source Type: research
The nano-architecture of the axonal cytoskeleton
Nature Reviews Neuroscience 19, 58 (2018).
doi:10.1038/nrn.2017.147
Author: Christophe Leterrier, Pankaj Dubey & Subhojit Roy
Nature Reviews Neuroscience18, 713–726 (2017)In Box 1 of this article, the sentence “Actin filaments are approximately 8 nm in diameter, are composed of heterodimers of α-actin and β-actin (known as G-actin) and require ATP for polymerization” should (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - November 16, 2017 Category: Neuroscience Authors: Christophe Leterrier Pankaj Dubey Subhojit Roy Tags: Corrigendum Source Type: research
Visual processing: Silent motion detectors
Nature Reviews Neuroscience 19, 4 (2018).
doi:10.1038/nrn.2017.146
Author: Natasha Bray
'Silent' synapses enable motion detection by retinal direction-selective ganglion cells at near-threshold contrasts. (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - November 16, 2017 Category: Neuroscience Authors: Natasha Bray Tags: Research Highlight Source Type: research
Regenerating CNS myelin — from mechanisms to experimental medicines
Nature Reviews Neuroscience 18, 753 (2017).
doi:10.1038/nrn.2017.136
Authors: Robin J. M. Franklin & Charles ffrench-Constant
Although the core concept of remyelination — based on the activation, migration, proliferation and differentiation of CNS progenitors — has not changed over the past 20 years, our understanding of the detailed mechanisms that underlie this process has developed considerably. We can now decorate the (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - November 16, 2017 Category: Neuroscience Authors: Robin J. M. Franklin Charles ffrench-Constant Tags: Review Source Type: research
The dopamine motive system: implications for drug and food addiction
Nature Reviews Neuroscience 18, 741 (2017).
doi:10.1038/nrn.2017.130
Authors: Nora D. Volkow, Roy A. Wise & Ruben Baler
Behaviours such as eating, copulating, defending oneself or taking addictive drugs begin with a motivation to initiate the behaviour. Both this motivational drive and the behaviours that follow are influenced by past and present experience with the reinforcing stimuli (such as drugs or energy-rich foods) (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - November 16, 2017 Category: Neuroscience Authors: Nora D. Volkow Roy A. Wise Ruben Baler Tags: Review Source Type: research
Axo-myelinic neurotransmission: a novel mode of cell signalling in the central nervous system
Nature Reviews Neuroscience 19, 49 (2018).
doi:10.1038/nrn.2017.128
Authors: I. Micu, J. R. Plemel, A. V. Caprariello, K.-A. Nave & P. K. Stys
It is widely recognized that myelination of axons greatly enhances the speed of signal transmission. An exciting new finding is the dynamic communication between axons and their myelin-forming oligodendrocytes, including activity-dependent signalling from axon to myelin. The oligodendrocyte–myelin complex may in turn respond by providing (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - November 9, 2017 Category: Neuroscience Authors: I. Micu J. R. Plemel A. V. Caprariello K.-A. Nave P. K. Stys Tags: Perspectives Source Type: research
Neural circuits: Shock signals
Nature Reviews Neuroscience 18, 710 (2017).
doi:10.1038/nrn.2017.145
Author: Natasha Bray
In fear conditioning in mice, neurons in the lateral central amygdala that express protein kinase Cδ convey the unconditioned stimulus to the lateral amygdala to enable the encoding of aversive memory. (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - November 9, 2017 Category: Neuroscience Authors: Natasha Bray Tags: Research Highlight Source Type: research
Epigenetics: Leaving a lasting mark
Nature Reviews Neuroscience 18, 710 (2017).
doi:10.1038/nrn.2017.144
Author: Katherine Whalley
Methylation of neuronal genes at CA sequences is modulated by neuronal activity during early postnatal periods and fine tunes gene expression in adult neurons. (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - November 9, 2017 Category: Neuroscience Authors: Katherine Whalley Tags: Research Highlight Source Type: research
Only the PAM explains the personalized nature of empathy
Nature Reviews Neuroscience 18, 769 (2017).
doi:10.1038/nrn.2017.140
Authors: Stephanie D. Preston & Frans B. M. de Waal
Responding to our Review (Mammalian empathy: behavioural manifestations and neural basis. Nat. Rev. Neurosci.18, 498–509; 2017), Rizzolatti and Caruana (Some considerations on de Waal and Preston review. http://dx.doi.org/10.1038/nrn.2017.139(2017)) state that their “mirror mechanism” is “not complementary to the PAM, (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - November 3, 2017 Category: Neuroscience Authors: Stephanie D. Preston Frans B. M. de Waal Tags: Reply Source Type: research
Some considerations on de Waal and Preston review
Nature Reviews Neuroscience 18, 769 (2017).
doi:10.1038/nrn.2017.139
Authors: Giacomo Rizzolatti & Fausto Caruana
In their interesting Review, de Waal and Preston propose that the emotional states of others are “understood through personal, embodied representations that allow empathy” (Nat. Rev. Neurosci.18, 498–509 (2017)). One of the key pieces of neuroscientific evidence for such a (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - November 3, 2017 Category: Neuroscience Authors: Giacomo Rizzolatti Fausto Caruana Tags: Correspondence Source Type: research
The nano-architecture of the axonal cytoskeleton
Nature Reviews Neuroscience 18, 713 (2017).
doi:10.1038/nrn.2017.129
Authors: Christophe Leterrier, Pankaj Dubey & Subhojit Roy
The corporeal beauty of the neuronal cytoskeleton has captured the imagination of generations of scientists. One of the easiest cellular structures to visualize by light microscopy, its existence has been known for well over 100 years, yet we have only recently begun to fully appreciate (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - November 3, 2017 Category: Neuroscience Authors: Christophe Leterrier Pankaj Dubey Subhojit Roy Tags: Review Source Type: research
Learning and memory: Holding the space
Nature Reviews Neuroscience 18, 711 (2017).
doi:10.1038/nrn.2017.143
Author: Sian Lewis
Spatial position is spontaneously stored as part of working memory, even in tasks where spatial location is not relevant to the task. (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - November 3, 2017 Category: Neuroscience Authors: Sian Lewis Tags: Research Highlight Source Type: research
Neural coding: Flexible in the face of distraction
Nature Reviews Neuroscience 18, 709 (2017).
doi:10.1038/nrn.2017.142
Author: Natasha Bray
In a working memory task, the neural code for the target stimulus in the lateral prefrontal cortex transforms when a distractor is presented, without loss of target-related information. (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - November 3, 2017 Category: Neuroscience Authors: Natasha Bray Tags: Research Highlight Source Type: research
