The YPEL5-PPP1CB fusion transcript is detected in different hematological malignancies and in normal samples
Publication date: Available online 6 August 2015 Source:Leukemia Research Reports Author(s): Karl Vandepoele, Jan Philippé, Barbara Denys Chronic lymphocytic leukemia (CLL) is the most frequent leukemia in Western adults. It was suggested that transcripts from a reciprocal trans-splicing event between YPEL5 and PPP1CB were present exclusively in CLL patients (more than 90%). Here we show that the YPEL5-PPP1CB fusion is not specific for CLL but is also detected in other hematological malignancies such as chronic myeloid leukemia, monoclonal B cell lymphocytosis or acute leukemia and also in normal samples. As suc...
Source: Leukemia Research Reports - August 7, 2015 Category: Hematology Source Type: research
Pseudo-Guillain–Barré syndrome masking acute myeloid leukemia relapse: Brief report and review
Publication date: 2015 Source:Leukemia Research Reports, Volume 4, Issue 2 Author(s): Fadi El Karak, Elie El Rassy, Samer Tabchi, Eliane Chouery, Andre Megarbane, Joseph Kattan Central nervous system (CNS) relapse is not a rare presentation in acute myeloid leukemia (AML) as its incidence ranges between 2% and 9%. It manifests with meningeal leukemia, cranial nerve palsies or cerebral mesenchymal myeloid sarcoma. We herein report the case of a 69 year-old female that presented a pseudo-Guillain–Barré syndrome masking an AML CNS relapse. Her symptoms completely resolved upon administration of a tailored t...
Source: Leukemia Research Reports - July 26, 2015 Category: Hematology Source Type: research
Associations between genetic variants in folate and drug metabolizing pathways and relapse risk in pediatric acute lymphoid leukemia on CCG-1952
Publication date: Available online 21 July 2015 Source:Leukemia Research Reports Author(s): Marijana Vujkovic, Aaron Kershenbaum, Lisa Wray, Thomas McWilliams, Shannon Cannon, Meenakshi Devidas, Linda Stork, Richard Aplenc Genetic variation in drug detoxification pathways may influence outcomes in pediatric acute lymphoblastic leukemia (ALL). We evaluated relapse risk and 24 variants in 15 genes in 714 patients in CCG-1961. Three TPMT and 1 MTR variant were associated with increased risks of relapse (rs4712327, OR 3.3, 95%CI 1.2–8.6; rs2842947, OR 2.7, 95%CI 1.1–6.8; rs2842935, OR 2.5, 95%CI 1.1–5...
Source: Leukemia Research Reports - July 22, 2015 Category: Hematology Source Type: research
Pseudo-Guillain-Barré syndrome masking acute myeloid leukemia relapse: Brief report and review
Publication date: Available online 17 July 2015 Source:Leukemia Research Reports Author(s): Fadi El Karak, Elie El Rassy, Samer Tabchi, Eliane Chouery, Andre Megarbane, Joseph Kattan Central nervous system (CNS) relapse is not a rare presentation in acute myeloid leukemia (AML) as its incidence ranges between 2-9%. It manifests with meningeal leukemia, cranial nerve palsies or cerebral mesenchymal myeloid sarcoma. We herein report the case of a 69 year-old female that presented a pseudo-Guillain-Barré syndrome masking an AML CNS relapse. Her symptoms completely resolved upon administration of a tailored tr...
Source: Leukemia Research Reports - July 18, 2015 Category: Hematology Source Type: research
Chronic-phase chronic myeloid leukemia: Not always a reassuring diagnosis
We report the challenging case of a CML patient who was resistant to multiple TKIs because of different emerging ABL mutations and became pregnant while on Nilotinib therapy despite repeated and clear discouragement to conceive. She decided to continue with her pregnancy, showing an admirable and incredible perseverance in the pursuit of her personal aims. (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - July 18, 2015 Category: Hematology Source Type: research
Acute acalculous cholecystitis complicating chemotherapy for acute myeloblastic leukemia
We present two acute myeloblastic leukemia patients that developed acute acalculous cholecystitis during chemotherapy-induced neutropenia. They suffered from fever, vomiting and acute pain in the epigastrium. Ultrasound demonstrated an acalculous gallbladder. Surgical management was required in one patient and conservative treatment was attempted in the other patient. None treatment measures were effective and two patients died. Acute acalculous cholecystitis is a serious complication in neutropenic patients. Earlier diagnosis could have expedited the management of these patients. (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - July 18, 2015 Category: Hematology Source Type: research
Unusual massive bone marrow fibrosis in acute promyelocytic leukemia following arsenic trioxide therapy
Publication date: Available online 15 July 2015 Source:Leukemia Research Reports Author(s): S Venkatesan, Abhishek Purohit, Ankur Ahuja, Dinesh Chandra, Mukul Aggarwal, R Amrita, Ravi Kumar, Manoranjan Mahapatra, Hara P Pati, Seema Tyagi Bone marrow fibrosis has been associated with different types of non-neoplastic conditions like granulomatous and autoimmune diseases and a variety of neoplastic disorders such as acute megakaryoblastic leukemia, Hodgkin Lymphoma, Non-Hodgkin Lymphoma and myeloproliferative neoplsms. Therapy induced fibrosis is a rare phenomenon. Here we report a case of an incident...
