Neurodegenerative disease: A mechanism for missing memory
Nature Reviews Neuroscience 17, 670 (2016).
doi:10.1038/nrn.2016.142
Author: Natasha Bray
A loss of cholinergic inputs to the hippocampus in a mouse model of Alzheimer disease leads to memory deficits by affecting interneurons in the oriens lacunosum moleculare. (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - October 17, 2016 Category: Neuroscience Authors: Natasha Bray Tags: Research Highlight Source Type: research
How do we know what we know? Discovering neuroscience data sets through minimal metadata
Nature Reviews Neuroscience 17, 735 (2016).
doi:10.1038/nrn.2016.134
Author: Sean L. Hill
With the emergence of brain research initiatives around the world, the need for standards to facilitate neuroscience data sharing is growing. A crucial first step will be to establish a minimal metadata standard that allows the discovery of and access to similar or related data (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - October 12, 2016 Category: Neuroscience Authors: Sean L. Hill Tags: Comment Source Type: research
Spatial genome organization and cognition
Nature Reviews Neuroscience 17, 681 (2016).
doi:10.1038/nrn.2016.124
Authors: Prashanth Rajarajan, Sergio Espeso Gil, Kristen J. Brennand & Schahram Akbarian
Nonrandom chromosomal conformations, including promoter–enhancer loopings that bypass kilobases or megabases of linear genome, provide a crucial layer of transcriptional regulation and move vast amounts of non-coding sequence into the physical proximity of genes that are important for neurodevelopment, cognition and behaviour. Activity-regulated changes in (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - October 5, 2016 Category: Neuroscience Authors: Prashanth Rajarajan Sergio Espeso Gil Kristen J. Brennand Schahram Akbarian Tags: Review Source Type: research
Reward: Calculating error
Nature Reviews Neuroscience 17, 670 (2016).
doi:10.1038/nrn.2016.139
Author: Natasha Bray
Inputs to the ventral tegmental area, which computes the reward prediction error, carry diverse signals about the actual and expected reward from distributed areas. (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - September 28, 2016 Category: Neuroscience Authors: Natasha Bray Tags: Research Highlight Source Type: research
How can brain mapping initiatives cooperate to achieve the same goal?
Nature Reviews Neuroscience 17, 733 (2016).
doi:10.1038/nrn.2016.126
Authors: Hideyuki Okano & Tetsuo Yamamori
The independent worldwide brain-research initiatives should collaborate in order to enable them to reach their shared goal: gaining a better understanding of the tremendous complexity of the human brain. (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - September 21, 2016 Category: Neuroscience Authors: Hideyuki Okano Tetsuo Yamamori Tags: Comment Source Type: research
Mind-wandering as spontaneous thought: a dynamic framework
Nature Reviews Neuroscience 17, 718 (2016).
doi:10.1038/nrn.2016.113
Authors: Kalina Christoff, Zachary C. Irving, Kieran C. R. Fox, R. Nathan Spreng & Jessica R. Andrews-Hanna
Most research on mind-wandering has characterized it as a mental state with contents that are task unrelated or stimulus independent. However, the dynamics of mind-wandering — how mental states change over time — have remained largely neglected. Here, we introduce a dynamic framework for understanding (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - September 21, 2016 Category: Neuroscience Authors: Kalina Christoff Zachary C. Irving Kieran C. R. Fox R. Nathan Spreng Jessica R. Andrews-Hanna Tags: Review Source Type: research
Neuronal development: Signalling synaptogenesis
Nature Reviews Neuroscience 17, 670 (2016).
doi:10.1038/nrn.2016.137
Author: Sian Lewis
Early in development, GABA released from interneurons is excitatory and induces the formation of functional inhibitory and excitatory synapses in cortical layer 2/3. (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - September 21, 2016 Category: Neuroscience Authors: Sian Lewis Tags: Research Highlight Source Type: research
Adult neurogenesis: Encouraging integration
Nature Reviews Neuroscience 17, 669 (2016).
