Subcutaneous rituximab given to patients for other indications than CD20+ B-cell lymphoma: A monocentric study of 20 cases
Publication date: 2018Source: Leukemia Research Reports, Volume 9Author(s): Pierre Peterlin, Thierry Guillaume, Alice Garnier, Amandine Le Bourgeois, Beatrice Mahé, Viviane Dubruille, Nicolas Blin, Pierre Gallas, Cyrille Touzeau, Thomas Gastinne, Anne Lok, Patrick Thomare, Cecile Chauvin, Steven Le Gouill, Philippe Moreau, Patrice Chevallier (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - July 5, 2018 Category: Hematology Source Type: research
Unrelated HLA mismatched microtransplantation in a patient with refractory secondary acute myeloid leukemia
We describe the first reported patient with refractory AML who underwent salvage MST from an unrelated, complete HLA-mismatched donor. The patient achieved remission without complication, warranting further study of unrelated HLA-mismatched donor MST in AML. (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - July 5, 2018 Category: Hematology Source Type: research
Rituximab monotherapy become an optimal treatment for primary pulmonary malt lymphoma
Publication date: 2018Source: Leukemia Research Reports, Volume 9Author(s): A.I. Alvarez-Sánchez, C. Martínez-Losada (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - July 5, 2018 Category: Hematology Source Type: research
A rare case of a minimally secretory plasma cell leukemia with a hemorrhagic gastric plasmacytoma
Publication date: 2018Source: Leukemia Research Reports, Volume 9Author(s): Akshjot Puri, Michelle W. Lau, Xianfeng F. Zhao, Keith C. Chan, Kimberly Bader (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - July 5, 2018 Category: Hematology Source Type: research
Forskolin attenuates doxorubicin-induced accumulation of asymmetric dimethylarginine and s-adenosylhomocysteine via methyltransferase activity in leukemic monocytes
Publication date: 2018Source: Leukemia Research Reports, Volume 9Author(s): Sandhiya Ramachandran, Swetha Loganathan, Vinnie Cheeran, Soniya Charles, Ganesh Munuswamy-Ramanujan, Mohankumar Ramasamy, Vijay Raj, Kanchana MalaAbstractDoxorubicin (DOX) is an antitumor drug, associated with cardiomyopathy. Strategies to address DOX-cardiomyopathy are scarce. Here, we identify the effect of forskolin (FSK) on DOX-induced-asymmetric-dimethylarginine (ADMA) accumulation in monocytoid cells. DOX-challenge led to i) augmented cytotoxicity, reactive-oxygen-species (ROS) production and methyltransferase-enzyme-activity identified as A...
Source: Leukemia Research Reports - July 5, 2018 Category: Hematology Source Type: research
Acute promyelocytic leukemia presenting with features of metastatic osseous disease
We report an unusual case of APL in a 59 year old female without peripheral blood abnormalities or diffuse marrow involvement. Clinical and radiographic findings were initially interpreted as metastatic osseous disease but ultimately found to be APL. (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - July 5, 2018 Category: Hematology Source Type: research
1,25-OH2 vitamin D3 and AKT-inhibition increase glucocorticoid induced apoptosis in a model of T-cell acute lymphoblastic leukemia (ALL)
Publication date: 2018Source: Leukemia Research Reports, Volume 9Author(s): Maximilian Pistor, Lisa Schrewe, Steffen Haupeltshofer, Andrei Miclea, Simon Faissner, Andrew Chan, Robert HoepnerAbstractIn acute lymphoblastic leukemia (ALL), steroid resistance and hypovitaminosis D are both associated with a poor prognosis. We show that methylprednisolone, calcitriol and the AKT-inhibitor MK-2206 have a synergistic effect on the apoptosis of steroid resistant T-ALL cells. Compared to methylprednisolone monotherapy, calcitriol increases methylprednisolone induced apoptosis dose-dependently (1.37–1.92-fold; p < 0.05). P...
