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HPV entry into cells
Publication date: Available online 23 September 2016 Source:Mutation Research/Reviews in Mutation Research Author(s): Pinar Aksoy, Elinor Y. Gottschalk, Patricio I. Meneses Human papillomavirus (HPV) is a sexually transmitted virus responsible for the development of cervical cancer, anal cancer, head and throat cancers, as well as genital area warts. A major focus of current HPV research is on preventing the virus from entering a cell and transferring its genetic material to the nucleus, thus potentially preventing the development of cancer. Although the available HPV vaccines are extremely successful, approximately 1...
Source: Mutation Research Reviews in Mutation Research - October 3, 2016 Category: Genetics & Stem Cells Source Type: research

Effects of ionizing radiation on the mammalian brain
Publication date: Available online 13 August 2016 Source:Mutation Research/Reviews in Mutation Research Author(s): Daniela Hladik, Soile Tapio Epidemiological studies on the atomic-bomb survivors, cancer survivors and occupational cohorts provide strong evidence for multifaceted damage to brain after ionizing radiation. Radiation-induced late effects may manifest as brain tumors or cognitive impairment. Decreased neurogenesis and differentiation, alteration in neural structure and synaptic plasticity as well as increased oxidative stress and inflammation are suggested to contribute to adverse effects in the brain. In a...
Source: Mutation Research Reviews in Mutation Research - September 23, 2016 Category: Genetics & Stem Cells Source Type: research

TITLE: HPV entry into cells
Publication date: Available online 23 September 2016 Source:Mutation Research/Reviews in Mutation Research Author(s): Pinar Aksoy, Elinor Y. Gottschalk, Patricio I. Meneses Human papillomavirus (HPV) is a sexually transmitted virus responsible for the development of cervical cancer, anal cancer, head and throat cancers, as well as genital area warts. A major focus of current HPV research is on preventing the virus from entering a cell and transferring its genetic material to the nucleus, thus potentially preventing the development of cancer. Although the available HPV vaccines are extremely successful, approximately 1...
Source: Mutation Research Reviews in Mutation Research - September 22, 2016 Category: Genetics & Stem Cells Source Type: research

Special Issue “ HPV and IGF axis in carcinogenesis”
Publication date: Available online 21 September 2016 Source:Mutation Research/Reviews in Mutation Research Author(s): Julia Durzyńska (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - September 21, 2016 Category: Genetics & Stem Cells Source Type: research

Human papillomaviruses in epigenetic regulations
In this study, we have undertaken to discuss a number of studies concerning epigenetic regulations in HPV-dependent cells and to focus on those that have biological relevance to cancer progression. (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - September 19, 2016 Category: Genetics & Stem Cells Source Type: research

Clinical studies in humans targeting the various components of the IGF system show lack of efficacy in the treatment of cancer
Publication date: Available online 19 September 2016 Source:Mutation Research/Reviews in Mutation Research Author(s): Anastassios Philippou, Panagiotis F. Christopoulos, Dr. Michael Koutsilieris The insulin-like growth factors (IGFs) system regulates cell growth, differentiation and energy metabolism and plays crucial role in the regulation of key aspects of tumor biology, such as cancer cell growth, survival, transformation and invasion. The current focus for cancer therapeutic approaches has shifted from the conventional treatments towards the targeted therapies and the IGF system has gained a great interest as anti...
Source: Mutation Research Reviews in Mutation Research - September 19, 2016 Category: Genetics & Stem Cells Source Type: research

Discriminating RNA variants with single-molecule allele-specific FISH
Publication date: Available online 14 September 2016 Source:Mutation Research/Reviews in Mutation Research Author(s): Martyna O. Urbanek, Wlodzimierz J. Krzyzosiak DNA mutations of various types often affect the cellular localization and function of gene products. The role of mutant transcripts in the pathogenesis of human disease is increasingly recognized. Among the pathogenic RNA variants are transcripts with single nucleotide substitutions, small insertions or deletions, aberrantly or alternatively spliced transcripts and RNAs derived from fused genes. To discriminate among transcripts, particularly those of low ab...
Source: Mutation Research Reviews in Mutation Research - September 14, 2016 Category: Genetics & Stem Cells Source Type: research

Beyond mouse cancer models: three-dimensional human-relevant in vitro and non-mammalian in vivo models for photodynamic therapy
Publication date: Available online 12 September 2016 Source:Mutation Research/Reviews in Mutation Research Author(s): Malgorzata Kucinska, Marek Murias, Patrycja Nowak-Sliwinska The proper design of experiments is a critical step for each study in order to obtain reproducible and reliable data. Taking into account constant competitiveness in the quickly developing biomedical sciences and the availability of sophisticated techniques, the choice and establishment of an experimental model system is essential for a successful research project. Currently, various sophisticated in vitro and in vivo models are being designed...
Source: Mutation Research Reviews in Mutation Research - September 12, 2016 Category: Genetics & Stem Cells Source Type: research

