Copy Number Aberrations in B-Cell Lymphoma: A Call for Consideration in Prognosis Determination and Therapy
Publication date: Available online 22 April 2019Source: Leukemia Research ReportsAuthor(s): Elizabeth Kertowidjojo, Kristin Sticco, Tahmeena Ahmed, Yupo Ma, Ann-Leslie Berger-Zaslav (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - April 23, 2019 Category: Hematology Source Type: research
Effective maintenance treatment with lenalidomide for a patient with aggressive adult T cell leukemia after chemotherapy
Publication date: Available online 13 April 2019Source: Leukemia Research ReportsAuthor(s): Satoko Oka, Kazuo Ono, Masaharu NohgawaAbstractAdult T cell leukemia/lymphoma (ATL) is incurable with conventional chemotherapies, and allogeneic stem cell transplantation (SCT) is the only curative treatment. Direct antitumor effects and antitumor immune responses are important factors that need to be considered in the treatment of ATL. A phase II study reported long overall survival despite short progression-free survival in patients, implying that lenalidomide confers a survival benefit through immunomodulation for patients with ...
Source: Leukemia Research Reports - April 14, 2019 Category: Hematology Source Type: research
Clonal evolution revealed by next-generation sequencing in a long-term follow-up patient with hypereosinophilia
Publication date: Available online 8 April 2019Source: Leukemia Research ReportsAuthor(s): Meiyu Chen, Jie Liu, Wei Qin, Qian Wang, Ri Zhang, Hongying ChaoAbstractThe natural history of primary hypereosinophilia remains poorly defined, given the underlying disease heterogeneity. Recently, targeted NGS helps to establish clonality in a subset of patients with hypereosinophilia. We first reported the clonal evolution in a long-term follow-up patient with hypereosinophilia. This case initially presented with chronic eosinophilic leukemia, not otherwise specified (CEL-NOS), successively transformed to myelodysplastic syndromes...
Source: Leukemia Research Reports - April 9, 2019 Category: Hematology Source Type: research
Chronic myelomonocytic leukemia as a transformation from polycythemia vera
We present a case of PV that progressed to CMML. We demonstrated the CMML clone was most likely derived from PV- JAK2V617F clone, and carried a complex genetic mutations of ASXL1, RUNX1, SRSF2 and TET2, NRAS, KRAS, plus CMML cells were of the classical phenotype CD14+ CD16− by flow cytometry. (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - March 15, 2019 Category: Hematology Source Type: research
Matched unrelated donor hematopoietic progenitor cell transplantation: A report based on a single registry in India
ConclusionsThe patient DFS data prove that even a small registry with slightly more than 7,000 donors can yield reasonable patient outcomes. (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - March 13, 2019 Category: Hematology Source Type: research
Myodesopsia is a symptom of central nervous system blast crisis in chronic myeloid leukemia
Publication date: Available online 5 March 2019Source: Leukemia Research ReportsAuthor(s): Kazuyoshi Ishii, Aya Nakaya, Shinya Fujita, Atsushi Satake, Yoshiko Azuma, Yukie Tsubokura, Ryo Saito, Akiko Konishi, Masaaki Hotta, Hideaki Yoshimura, Tomoki Ito, Shosaku NomuraAbstractA 49-year-old woman diagnosed with chronic myeloid leukemia in the chronic phase was started on dasatinib treatment, after which she complained of myodesopsia. Nineteen months after diagnosis, the patient again complained of myodesopsia and developed bilateral optic neuritis. Cerebrospinal fluid analysis revealed an increase in blasts, although periph...
Source: Leukemia Research Reports - March 6, 2019 Category: Hematology Source Type: research
Evaluation of eltrombopag in patients with aplastic anemia in real-world experience
Conclusion: Eltrombopag is a promising agent for treating patients with any degree of AA. (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - March 6, 2019 Category: Hematology Source Type: research
Cytomegalovirus reactivation triggers the late onset of hyperthyroidism after autologous peripheral blood transplantation
Publication date: Available online 22 November 2018Source: Leukemia Research ReportsAuthor(s): Satoko Oka, Kazuo Ono, Masaharu NohgawaAbstractThyroid dysfunction is an important issue in patients receiving autologous and allogenic hematopoietic stem cell transplantation (HSCT). However, the exact mechanisms underlying thyrotoxicosis secondary to HSCT remain unclear. The present case exhibited a reversed imbalance in helper/suppressor T-cell populations and B-cell dysregulation for a long time after transplantation, and the reactivation of cytomegalovirus may have been associated with the development of clinical hyperthyroi...
Source: Leukemia Research Reports - November 23, 2018 Category: Hematology Source Type: research
The rare translocation t(14;21)(q11;q22) detected in a Moroccan patient with T-cell acute lymphoblastic leukemia
Publication date: Available online 22 November 2018Source: Leukemia Research ReportsAuthor(s): Z. Takki Chebihi, A. Belkhayat, E. Chadli, L. Hessissen, M. El Khorassani, M. El Kababri, A. Kili, M. Khattab, Y. Bakri, N. DakkaAbstractCytogenetic studies of acute lymphoblastic leukemia have been at the forefront of research in the pathogenesis of cancer. The presence of recurring chromosomal abnormalities (either numeral or structural rearrangements) provides immediate clues to the genetic events leading to leukemia and many abnormalities have important prognostic significance. The rare translocation t(14,21)(q11.2;q22) has b...