Source: Leukemia Research Reports - July 5, 2018 Category: Hematology Source Type: research
Anti-CD19 chimeric antigen receptor targeting of CD19 + acute myeloid leukemia
Publication date: 2018Source: Leukemia Research Reports, Volume 9Author(s): Gina Ma, Yi Wang, Tahmeena Ahmed, Ann-Leslie Zaslav, Laura Hogan, Cecilia Avila, Masayuki Wada, Huda SalmanAbstractAberrant expression of CD19 in acute myeloid leukemia (AML) is commonly associated with t(8;21)(q22;q22), although AML cases lacking this translocation occasionally express CD19. Mixed-phenotype acute leukemia also frequently expresses CD19. Chimeric antigen receptor (CAR) technology is a major breakthrough for cancer treatment, with the recent approval of CD19-directed CAR (CD19CAR) for treating B-cell malignancies. However, little in...
Source: Leukemia Research Reports - July 5, 2018 Category: Hematology Source Type: research
A case of chronic eosinophilic leukemia with secondary transformation to acute myeloid leukemia
We describe a case of CEL-NOS with two hierarchically related non-specific cytogenetic rearrangements, associated with an NPM1 mutation and followed by evolution to secondary AML. NPM1 mutations are not previously described in CEL-NOS. (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - July 5, 2018 Category: Hematology Source Type: research
The fear of lymphadenopathy: A cautionary case of sarcoidosis masquerading as recurrent diffuse large b-cell lymphoma (DLBCL)
We describe the cautionary case of a patient with advanced-stage large B-cell lymphoma (DLBCL). After combination chemotherapy, CT-PET revealed a persistent focus of likely DLBCL for which he received radiotherapy. Follow-up CT-PET showed diffuse hypermetabolic adenopathy and recurrent DLBCL was presumed. As part of clinical trial assessment, multiple biopsies showed non-caseating lymphadenitis consistent with sarcoidosis. No treatment for asymptomatic sarcoidosis was required and 18 months later he remains cancer-free. The presentation of sarcoidosis masquerading as recurrent DLBCL highlights the importance of tissue samp...
Source: Leukemia Research Reports - July 5, 2018 Category: Hematology Source Type: research
Delayed diagnosis of Shwachman diamond syndrome with short telomeres and a review of cases in Asia
We report a case of delayed diagnosis of SDS in a family with another child with aplastic anemia, and review reported cases of SDS in Asia. This highlights the gap in identifying inherited bone marrow failure syndromes in adults with hematologic malignancies. (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - July 5, 2018 Category: Hematology Source Type: research
Corrigendum to “Ibrutinib as a bridge to transplant in high-risk chronic lymphocytic leukemia: A case report and review of the literature” [Leukemia Res. Rep. 8 (2017) 21–23]
Publication date: Available online 19 March 2018Source: Leukemia Research ReportsAuthor(s): Annalisa Arcari, Simona Bassi, Lara Pochintesta, Elena Trabacchi, Carlo Filippo Moroni, Angela Rossi, Luca Zanlari, Daniele Vallisa (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - July 5, 2018 Category: Hematology Source Type: research
Effects of nilotinib on platelet function in patients with chronic myeloid leukemia in chronic phase
ConclusionNilotinib had no adverse effect on platelet function nor patients clotting tests. (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - July 5, 2018 Category: Hematology Source Type: research
Clinical characteristics and treatment outcome of patients with isochromosome 17q (i17q) abnormality and myeloid neoplasms: A single center experience
Publication date: Available online 20 June 2018Source: Leukemia Research ReportsAuthor(s): Siddhartha Ganguly, Mason Uvodich, Ajoy Dias, Joseph P. McGuirk (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - July 5, 2018 Category: Hematology Source Type: research
Tumor necrosis factor- and interleukin-6-producing high-grade B-cell lymphoma, not otherwise specified in the pleura
Publication date: Available online 28 June 2018Source: Leukemia Research ReportsAuthor(s): Shoko Nakayama, Mitsuhiro Matsuda, Tatsuya Adachi, Sanae Sueda, Kayo Ueda, Kunimitsu Kawahara, Yuka Ohashi, Sumie Awaji, Shigeo Hashimoto, Itaru MatsumuraAbstractA 65-year-old man was admitted to our hospital with left-sided chest and back pain and dyspnea. Computed tomography demonstrated a marked circumferential left pleural thickening. A thoracoscopic pleural biopsy led to a diagnosis of high-grade B-cell lymphoma, not otherwise specified (HGBL, NOS). Lymphoma cells were positive for tumor necrosis factor (TNF) and interleukin-6. ...
Source: Leukemia Research Reports - July 5, 2018 Category: Hematology Source Type: research