doi:10.1038/nrn.2016.136
Author: Katherine Whalley
Adult neurogenesis in the hippocampus is regulated by existing hippocampal connectivity and can be manipulated to enhance memory function in aged mice. (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - September 21, 2016 Category: Neuroscience Authors: Katherine Whalley Tags: Research Highlight Source Type: research
The effects of childhood maltreatment on brain structure, function and connectivity
Nature Reviews Neuroscience 17, 652 (2016).
doi:10.1038/nrn.2016.111
Authors: Martin H. Teicher, Jacqueline A. Samson, Carl M. Anderson & Kyoko Ohashi
Maltreatment-related childhood adversity is the leading preventable risk factor for mental illness and substance abuse. Although the association between maltreatment and psychopathology is compelling, there is a pressing need to understand how maltreatment increases the risk of psychiatric disorders. Emerging evidence suggests that maltreatment alters (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - September 18, 2016 Category: Neuroscience Authors: Martin H. Teicher Jacqueline A. Samson Carl M. Anderson Kyoko Ohashi Tags: Review Source Type: research
An interview with...: The Kavli prize winners
Nature Reviews Neuroscience 17, 606 (2016).
doi:10.1038/nrn.2016.127
Interviews with this year's winners of the Kavli prize in neuroscience, Eve Marder, Michael M. Merzenich and Carla J. Shatz. (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - September 18, 2016 Category: Neuroscience Tags: Research Highlight Source Type: research
Techniques: Neuronal barcoding
Nature Reviews Neuroscience 17, 605 (2016).
doi:10.1038/nrn.2016.133
Author: Darran Yates
Mapping long-range neuronal projections with high resolution and high throughput has proved difficult. In an attempt to achieve this goal, Kebschull et al. developed a method termed multiplex analysis of projections by sequencing (MAP-seq). In mice, they injected the locus coeruleus (LC) with a (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - September 18, 2016 Category: Neuroscience Authors: Darran Yates Tags: Research Highlight Source Type: research
Cerebral cortex: Cortical connections
Nature Reviews Neuroscience 17, 605 (2016).
doi:10.1038/nrn.2016.132
Author: Darran Yates
Dum et al. explored which cortical areas may be involved in cognitive control of the stress response by injecting rabies virus into the adrenal medulla — which secretes hormones as part of this response — of non-human primates and assessing its retrograde transport. Two (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - September 18, 2016 Category: Neuroscience Authors: Darran Yates Tags: Research Highlight Source Type: research
Neurophysiology: Inhibitory consumption
Nature Reviews Neuroscience 17, 605 (2016).
doi:10.1038/nrn.2016.131
Author: Darran Yates
Orexin neurons have been suggested to stimulate eating; however, loss of these cells in mice leads to obesity. Here, the authors used fibre photometry to measure calcium signalling in orexin neurons in freely behaving fasted and fed mice and found that the activity of these (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - September 18, 2016 Category: Neuroscience Authors: Darran Yates Tags: Research Highlight Source Type: research
Ion channels: A warm response
Nature Reviews Neuroscience 17, 605 (2016).
doi:10.1038/nrn.2016.130
Author: Darran Yates
How warmth is detected is not fully understood at the molecular level. Here, the authors identified neuronal subpopulations in dorsal root ganglion (DRG) and sympathetic neuron cultures that responded to non-painful heat but not to agonists of transient receptor potential (TRP) ion channels that are (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - September 18, 2016 Category: Neuroscience Authors: Darran Yates Tags: Research Highlight Source Type: research
Neural development: Sight development
Nature Reviews Neuroscience 17, 603 (2016).
doi:10.1038/nrn.2016.129
Author: Natasha Bray
Two studies show that cortical feedback and metabotropic glutamate receptor 1 are necessary for the proper refinement of reticulogeniculate synapses during visual system development. (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - September 18, 2016 Category: Neuroscience Authors: Natasha Bray Tags: Research Highlight Source Type: research
