Mutation Research Reviews in Mutation Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Dietary mycotoxins, co-exposure, and carcinogenesis in humans: Short review
Publication date: Available online 5 August 2015 Source:Mutation Research/Reviews in Mutation Research Author(s): Karl De Ruyck, Marthe De Boevre, Inge Huybrechts, Sarah De Saeger Mycotoxins, toxic secondary metabolites of fungi, affect global agriculture so prolifically that they are virtually ubiquitous at some concentration in the average human diet. Studies of in vitro and in vivo toxicity are discussed, leading to investigations of co-exposed mycotoxins, as well as carcinogenic effects. Some of the most common and toxicologically significant mycotoxins, such as the aflatoxins, ochratoxins, fumonisins, deox...
Source: Mutation Research Reviews in Mutation Research - August 16, 2015 Category: Genetics & Stem Cells Source Type: research

Clinical application of micronucleus test in exfoliated buccal cells: a systematic review and metanalysis
Publication date: Available online 5 August 2015 Source:Mutation Research/Reviews in Mutation Research Author(s): Claudia Bolognesi, Stefano Bonassi, Siegfried Knasmueller, Michael Fenech, Marco Bruzzone, Cecilia Lando, Marcello Ceppi The micronucleus assay in uncultured exfoliated buccal mucosa cells, involving minimally invasive sampling, was successfully applied to evaluate inhalation and local exposure to genotoxic agents, impact of nutrition and lifestyle factors. The potential use of the assay in clinics to monitor the development of local oral lesions and as an early biomarker for tumors and differ...
Source: Mutation Research Reviews in Mutation Research - August 7, 2015 Category: Genetics & Stem Cells Source Type: research

Dietary mycotoxins, co-exposure, and carcinogenesis in humans: short review.
Publication date: Available online 5 August 2015 Source:Mutation Research/Reviews in Mutation Research Author(s): Karl De Ruyck, Marthe De Boevre, Inge Huybrechts, Sarah De Saeger Mycotoxins, toxic secondary metabolites of fungi, affect global agriculture so prolifically that they are virtually ubiquitous at some concentration in the average human diet. Studies of in vitro and in vivo toxicity are discussed, leading to investigations of co-exposed mycotoxins, as well as carcinogenic effects. Some of the most common and toxicologically significant mycotoxins, such as the aflatoxins, ochratoxins, fumonisins, deox...
Source: Mutation Research Reviews in Mutation Research - August 7, 2015 Category: Genetics & Stem Cells Source Type: research

Genetic mutations strengthen functional association of LAP1 with DYT1 dystonia and muscular dystrophy
Publication date: Available online 5 August 2015 Source:Mutation Research/Reviews in Mutation Research Author(s): Sandra Rebelo, Edgar F. da Cruz e Silva, Odete A.B. da Cruz e Silva Lamina-associated polypeptide 1 (LAP1) is a ubiquitously expressed integral protein of the inner nuclear membrane. It interacts physically with lamins, torsinA, emerin and protein phosphatase 1; potentially providing a pivotal mechanism for transducing signals across the inner nuclear membrane. In neurons a functional protein complex is formed, comprising LAP1 and torsinA and in skeletal muscle LAP1 and emerin likewise form a protein ...
Source: Mutation Research Reviews in Mutation Research - August 7, 2015 Category: Genetics & Stem Cells Source Type: research

Persistent γH2AX: a promising molecular marker of DNA damage and aging
Publication date: Available online 21 July 2015 Source:Mutation Research/Reviews in Mutation Research Author(s): Mohammad Sabbir Siddiqui, Maxime François, Michael F. Fenech, Wayne R. Leifert One of the earliest cellular responses to DNA double strand breaks (DSBs) is the phosphorylation of the core histone protein H2AX (termed γH2AX). Persistent γH2AX is the level of γH2AX above baseline, measured at a given time-point beyond which DNA DSBs are normally expected to be repaired (usually persist for days to months). This review summarises the concept of persistent γH2AX in the context of exogenous source in...
Source: Mutation Research Reviews in Mutation Research - July 21, 2015 Category: Genetics & Stem Cells Source Type: research