Mutation Research Reviews in Mutation Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

William F. Morgan (1952–2015)
Publication date: Available online 13 July 2016 Source:Mutation Research/Reviews in Mutation Research Author(s): Nobuyuki Hamada, Tom K. Hei, Simon Bouffler, Gayle E. Woloschak (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - July 13, 2016 Category: Genetics & Stem Cells Source Type: research

Effects of Ionizing Radiation on the Heart
This article provides an overview of studies addressing effects of ionizing radiation on the heart. Clinical studies have identified early and late manifestations of radiation-induced heart disease, a side effect of radiation therapy to tumors in the chest when all or part of the heart is situated in the radiation field. Studies in preclinical animal models have contributed to our understanding of the mechanisms by which radiation may injure the heart. More recent observations in human subjects suggest that ionizing radiation may have cardiovascular effects at lower doses than was previously thought. This has led to examin...
Source: Mutation Research Reviews in Mutation Research - July 10, 2016 Category: Genetics & Stem Cells Source Type: research

Human papillomavirus molecular biology
Publication date: Available online 5 July 2016 Source:Mutation Research/Reviews in Mutation Research Author(s): Mallory E. Harden, Karl Munger Human papillomaviruses are small DNA viruses with a tropism for squamous epithelia. A unique aspect of human papillomavirus molecular biology involves dependence on the differentiation status of the host epithelial cell to complete the viral lifecycle. A small group of these viruses are the etiologic agents of several types of human cancers, including oral and anogenital tract carcinomas. This review focuses on the basic molecular biology of human papillomaviruses. (Source: ...
Source: Mutation Research Reviews in Mutation Research - July 5, 2016 Category: Genetics & Stem Cells Source Type: research

DNA repair mechanisms and their clinical impact in glioblastoma
Publication date: Available online 21 June 2016 Source:Mutation Research/Reviews in Mutation Research Author(s): Hélène Erasimus, Matthieu Gobin, Simone Niclou, Eric Van Dyck Despite surgical resection and genotoxic treatment with ionizing radiation and the DNA alkylating agent temozolomide, glioblastoma remains one of the most lethal cancers, due in great part to the action of DNA repair mechanisms that drive resistance and tumor relapse. Understanding the molecular details of these mechanisms and identifying potential pharmacological targets have emerged as vital tasks to improve treatment. In this review, ...
Source: Mutation Research Reviews in Mutation Research - June 23, 2016 Category: Genetics & Stem Cells Source Type: research

Clinical relevance and implications of HPV-induced neoplasia in different anatomical locations
This article reviews the current state and new developments in epidemiology, prevention, diagnosis and treatment of HPV-associated neoplasia in various anatomic locations. (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - June 23, 2016 Category: Genetics & Stem Cells Source Type: research

The cytokinesis-block micronucleus (CBMN) assay in human populations exposed to styrene. A systematic review and meta-analysis.
Publication date: Available online 23 June 2016 Source:Mutation Research/Reviews in Mutation Research Author(s): Solange Costa, Marcello Ceppi, Carla Costa, Susana Silva, Cristiana Pereira, Blanca Laffon, Stefano Bonassi, João Paulo Teixeira Styrene is a building-block of several compounds used in a wide array of materials and products. The most important human exposure to this substance occurs in industrial settings, especially among reinforced-plastics industry workers. The effect of occupational exposure to styrene on cytogenetics biomarkers has been previously reviewed with positive association obs...
Source: Mutation Research Reviews in Mutation Research - June 23, 2016 Category: Genetics & Stem Cells Source Type: research

The ubiquitin family meets the Fanconi anemia proteins
Publication date: Available online 23 June 2016 Source:Mutation Research/Reviews in Mutation Research Author(s): Renaudin Xavier, Lerner Leticia Koch, Menck Carlos Frederico Martins, Rosselli Filippo Fanconi anaemia (FA) is a hereditary disorder that is characterized by bone marrow failure, developmental defects, predisposition to cancer and chromosomal abnormalities. FA is caused by biallelic mutations that inactivate genes encoding proteins involved in replication stress-associated DNA damage responses. The 20 FANC proteins identified to date constitute the FANC pathway. A key event in this pathway involves t...
Source: Mutation Research Reviews in Mutation Research - June 23, 2016 Category: Genetics & Stem Cells Source Type: research

Radiation and Cataract Risk: Impact of Recent Epidemiologic Studies on ICRP Judgments
Publication date: Available online 23 June 2016 Source:Mutation Research/Reviews in Mutation Research Author(s): Roy E. Shore In its 2012 report on tissue reactions, the International Commission on Radiological Protection (ICRP) made several key assumptions regarding radiation risk to the lens of the eye, including that radiation-related minor opacities will progress to become vision-impairing cataracts, that protracted irradiation confers as much risk per unit dose as an acute exposure, and that there is a dose threshold for cataract effects at about 0.5Gy. The few studies available provide only limited support for ...
Source: Mutation Research Reviews in Mutation Research - June 23, 2016 Category: Genetics & Stem Cells Source Type: research

