The YPEL5-PPP1CB fusion transcript is detected in different hematological malignancies and in normal samples

Publication date: Available online 6 August 2015 Source:Leukemia Research Reports Author(s): Karl Vandepoele, Jan Philippé, Barbara Denys Chronic lymphocytic leukemia (CLL) is the most frequent leukemia in Western adults. It was suggested that transcripts from a reciprocal trans-splicing event between YPEL5 and PPP1CB were present exclusively in CLL patients (more than 90%). Here we show that the YPEL5-PPP1CB fusion is not specific for CLL but is also detected in other hematological malignancies such as chronic myeloid leukemia, monoclonal B cell lymphocytosis or acute leukemia and also in normal samples. As such, it is unlikely that the YPEL5-PPP1CB fusion is a good drug target in CLL or a suitable target to monitor disease.
Source: Leukemia Research Reports - Category: Hematology Source Type: research