Mutation Research Reviews in Mutation Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

From Sperm to Offspring: Assessing the Heritable Genetic Consequences of Paternal Smoking and Potential Public Health Impacts
The objective of this work was to review the scientific literature on the effects of paternal smoking on sperm and assess the consequences to offspring. A literature search identified over 200 studies with relevant data in humans and animal models. The available data were reviewed to assess the weight of evidence that tobacco smoke is a human germ cell mutagen and estimate effect sizes. These results were used to model the potential increase in genetic disease burden in offspring caused by paternal smoking, with specific focus on aneuploid syndromes and intellectual disability, and the socioeconomic impacts of such an effe...
Source: Mutation Research Reviews in Mutation Research - April 12, 2017 Category: Genetics & Stem Cells Source Type: research

Reflections on a Career and on the History of Genetic Toxicity Testing in the National Toxicology Program
Publication date: Available online 22 March 2017 Source:Mutation Research/Reviews in Mutation Research Author(s): Errol Zeiger One of the highly visible aspects of the U.S. National Toxicology Program (NTP) has been its genetic toxicity testing program, which has been responsible for testing, and making publicly available, in vitro and in vivo test data on thousands of chemicals since 1979. What is less well known, however, is that this NTP program had its origin in two separate testing programs that were initiated independently at the National Cancer Institute (NCI) and the National Institute of Environmental Health Sc...
Source: Mutation Research Reviews in Mutation Research - March 22, 2017 Category: Genetics & Stem Cells Source Type: research

Alpha-1-antitrypsin deficiency: Genetic variations, clinical manifestations and therapeutic interventions
Publication date: Available online 18 March 2017 Source:Mutation Research/Reviews in Mutation Research Author(s): Younis Mohammad Hazari, Arif Bashir, Mudasir Habib, Samirul Bashir, Huma Habib, M. Abul Qasim, Naveed Nazir Shah, Ehtishamul Haq, Jeffrey Teckmane, Khalid Majid Fazili Alpha-1-antitrypsin (AAT) is an acute phase secretory glycoprotein that inhibits neutrophil proteases like elastase and is considered as the archetype of a family of structurally related serine protease inhibitors termed serpins. Serum AAT predominantly originates from liver and increases three to five fold during host response to tis...
Source: Mutation Research Reviews in Mutation Research - March 18, 2017 Category: Genetics & Stem Cells Source Type: research

Targeting telomerase and telomeres to enhance ionizing radiation effects in in vitro and in vivo cancer models
Publication date: Available online 24 February 2017 Source:Mutation Research/Reviews in Mutation Research Author(s): F. Berardinelli, E. Coluzzi, A. Sgura, A. Antoccia One of the hallmarks of cancer consists in the ability of tumor cells to divide indefinitely, and to maintain stable telomere lengths throughout the activation of specific telomere maintenance mechanisms (TMM). Therefore in the last fifteen years, researchers proposed to target telomerase or telomeric structure in order to block limitless replicative potential of cancer cells providing a fascinating strategy for a broad-spectrum cancer therapy. In the ...
Source: Mutation Research Reviews in Mutation Research - February 24, 2017 Category: Genetics & Stem Cells Source Type: research

When the guardian sleeps: Reactivation of the p53 pathway in cancer
Publication date: Available online 17 February 2017 Source:Mutation Research/Reviews in Mutation Research Author(s): Olaf Merkel, Ninon Taylor, Nicole Prutsch, Philipp Staber, Richard Moriggl, Suzanne Turner, Lukas Kenner Half of all cancers carry loss of function mutations in the TP53 gene whereas in the other half, wild-type p53 protein is deactivated by other means. Hence, restoration of wild-type p53 function is of universal therapeutic importance for a multitude of cancers. In this review, we describe current therapeutic approaches targeting p53 and its two main antagonists MDM2 and MDM4, which lead to activa...
Source: Mutation Research Reviews in Mutation Research - February 16, 2017 Category: Genetics & Stem Cells Source Type: research

