Spatial genome organization and cognition

Nature Reviews Neuroscience 17, 681 (2016).
doi:10.1038/nrn.2016.124

Authors: Prashanth Rajarajan, Sergio Espeso Gil, Kristen J. Brennand & Schahram Akbarian
Nonrandom chromosomal conformations, including promoter–enhancer loopings that bypass kilobases or megabases of linear genome, provide a crucial layer of transcriptional regulation and move vast amounts of non-coding sequence into the physical proximity of genes that are important for neurodevelopment, cognition and behaviour. Activity-regulated changes in

Source: Nature Reviews Neuroscience - October 5, 2016 Category: Neuroscience Authors: Prashanth Rajarajan Sergio Espeso Gil Kristen J. Brennand Schahram Akbarian Tags: Review Source Type: research