Insulin-like growth factor (IGF) axis in cancerogenesis
Publication date: Available online 4 September 2016 Source:Mutation Research/Reviews in Mutation Research Author(s): Aldona Kasprzak, Wojciech Kwasniewski, Agnieszka Adamek, Anna Gozdzicka-Jozefiak Determination of the role of insulin-like growth factor (IGF) family components in carcinogenesis of several human tumors is based on numerous epidemiological and pre-clinical studies, experiments in vivo and in vitro and on attempts at application of drugs affecting the IGF axis. Investigative hypotheses in original studies were based on biological functions manifested by the entire family of IGF (ligands, receptors, link...
Source: Mutation Research Reviews in Mutation Research - September 3, 2016 Category: Genetics & Stem Cells Source Type: research

Individual response to ionizing radiation
Publication date: Available online 4 September 2016 Source:Mutation Research/Reviews in Mutation Research Author(s): Nicolas Foray, Michel Bourguignon, Nobuyuki Hamada The human response to ionizing radiation (IR) varies among individuals. The first evidence of the individual response to IR was reported in the beginning of the 20th century. Considering nearly one century of observations, we here propose three aspects of individual IR response: radiosensitivity for early or late adverse tissue events after radiotherapy on normal tissues (non-cancer effects attributable to cell death); radiosusceptibility for IR-induced...
Source: Mutation Research Reviews in Mutation Research - September 3, 2016 Category: Genetics & Stem Cells Source Type: research

Potentiation of Hydrogen Peroxide Toxicity: From Catalase Inhibition to Stable DNA-iron Complexes
Publication date: Available online 30 August 2016 Source:Mutation Research/Reviews in Mutation Research Author(s): Tulip Mahaseth, Andrei Kuzminov Hydrogen peroxide (H2O2) is unique among general toxins, because it is stable in abiotic environments at ambient temperature and neutral pH, yet rapidly kills any type of cells by producing highly-reactive hydroxyl radicals. This life-specific reactivity follows distribution of soluble iron, Fe(II) (which combines with H2O2 to form the famous Fenton's reagent),—Fe(II) is concentrated inside cells, but is virtually absent outside them. Because of the immediate danger of H2O...
Source: Mutation Research Reviews in Mutation Research - August 30, 2016 Category: Genetics & Stem Cells Source Type: research

Cataractogenesis following high-LET radiation exposure
Publication date: Available online 20 August 2016 Source:Mutation Research/Reviews in Mutation Research Author(s): Nobuyuki Hamada, Tatsuhiko Sato Biological effectiveness of ionizing radiation differs with its linear energy transfer (LET) such that high-LET radiation is more effective for various biological endpoints than low-LET radiation. Human exposure to high-LET radiation occurs in cancer patients, nuclear workers, aviators, astronauts and other space travellers. From the radiation protection viewpoint, the ocular lens is among the most radiosensitive tissues in the body, and cataract (a clouding of the normally ...
Source: Mutation Research Reviews in Mutation Research - August 20, 2016 Category: Genetics & Stem Cells Source Type: research

Human epidermal stem cells: role in adverse skin reactions and carcinogenesis from radiation
Publication date: Available online 17 August 2016 Source:Mutation Research/Reviews in Mutation Research Author(s): Michèle T Martin, Adeline Vulin, Jolyon H Hendry In human skin, keratinopoiesis is based on a functional hierarchy among keratinocytes, with rare slow-cycling stem cells responsible for the long-term maintenance of the tissue through their self-renewal potential, and more differentiated daughter progenitor cells actively cycling to permit epidermal renewal and turn-over every month. Skin is a radio-responsive tissue, developing all types of radiation damage and pathologies, including early tissue reactio...
Source: Mutation Research Reviews in Mutation Research - August 17, 2016 Category: Genetics & Stem Cells Source Type: research

Exposure of ionizing radiation on the mammalian brain: Epidemiological evidence, pathological and molecular effects and prevention strategies
Publication date: Available online 13 August 2016 Source:Mutation Research/Reviews in Mutation Research Author(s): Daniela Hladik, Soile Tapio Epidemiological studies on the atomic-bomb survivors, cancer survivors and occupational cohorts provide strong evidence for multifaceted damage to brain after ionizing radiation. Radiation-induced late effects may manifest as brain tumors or cognitive impairment. Decreased neurogenesis and differentiation, alteration in neural structure and synaptic plasticity as well as increased oxidative stress and inflammation are suggested to contribute to adverse effects in the brain. In a...
Source: Mutation Research Reviews in Mutation Research - August 13, 2016 Category: Genetics & Stem Cells Source Type: research

Heinrich Valdemar Malling (1931 –2016)
Publication date: Available online 8 August 2016 Source:Mutation Research/Reviews in Mutation Research Author(s): Daniel A. Casciano, Jack B. Bishop, David M. DeMarini, Errol Zeiger, George R. Hoffmann (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - August 8, 2016 Category: Genetics & Stem Cells Source Type: research