Repair of Oxidatively Induced DNA Damage by DNA Glycosylases: Mechanisms of Action, Substrate Specificities and Excision Kinetics
Publication date: Available online 16 February 2017 Source:Mutation Research/Reviews in Mutation Research Author(s): Miral Dizdaroglu, Erdem Coskun, Pawel Jaruga Endogenous and exogenous reactive species cause oxidatively induced DNA damage in living organisms by a variety of mechanisms. As a result, a plethora of mutagenic and/or cytotoxic products are formed in cellular DNA. This type of DNA damage is repaired by base excision repair, although nucleotide excision repair also plays a limited role. DNA glycosylases remove modified DNA bases from DNA by hydrolyzing the glycosidic bond leaving behind an apurinic/apyrimi...
Source: Mutation Research Reviews in Mutation Research - February 15, 2017 Category: Genetics & Stem Cells Source Type: research

Fate of micronuclei and micronucleated cells
Publication date: Available online 13 February 2017 Source:Mutation Research/Reviews in Mutation Research Author(s): Henning Hintzsche, Ulrike Hemmann, Albrecht Poth, Dietmar Utesch, Jasmin Lott, Helga Stopper The present review describes available evidence about the fate of micronuclei and micronucleated cells. Micronuclei are small, extranuclear chromatin bodies surrounded by a nuclear envelope. The mechanisms underlying the formation of micronuclei are well understood but not much is known about the potential fate of micronuclei and micronucleated cells. Many studies with different experimental approaches addres...
Source: Mutation Research Reviews in Mutation Research - February 12, 2017 Category: Genetics & Stem Cells Source Type: research

The IGF axis in HPV associated cancers
Publication date: Available online 4 February 2017 Source:Mutation Research/Reviews in Mutation Research Author(s): Adam Pickard, Julia Durzynska, Dennis J. McCance, Elisabeth R. Barton Human papillomaviruses (HPV) infect and replicate in stratified epithelium at cutaneous and mucosal surfaces. The proliferation and maintenance of keratinocytes, the cells which make up this epithelium, is controlled by a number of growth factor receptors such as the keratinocyte growth factor receptor (KGFR, also called fibroblast growth factor receptor 2b (FGFR2b)), the epithelial growth factor receptor (EGFR) and the insulin-like g...
Source: Mutation Research Reviews in Mutation Research - February 4, 2017 Category: Genetics & Stem Cells Source Type: research

Scientific Feuds, Polemics, and Ad Hominem Arguments in Basic and Special-Interest Genetics
This article reviews some of the history of ad hominem arguments in science and the background to the attacks by Calabrese. I argue that Calabrese’s characterization of Muller and his supporters is unjust, misleading, and hurtful. I also propose some methods for dealing with or preventing ad hominem attacks in professional journals. (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - February 3, 2017 Category: Genetics & Stem Cells Source Type: research

Ionizing radiation biomarkers in epidemiological studies – An update
Publication date: Available online 16 January 2017 Source:Mutation Research/Reviews in Mutation Research Author(s): Janet Hall, Penny A. Jeggo, Catharine West, Maria Gomolka, Roel Quintens, Christophe Badie, Olivier Laurent, An Aerts, Nataša Anastasov, Omid Azimzadeh, Tamara Azizova, Sarah Baatout, Bjorn Baselet, Rafi Benotmane, Eric Blanchardon, Yann Guéguen, Siamak Haghdoost, Mats Harms-Ringhdahl, Julia Hess, Michaela Kreuzer, Dominique Laurier, Ellina Macaeva, Grainne Manning, Eileen Pernot, Jean-Luc Ravanat, Laure Sabatier, Karine Tack, Soile Tapio, Horst Zitzelsberger, Elisabeth Cardi...
Source: Mutation Research Reviews in Mutation Research - January 16, 2017 Category: Genetics & Stem Cells Source Type: research

