Retrospective analysis of primary plasma cell leukemia in Kansai Myeloma Forum registry
Publication date: Available online 4 July 2018Source: Leukemia Research ReportsAuthor(s): Aya Nakaya, Hideo Yagi, Hitomi Kaneko, Satoru Kosugi, Toru Kida, Yoko Adachi, Hirohiko Shibayama, Takae Kohara, Yuri Kamitsuji, Shin-ichi Fuchida, Nobuhiko Uoshima, Eri Kawata, Hitoji Uchiyama, Yuji Shimura, Takayuki Takahashi, Fumiaki Urase, Kensuke Ohta, Tsuneyoshi Hamada, Kazue Miyamoto, Masayuki KobayashiAbstractWe retrospectively analyzed twenty-six patients with primary plasma cell leukemia (pPCL) registered from May 2005 until April 2015 by the Kansai Myeloma Forum. Twenty patients received novel agents (bortezomib or lenalidom...
Source: Leukemia Research Reports - July 5, 2018 Category: Hematology Source Type: research
Retrospective analysis of primary plasma cell leukemia in Kansai Myeloma Forum registry
Publication date: Available online 4 July 2018 Source:Leukemia Research Reports Author(s): Aya Nakaya, Hideo Yagi, Hitomi Kaneko, Satoru Kosugi, Toru Kida, Yoko Adachi, Hirohiko Shibayama, Takae Kohara, Yuri Kamitsuji, Shin-ichi Fuchida, Nobuhiko Uoshima, Eri Kawata, Hitoji Uchiyama, Yuji Shimura, Takayuki Takahashi, Fumiaki Urase, Kensuke Ohta, Tsuneyoshi Hamada, Kazue Miyamoto, Masayuki Kobayashi, Maki Shindo, Hirokazu Tanaka, Chihiro Shimazaki, Masayuki Hino, Junya Kuroda, Yuzuru Kanakura, Akifumi Takaoari-Kondo, Shosaku Nomura, Itaru Matsumura We retrospectively analyzed twenty-six patien...
Source: Leukemia Research Reports - July 5, 2018 Category: Hematology Source Type: research
Tumor necrosis factor- and interleukin-6-producing high-grade B-cell lymphoma, not otherwise specified in the pleura
Publication date: Available online 28 June 2018 Source:Leukemia Research Reports Author(s): Shoko Nakayama, Mitsuhiro Matsuda, Tatsuya Adachi, Sanae Sueda, Kayo Ueda, Kunimitsu Kawahara, Yuka Ohashi, Sumie Awaji, Shigeo Hashimoto, Itaru Matsumura A 65-year-old man was admitted to our hospital with left-sided chest and back pain and dyspnea. Computed tomography demonstrated a marked circumferential left pleural thickening. A thoracoscopic pleural biopsy led to a diagnosis of high-grade B-cell lymphoma, not otherwise specified (HGBL, NOS). Lymphoma cells were positive for tumor necrosis factor (TNF) and interleuk...
Source: Leukemia Research Reports - June 29, 2018 Category: Hematology Source Type: research
Clinical Characteristics and Treatment Outcome of Patients with Isochromosome 17q (i17q) Abnormality and Myeloid Neoplasms: A Single Center Experience
Publication date: Available online 20 June 2018 Source:Leukemia Research Reports Author(s): Siddhartha Ganguly, Mason Uvodich, Ajoy Dias, Joseph P. McGuirk (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - June 21, 2018 Category: Hematology Source Type: research
Effects of Nilotinib on Platelet Function in Patients with Chronic Myeloid Leukemia in Chronic Phase
Conclusion Nilotinib had no adverse effect on platelet function nor patients clotting tests. (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - June 20, 2018 Category: Hematology Source Type: research
Acute Myeloid Leukemia with t(4;12)(q12;p13) treated with an Allogeneic Stem Cell Transplant: A case report and review of the literature
Publication date: Available online 6 May 2018 Source:Leukemia Research Reports Author(s): Christie Hancock, Dimitra Kanaloupitis, Ronald Sirota, Jillene Kogan, Leonard Klein, John Eklund (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - May 7, 2018 Category: Hematology Source Type: research
Incident Adverse Events Following Therapy for Acute Promyelocytic Leukemia
Publication date: Available online 5 May 2018 Source:Leukemia Research Reports Author(s): Peter Geon Kim, Kelly Bridgham, Evan C Chen, Mahesh K Vidula, Olga Pozdnyakova, Andrew M Brunner, Amir T. Fathi The use of all-trans retinoic acid (ATRA) combined with arsenic trioxide (ATO) with or without cytotoxic chemotherapy is highly effective in acute promyelocytic leukemia (APL) but incident chronic adverse events (AEs) after initiation of therapy are not well understood. We retrospectively analyzed adult patients with newly diagnosed APL from 2004 through 2014 to identify incident AEs following treatment and contribu...
