Tumor Lysis Syndrome (TLS) following intrathecal chemotherapy in a child with acute myelogenous leukemia (AML)
Publication date: 2017Source: Leukemia Research Reports, Volume 8Author(s): Chana L. GlasserAbstractTumor Lysis Syndrome (TLS) is a well-known complication of induction therapy for hematologic malignancies. It is characterized by rapid breakdown of malignant white blood cells (WBCs) leading to metabolic derangements and serious morbidity if left untreated. Most commonly, TLS is triggered by systemic chemotherapy, however, there have been case reports of TLS following intrathecal (IT) chemotherapy, all in patients with acute lymphoblastic leukemia (ALL)/lymphoma. Here, we report the first case of a patient with acute myelog...
Source: Leukemia Research Reports - July 5, 2018 Category: Hematology Source Type: research
Thinking about CNS metastasis in cutaneous lymphoma: Analysis of existing data
Publication date: 2017Source: Leukemia Research Reports, Volume 8Author(s): Yi Yang, Heather WicklessAbstractTo determine some of the key clinical features that help prompt clinicians to pursue additional work-up for evaluation of CNS involvement of MF, we conducted a systematic review to better define characteristics, treatments, outcomes, and mortality in these patients. Our analyses indicated that neurologic surveillance after the diagnosis of MF is crucial. Review of systems should include change in mentation, vestibular, and ocular symptoms. Progression to CNS involvement does not always occur in tandem with cutaneous...
Source: Leukemia Research Reports - July 5, 2018 Category: Hematology Source Type: research
Diagnostic and therapeutic implications of genetic heterogeneity in myeloid neoplasms uncovered by comprehensive mutational analysis
Publication date: 2017Source: Leukemia Research Reports, Volume 8Author(s): Sarah M. Choi, Ben Goldenson, Lo Ann Peterson, Shira Dinner, Brady L. Stein, Amir BehdadAbstractWhile growing use of comprehensive mutational analysis has led to the discovery of innumerable genetic alterations associated with various myeloid neoplasms, the under-recognized phenomenon of genetic heterogeneity within such neoplasms creates a potential for diagnostic confusion. Here, we describe two cases where expanded mutational testing led to amendment of an initial diagnosis of chronic myelogenous leukemia with subsequent altered treatment of eac...
Source: Leukemia Research Reports - July 5, 2018 Category: Hematology Source Type: research
EB virus reactivation triggers thrombotic thrombocytopenic purpura in a healthy adult
Publication date: 2017Source: Leukemia Research Reports, Volume 8Author(s): Satoko Oka, Masaharu NohgawaAbstractThrombotic thrombocytopenic purpura (TTP) is rare but life-threatening disease, characterized typically by microangiopathic hemolytic anemia (MAHA), profound peripheral thrombocytopenia and severe deficiency in the von Willebrand factor-cleaving prortease ADAMTS13. It has been reported that acquired immune TTP is closely associated with human immunodeficiency virus infection and influenza infection or vaccination. However, it has not been reported to be associated with Epstein Barr Virus infection or reactivation...
Source: Leukemia Research Reports - July 5, 2018 Category: Hematology Source Type: research
Successful salvage chemotherapy and allogeneic transplantation of an acute myeloid leukemia patient with disseminated Fusarium solani infection
We report a case of disseminated Fusarium in a patient with relapsed AML who underwent successful chemotherapy and haplo-identical allogeneic SCT with administration of granulocyte colony stimulating factor (G-CSF) and granulocyte infusions. (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - July 5, 2018 Category: Hematology Source Type: research
An unusual type of myeloid sarcoma localization following myelofibrosis: A case report and literature review
We report the case of a patient with MS following myelofibrosis with multiple subcutaneous, cutaneous and muscle localizations; the latter has been reported in the literature as anecdotal. In this way we aimed to enhance the understanding of this disease. (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - July 5, 2018 Category: Hematology Source Type: research
Essential thrombocytemia following immune thrombocytopenia with JAK2V617F mutation
Publication date: 2018Source: Leukemia Research Reports, Volume 9Author(s): Giovanni Caocci, Sandra Atzeni, Monica Usai, Giorgio La NasaAbstractJAK2V617F mutation is found in about 60% of cases of essential thrombocytemia (ET) and represents a driving mutation. Immune thrombocytopenia (ITP) is an autoimmune disease characterized by a low platelet (PLT) count. So far, only 2 reports described ET following ITP. For the first time we analyzed in a patient the JAK2V617F allele burden at ITP onset occurred 13 years before the ET diagnosis and found the presence of a small clone JAK2V617F positive clone (3%) raised to 27% in the...