Source: Leukemia Research Reports - November 23, 2018 Category: Hematology Source Type: research
Potentially important miRNAs in Enteropathy-Associated T-cell lymphoma Pathogenesis: a pilot study
Publication date: Available online 16 October 2018Source: Leukemia Research ReportsAuthor(s): Lindsey Clarke, Raju SR Adduri, Paul Smyth, Fiona Quinn, Michael Jeffers, Barbara Dunne, John O'Leary, Susan McKiernan, Elisabeth Vandenberghe, Saumyadipta Pyne, Murali Dharan Bashyam, Orla Sheils, Richard Flavin (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - October 16, 2018 Category: Hematology Source Type: research
High-dose Methotrexate vs. Capizzi Methotrexate for the Treatment of Childhood T-cell Acute Lymphoblastic Leukemia
Publication date: Available online 9 October 2018Source: Leukemia Research ReportsAuthor(s): Wasil JastaniahAbstractSixty-three children (1 – 14 years of age) newly diagnosed with T-cell acute lymphoblastic leukemia were treated from January 2001 to December 2014. Patient outcomes were evaluated based on the regimen received; Capizzi methotrexate (C-MTX) vs. high-dose methotrexate (HDMTX). Complete remission (CR) was achieved in 54 of 60 (90.0%) patients and 3 patients died during induction. The 5-year overall survival (OS) and disease-free survival (DFS) were 88.3±6.5% and 85±7.5%, respectively. Post-induction, 35 pat...
Source: Leukemia Research Reports - October 9, 2018 Category: Hematology Source Type: research
Renal infiltration presenting as acute kidney injury in Hodgkin Lymphoma – a case report and review of the literature
Publication date: Available online 29 August 2018Source: Leukemia Research ReportsAuthor(s): Wellington Fernandes da Silva Junior, Laila Lopes de Farias Pinho, Cássio Lins Gil de Farias, Verônica Torres, Elerson Carlos Costalonga, George Coura Filho, Leonardo de Abreu Testagrossa, Vanderson Rocha, Valeria BuccheriAbstractRenal involvement in Hodgkin lymphoma (HL) is rare, although extralymphatic disease is usually found. Acute kidney injury is a recognized presentation of non-Hodgkin lymphoma, with bilateral kidney involvement, promptly requiring specific treatment. Regarding to HL, this manifestation is extremely rare a...
Source: Leukemia Research Reports - August 30, 2018 Category: Hematology Source Type: research
Lenalidomide induced durable remission in a patient with MDS/MPN-with ring sideroblasts and thrombocytosis with associated 5q- syndrome.
We describe a patient with MDS/MPN with ring sideroblasts and thrombocytosis who had deletions of long arm of chromosome 5 (5q-) and chromosome 20 (20q-). Molecular studies showed an exon 9, frame shift mutation in the calreticulin (CALR) gene, and absence of mutations in JAK2, MPL, SETBP1 or SF3B1.Treatment with lenalidomide resulted in durable clinical remission which has lasted 2 years. (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - August 24, 2018 Category: Hematology Source Type: research
All-Trans-Retinoic-Acid and Arsenic Trioxide Induced Remission in Promyelocytic Blast Crisis
Publication date: Available online 25 July 2018Source: Leukemia Research ReportsAuthor(s): Teresa A. Colvin, Pankit Vachhani, Sheila Sait, Vishala Neppalli, Eunice S. WangAbstractA 78-year-old-male with chronic myeloid leukemia (CML) treated for seven years with dasatinib developed an acute promyelocytic leukemia complicated by disseminated intravascular coagulopathy. A promyelocytic blast crisis was diagnosed by demonstrating co-expression of chimeric BCL/ABL and PML/RARα translocations by karyotyping, fluorescence in situ hybridization, and quantitative real-time polymerase chain reaction. Promyelocytic blast crisis of ...
Source: Leukemia Research Reports - July 25, 2018 Category: Hematology Source Type: research
Detection of KIT mutations in Core Binding Factor acute myeloid leukemia
Publication date: Available online 21 July 2018Source: Leukemia Research ReportsAuthor(s): Passant Badr, Ghada M Elsayed, Dalia Negm Eldin, Bahia Y Riad, Hamdy NayeraAbstractWe have investigated the frequency and the effect of KIT mutations on the outcome of patients with CBF-AML. 69 patients (35 pediatrics and 34 adults) with CBF-AML were enrolled in the study. The frequency of KIT mutations was higher in adults compared to pediatrics (22.9% and 14.7%, p=0.38) respectively. Leukocytosis ≥20 × 109 /L was significantly associated with pediatrics compared to adults. t(8;21)(q22;22) was significantly associated with th...
Source: Leukemia Research Reports - July 22, 2018 Category: Hematology Source Type: research