Contribution of genetic factors to platinum-based chemotherapy sensitivity and prognosis of non-small cell lung cancer
Publication date: Available online 23 November 2016 Source:Mutation Research/Reviews in Mutation Research Author(s): Cristina Pérez-Ramírez, Marisa Cañadas-Garre, Miguel Ángel Molina, Ana I. Robles, María José Faus-Dáder, Miguel Ángel Calleja-Hernández Although platinum-based chemotherapy remains the standard treatment for advanced NSCLC patients, clinical outcomes are poor and most patients develop high-grade toxicities. Genetic factors, such as single nucleotide polymorphisms (SNPs) involved in platinum pharmacodynamics, metabolism and mechanism of action, may account for inter-individual differences sho...
Source: Mutation Research Reviews in Mutation Research - November 23, 2016 Category: Genetics & Stem Cells Source Type: research

TERT promoter mutations in telomere biology
Publication date: Available online 23 November 2016 Source:Mutation Research/Reviews in Mutation Research Author(s): Barbara Heidenreich, Rajiv Kumar Telomere repeats at chromosomal ends, critical to genome integrity, are maintained through an elaborate network of proteins and pathways. Shelterin complex proteins shield telomeres from induction of DNA damage response to overcome end protection problem. A specialized ribonucleic protein, telomerase, maintains telomere homeostasis through repeat addition to counter intrinsic shortcomings of DNA replication that leads to gradual sequence shortening in successive mitoses. ...
Source: Mutation Research Reviews in Mutation Research - November 23, 2016 Category: Genetics & Stem Cells Source Type: research

Reprint of “Biomonitoring of genotoxic effects for human exposure to nanomaterials: The challenge ahead”
Publication date: Available online 16 November 2016 Source:Mutation Research/Reviews in Mutation Research Author(s): Laetitia Gonzalez, Micheline Kirsch-Volders Exposures to nanomaterials (NMs), with their specific physico-chemical characteristics, are likely to increase over the next years, as their production for industrial, consumer and medical applications is steadily rising. Therefore, there is an urgent need for the implementation of human biomonitoring studies of genotoxic effects after NM exposures in order to monitor and assure safety for workers and the general population. In this review, most commonly used b...
Source: Mutation Research Reviews in Mutation Research - November 16, 2016 Category: Genetics & Stem Cells Source Type: research

A systematic review and meta-analysis of the association between long non-coding RNA polymorphisms and cancer risk
Publication date: Available online 5 November 2016 Source:Mutation Research/Reviews in Mutation Research Author(s): Zhi Lv, Qian Xu, Yuan Yuan It has been suggested that long non-coding RNA (lncRNA) gene polymorphisms are associated with cancer risk. In this article, we conducted a systematic review related to studies on the association between lncRNA single-nucleotide polymorphisms (SNPs) and the overall risk of cancer. A total 17 SNPs in four common lncRNA genes were included in the meta-analysis. In the lncRNA H19, the rs2735971A/G, rs2839698C/T, and rs3024270G/C polymorphisms, but not rs217727C/T, were correlated ...
Source: Mutation Research Reviews in Mutation Research - November 5, 2016 Category: Genetics & Stem Cells Source Type: research

An insight into the genotoxicity assessment studies in dipterans
Publication date: Available online 13 October 2016 Source:Mutation Research/Reviews in Mutation Research Author(s): Nidhi Mishra, Rashmi Srivastava, Uma Rani Agrawal, Raghav Ram Tewari The dipterans have been widely utilized in genotoxicity assessment studies. Short life span, easy maintenance, production of large number of offspring in a single generation and the tissues with appropriate cell populations make these flies ideal for studies associated to developmental biology, diseases, genetics, genetic toxicology and stress biology in the group. Moreover, their cosmopolitan presence makes them suitable candidate for...
Source: Mutation Research Reviews in Mutation Research - October 14, 2016 Category: Genetics & Stem Cells Source Type: research