Source: Leukemia Research Reports - July 5, 2018 Category: Hematology Source Type: research
Systemic lupus erythematosus and myelofibrosis: A case report and revision of literature
Publication date: 2018Source: Leukemia Research Reports, Volume 9Author(s): F. Del Porto, C. Tatarelli, A. Di Napoli, M. ProiettaAbstractBlood cytopenia represents one of the diagnostic criteria for systemic lupus erythematosus (SLE) and may occur as the first symptom of the disease. Antibody-mediated peripheral destruction of blood cells is the main cause of cytopenia observed in patients affected by SLE, however, inflammatory anemia, nutritional deficiencies, immunosuppressive therapy and, more rarely, myelofibrosis (MF) have also been documented. In the literature, 45 cases of autoimmune MF (AIMF) and SLE have been prev...
Source: Leukemia Research Reports - July 5, 2018 Category: Hematology Source Type: research
Secondary clonal hematologic neoplasia following successful therapy for acute promyelocytic leukemia (APL): A report of two cases and review of the literature
Publication date: 2018Source: Leukemia Research Reports, Volume 9Author(s): Daria Gaut, Joshua Sasine, Gary SchillerAbstractAlthough rare, secondary clonal hematologic neoplasia may occur after successful therapy for acute promyelocytic leukemia (APL). These secondary clonal events may be considered therapy-related, but may also be due to an underlying background of clonal hematopoiesis from which both malignancies may develop. In this manuscript, we describe two patients with secondary clones after APL therapy characterized in one patient by deletion of chromosome 11q23 and, in the other, by monosomy of chromosome 7, and ...
Source: Leukemia Research Reports - July 5, 2018 Category: Hematology Source Type: research
Sezary syndrome manifesting as posttransplant lymphoproliferative disorder
We present a patient with myelodysplastic syndrome (MDS) post matched unrelated donor alloHSCT who was on long-term immunosuppressive therapy due to graft versus host disease. Three years after an alloHSCT, she developed generalized erythroderma and peripheral blood lymphocytosis. Both skin biopsy and peripheral blood flow cytometry revealed atypical CD4+ T-cell population consistent with diagnosis of Sezary syndrome. Chimerism studies revealed 100% donor engraftment. Therapy with extracorporeal photopheresis resulted in complete response in blood and skin.Graphical abstract (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - July 5, 2018 Category: Hematology Source Type: research
Incident adverse events following therapy for acute promyelocytic leukemia
Publication date: 2018Source: Leukemia Research Reports, Volume 9Author(s): Peter Geon Kim, Kelly Bridgham, Evan C Chen, Mahesh K Vidula, Olga Pozdnyakova, Andrew M Brunner, Amir T. FathiAbstractThe use of all-trans retinoic acid (ATRA) combined with arsenic trioxide (ATO) with or without cytotoxic chemotherapy is highly effective in acute promyelocytic leukemia (APL) but incident chronic adverse events (AEs) after initiation of therapy are not well understood. We retrospectively analyzed adult patients with newly diagnosed APL from 2004 through 2014 to identify incident AEs following treatment and contributing risk factor...
Source: Leukemia Research Reports - July 5, 2018 Category: Hematology Source Type: research
Case report: Exome sequencing identifies T-ALL with myeloid features as a IKZF1-struck early precursor T-cell malignancy
Publication date: 2018Source: Leukemia Research Reports, Volume 9Author(s): Marcus C. Hansen, Line Nederby, Eigil Kjeldsen, Marianne A. Petersen, Hans B. Ommen, Peter Hokland (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - July 5, 2018 Category: Hematology Source Type: research
Alemtuzumab-based therapy for Secondary Malignant Histiocytosis arising from Pre-B-ALL
This report is the first to highlight the role of alemtuzumab, an anti-CD52 monoclonal antibody, in clonal disorders originating from transdifferentiation.•The alemtuzumab-based regimen should be reserved only for carefully selected allogeneic transplant patients. (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - July 5, 2018 Category: Hematology Source Type: research
Expression of a specific extracellular matrix signature is a favorable prognostic factor in acute myeloid leukemia
Publication date: 2018Source: Leukemia Research Reports, Volume 9Author(s): Valerio Izzi, Juho Lakkala, Raman Devarajan, Eeva-Riitta Savolainen, Pirjo Koistinen, Ritva Heljasvaara, Taina PihlajaniemiAbstractRelapse of acute myeloid leukemia (AML) is still dramatically frequent, imposing the need for early markers to quantify such risk. Recent evidence point to a prominent role for extracellular matrix (ECM) in AML, but its prognostic value has not yet been investigated. Here we have investigated whether the expression of a 15-ECM gene signature could be applied to clinical AML research evaluating a retrospective cohort of ...
Source: Leukemia Research Reports - July 5, 2018 Category: Hematology Source Type: research
Acute myeloid leukemia with t(4;12)(q12;p13) treated with an allogeneic stem cell transplant: A case report and review of the literature
Publication date: 2018Source: Leukemia Research Reports, Volume 9Author(s): Christie Hancock, Dimitra Kanaloupitis, Ronald Sirota, Jillene Kogan, Leonard Klein, John Eklund (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - July 5, 2018 Category: Hematology Source Type: research