Source: Leukemia Research Reports - July 17, 2015 Category: Hematology Source Type: research
Successful pregnancy outcome in paroxysmal nocturnal hemoglobinuria (PNH) following escalated eculizumab dosing to control breakthrough hemolysis
We describe a case of a 30 year old female with hypoplastic myelodysplastic syndrome and PNH. After two years of treatment with eculizumab, she became pregnant. She developed breakthrough hemolysis at 20 weeks gestation. Pharmacokinetic and pharmacodynamic studies demonstrated a subtherapeutic eculizumab level with absence of complement blockade. Escalation of her eculizumab dose successfully controlled hemolysis and restored therapeutic eculizumab level and activity. She delivered a healthy baby at 36 weeks. Graphical abstract (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - May 17, 2015 Category: Hematology Source Type: research
Corrigendum to “Combination therapy with interferon and JAK1-2 inhibitor is feasible. Proof of concept with rapid reduction in JAK2V617F-allele burden in Polycythemia Vera” [Leuk. Res. Rep. 3 (2) (2014) 73–75]
Publication date: 2015 Source:Leukemia Research Reports, Volume 4, Issue 1 Author(s): M.E. Bjørn , K. de Stricker , L. Kjær , K. Ellemann , H.C. Hasselbalch (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - May 16, 2015 Category: Hematology Source Type: research
Acute Myeloid Leukemia in a Patient with Constitutional 47,XXY Karyotype
We present a case of a 54-year-old male diagnosed with acute myeloid leukemia (AML) with monocytic differentiation, whose cytogenetic and subsequent FISH analyses revealed a constitutional 47,XXY karyotype. We also review and discuss relevant prior literature. (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - April 23, 2015 Category: Hematology Source Type: research
Linking the SUMO protease SENP5 to neutrophil differentiation of AML cells
Publication date: Available online 23 April 2015 Source:Leukemia Research Reports Author(s): Elena A. Federzoni , Severin Gloor , Jing Jin , Deborah Shan , Martin F. Fey , Bruce E. Torbett , Mario P. Tschan In an mRNA profiling screen performed to unveil novel mechanisms of leukemogenesis, we found that the sentrin-specific protease 5 (SENP5) was significantly repressed in clinical acute myeloid leukemia when compared to healthy neutrophil samples. SENP5 is an enzyme that targets and cleaves small ubiquitin-like modifier (SUMO) residues from SUMOylated proteins. Further investigation with AML neutrophil differen...
Source: Leukemia Research Reports - April 23, 2015 Category: Hematology Source Type: research
Two novel RUNX1 Mutations in a patient with congenital thrombocytopenia that evolved into a High grade myelodysplastic syndrome
Publication date: Available online 3 April 2015 Source:Leukemia Research Reports Author(s): Jessica M. Schmit , Daniel J. Turner , Robert A. Hromas , John R. Wingard , Randy A. Brown , Ying Li , Marilyn M. Li , William B. Slayton , Christopher R. Cogle Here we report two new RUNX1 mutations in one patient with congenital thrombocytopenia that transformed into a high grade myelodysplastic syndrome with myelomonocytic features. The first mutation, c.837G>A, was a nucleotide base substitution from guanine to adenine within exon 8, resulting in a nonsense mutation of amino acid tryptophan (W) to a premature...
Source: Leukemia Research Reports - April 3, 2015 Category: Hematology Source Type: research
Acute appendicitis in acute leukemia and the potential role of decitabine in the critically ill patient
We present our experience with acute appendicitis in children with acute leukemia and a case of complete remission of acute myeloid leukemia with a short course of decitabine. Decitabine may serve as bridging therapy in critically ill patients who are unable to undergo intensive chemotherapy. (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - March 19, 2015 Category: Hematology Source Type: research
An intensive approach to treatment for older patients with relapsed isolated NPM1 mutated AML
Publication date: Available online 16 January 2015 Source:Leukemia Research Reports Author(s): Srivasavi Dukka , David T Bowen (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - January 17, 2015 Category: Hematology Source Type: research
Effects of 5-azacytidine on natural killer cell activating receptor expression in patients with refractory anemia with excess of blasts
In this study we investigated the effect of the demethylating drug 5-azacytidine (Vidaza®) on NK receptors with the hypothesis that demethylation of the promoters of activating NK receptor genes induces gene reactivation and thus may increase their expression. (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - January 16, 2015 Category: Hematology Source Type: research