Mutations of myelodysplastic syndromes (MDS): An update
Publication date: Available online 23 June 2016 Source:Mutation Research/Reviews in Mutation Research Author(s): Bani Bandana Ganguly, N.N. Kadam The plethora of knowledge gained on myelodysplastic syndromes (MDS), a heterogeneous pre-malignant disorder of hematopoietic stem cells, through sequencing of several pathway genes has unveiled molecular pathogenesis and its progression to AML. Evolution of phenotypic classification and risk-stratification based on peripheral cytopenias and blast count has moved to five-tier risk-groups solely concerning chromosomal aberrations. Increased frequency of complex abnormalitie...
Source: Mutation Research Reviews in Mutation Research - June 23, 2016 Category: Genetics & Stem Cells Source Type: research

Special Issue: Tissue Reactions to Ionizing Radiation Exposure
Publication date: Available online 18 June 2016 Source:Mutation Research/Reviews in Mutation Research Author(s): Nobuyuki Hamada, Simon Bouffler, Gayle E. Woloschak (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - June 17, 2016 Category: Genetics & Stem Cells Source Type: research

Functional Implications of the spectrum of BCL2 mutations in Lymphoma
Publication date: Available online 16 June 2016 Source:Mutation Research/Reviews in Mutation Research Author(s): Khushboo Singh, James M. Briggs Mutations in the translocated BCL2 gene are often detected in diffuse large B-cell lymphomas (DLBCLs), indicating both their significance and pervasiveness. Large series genome sequencing of more than 200 DLBCLs has identified frequent BCL2 mutations clustered in the exons coding for the BH4 domain and the folded loop domain (FLD) of the protein. However, BCL2 mutations are mostly contemplated to represent bystander events with negligible functional impact on the pathogene...
Source: Mutation Research Reviews in Mutation Research - June 16, 2016 Category: Genetics & Stem Cells Source Type: research

Molecular mechanisms by which in vivo exposure to exogenous chemical genotoxic agents can lead to micronucleus formation in lymphocytes in vivo and ex vivo in humans
Publication date: Available online 7 June 2016 Source:Mutation Research/Reviews in Mutation Research Author(s): Michael Fenech, Siegfried Knasmueller, Claudia Bolognesi, Stefano Bonassi, Nina Holland, Lucia Migliore, Fabrizio Palitti, Adayapalam T. Natarajan, Micheline Kirsch-Volders The purpose of this review is to summarise current knowledge on the molecular mechanisms by which in vivo exposure to exogenous chemical genotoxins in humans induces micronuclei (MNi) and other nuclear anomalies in lymphocytes in vivo and ex vivo after nuclear division in vitro. MNi originate from acentric chromosome frag...
Source: Mutation Research Reviews in Mutation Research - June 7, 2016 Category: Genetics & Stem Cells Source Type: research

The use of the lymphocyte cytokinesis-block micronucleus assay for monitoring pesticide-exposed populations
Publication date: Available online 26 May 2016 Source:Mutation Research/Reviews in Mutation Research Author(s): Claudia Bolognesi, Nina Holland Pesticides are widely used around the world, and hundreds of millions of people are exposed annually in occupational and environmental settings. Numerous studies have demonstrated relationships between pesticide exposure and increased risk of cancers, neurodegenerative and neurodevelopmental disorders, respiratory diseases and diabetes. Assessment of genotoxicity of pesticides and biomonitoring their effects in exposed populations is critical for a better regulation and pro...
Source: Mutation Research Reviews in Mutation Research - May 26, 2016 Category: Genetics & Stem Cells Source Type: research

Use of the lymphocyte cytokinesis-block micronucleus assay in occupational biomonitoring of genome damage caused by in vivo exposure to chemical genotoxins: past, present and future
This article concerns the use of the lymphocyte cytokinesis-block micronucleus (CBMN) assay in biomonitoring of occupational and environmental exposures to genotoxic agents. Furthermore, we evaluated the use of this method in different exposure scenarios, in comparison to other DNA damage biomarkers and its regional distribution. So far ca. 400 studies have been published and the number increased substantially in the last years. The most frequently investigated groups are hospital personnel, followed by workers in the chemical industry and agricultural workers. The lymphocyte CBMN assay is more frequently used in occupatio...
Source: Mutation Research Reviews in Mutation Research - May 20, 2016 Category: Genetics & Stem Cells Source Type: research

Genotoxicity of Ethylene oxide: A review of micronucleus assay results in human population
Publication date: Available online 20 May 2016 Source:Mutation Research/Reviews in Mutation Research Author(s): Manosij Ghosh, Lode Godderis Ethylene oxide (EtO) has been categorized as “carcinogenic to humans (Group 1)” by the IARC. While several epidemiological studies have reported carcinogenicity and EtO-Hb formation; information from cytogenetic endpoints are rather inconclusive. In the present review, we focus on the results of eleven studies which have reported the results of micronucleus assay in EtO exposed workers. We have critically reviewed these studies based on the exposure assessment, concentrati...
Source: Mutation Research Reviews in Mutation Research - May 20, 2016 Category: Genetics & Stem Cells Source Type: research