Source: Leukemia Research Reports - May 6, 2018 Category: Hematology Source Type: research
Sezary Syndrome Manifesting as Posttransplant Lymphoproliferative Disorder
We present a patient with myelodysplastic syndrome (MDS) post matched unrelated donor alloHSCT who was on long-term immunosuppressive therapy due to graft versus host disease. Three years after an alloHSCT, she developed generalized erythroderma and peripheral blood lymphocytosis. Both skin biopsy and peripheral blood flow cytometry revealed atypical CD4+ T-cell population consistent with diagnosis of Sezary syndrome. Chimerism studies revealed 100% donor engraftment. Therapy with extracorporeal photopheresis resulted in complete response in blood and skin. Graphical abstract (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - May 2, 2018 Category: Hematology Source Type: research
Secondary Clonal Hematologic Neoplasia Following Successful Therapy for Acute Promyelocytic Leukemia (APL): A Report of Two Cases and Review of the Literature
Publication date: Available online 16 April 2018 Source:Leukemia Research Reports Author(s): Daria Gaut, Joshua Sasine, Gary Schiller Although rare, secondary clonal hematologic neoplasia may occur after successful therapy for acute promyelocytic leukemia (APL). These secondary clonal events may be considered therapy-related, but may also be due to an underlying background of clonal hematopoiesis from which both malignancies may develop. In this manuscript, we describe two patients with secondary clones after APL therapy characterized in one patient by deletion of chromosome 11q23 and, in the other, by monosomy chromo...
Source: Leukemia Research Reports - April 19, 2018 Category: Hematology Source Type: research
Anti-CD19 chimeric antigen receptor targeting of CD19 + acute myeloid leukemia
Publication date: 2018 Source:Leukemia Research Reports, Volume 9 Author(s): Gina Ma, Yi Wang, Tahmeena Ahmed, Ann-Leslie Zaslav, Laura Hogan, Cecilia Avila, Masayuki Wada, Huda Salman Aberrant expression of CD19 in acute myeloid leukemia (AML) is commonly associated with t(8;21)(q22;q22), although AML cases lacking this translocation occasionally express CD19. Mixed-phenotype acute leukemia also frequently expresses CD19. Chimeric antigen receptor (CAR) technology is a major breakthrough for cancer treatment, with the recent approval of CD19-directed CAR (CD19CAR) for treating B-cell malignancies. However, littl...
Source: Leukemia Research Reports - April 12, 2018 Category: Hematology Source Type: research
Systemic lupus erythematosus and myelofibrosis: a case report and revision of literature
Publication date: Available online 10 April 2018 Source:Leukemia Research Reports Author(s): F. Del Porto, C. Tatarelli, A. Di Napoli, M. Proietta Blood cytopenia represents one of the diagnostic criteria for systemic lupus erythematosus (SLE) and may occur as the first symptom of the disease. Antibody-mediated peripheral destruction of blood cells is the main cause of cytopenia observed in patients affected by SLE, however, inflammatory anemia, nutritional deficiencies, immunosuppressive therapy and, more rarely, myelofibrosis (MF) have also been documented. In the literature, 45 cases of autoimmune MF (AIMF) and SL...
Source: Leukemia Research Reports - April 10, 2018 Category: Hematology Source Type: research
A case of chronic eosinophilic leukemia with secondary transformation to acute myeloid leukemia
We describe a case of CEL-NOS with two hierarchically related non-specific cytogenetic rearrangements, associated with an NPM1 mutation and followed by evolution to secondary AML. NPM1 mutations are not previously described in CEL-NOS. (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - April 9, 2018 Category: Hematology Source Type: research
Delayed diagnosis of Shwachman diamond syndrome with short telomeres and a review of cases in Asia
We report a case of delayed diagnosis of SDS in a family with another child with aplastic anemia, and review reported cases of SDS in Asia. This highlights the gap in identifying inherited bone marrow failure syndromes in adults with hematologic malignancies. (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - April 9, 2018 Category: Hematology Source Type: research
The Fear of Lymphadenopathy: A Cautionary Case of Sarcoidosis Masquerading as Recurrent Diffuse Large B-cell Lymphoma (DLBCL)
We describe the cautionary case of a patient with advanced-stage large B-cell lymphoma (DLBCL). After combination chemotherapy, CT-PET revealed a persistent focus of likely DLBCL for which he received radiotherapy. Follow-up CT-PET showed diffuse hypermetabolic adenopathy and recurrent DLBCL was presumed. As part of clinical trial assessment, multiple biopsies showed non-caseating lymphadenitis consistent with sarcoidosis. No treatment for asymptomatic sarcoidosis was required and 18 months later he remains cancer-free. The presentation of sarcoidosis masquerading as recurrent DLBCL highlights the importance of tissue samp...
Source: Leukemia Research Reports - April 9, 2018 Category: Hematology Source Type: research
Anti-CD19 Chimeric Antigen Receptor Targeting of CD19+ Acute Myeloid Leukemia
Publication date: Available online 27 March 2018 Source:Leukemia Research Reports Author(s): Gina Ma, Yi Wang, Tahmeena Ahmed, Ann-Leslie Zaslav, Laura Hogan, Cecilia Avila, Masayuki Wada, Huda Salman Aberrant expression of CD19 in acute myeloid leukemia (AML) is commonly associated with t(8;21)(q22;q22), although AML cases lacking this translocation occasionally express CD19. Mixed-phenotype acute leukemia also frequently expresses CD19. Chimeric antigen receptor (CAR) technology is a major breakthrough for cancer treatment, with the recent approval of CD19-directed CAR (CD19CAR) for treating B-cell malignancies...
Source: Leukemia Research Reports - March 27, 2018 Category: Hematology Source Type: research
