The Role of FLT3 inhibitors as Maintenance Therapy Following Hematopoietic Stem Cell Transplant
Publication date: Available online 19 July 2018Source: Leukemia Research ReportsAuthor(s): Grace Xiuqing Li, Lan Wang, Bassam Yaghmour, Giridharan Ramsingh, George YaghmourAbstractActivating mutations in FLT3 in acute myeloid leukemia (AML) portend a poor prognosis, and targeting FLT3 with a tyrosine kinase inhibitor has been an area of intense research recently. Most FLT3 mutated AML patients undergo hematopoietic stem cell transplantation (HSCT) as standard of care but a significant proportion of patients relapse. Although the use of FLT3 inhibitors in the pre-HSCT perspective is more clearly defined, its use in the post...
Source: Leukemia Research Reports - July 20, 2018 Category: Hematology Source Type: research
Primary Isolated Bone Marrow Diffuse Large B Cell Lymphoma with Long-Term Complete Remission
Publication date: Available online 11 July 2018Source: Leukemia Research ReportsAuthor(s): Hiroko Nishida, Hiroshi Suzuki, Masao Hori, Katsuyuki ObaraAbstractSecondary bone marrow involvement of non-Hodgkin's lymphoma (NHL) is relatively common. However, primary isolated bone marrow involvement in NHL which was successfully treated and remains in complete remission (CR) for a long-term duration without any relapse is extremely rare. We herein report a patient of primary bone marrow diffuse large B cell lymphoma (PBML/DLBCL) who presented a prolonged high-grade fever and systemic purpura due to severe thrombocytopenia. The ...
Source: Leukemia Research Reports - July 12, 2018 Category: Hematology Source Type: research
Acute promyelocytic leukemia presenting with features of metastatic osseous disease
We report an unusual case of APL in a 59 year old female without peripheral blood abnormalities or diffuse marrow involvement. Clinical and radiographic findings were initially interpreted as metastatic osseous disease but ultimately found to be APL. (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - July 10, 2018 Category: Hematology Source Type: research
Tumor necrosis factor- and interleukin-6-producing high-grade B-cell lymphoma, not otherwise specified in the pleura
Publication date: 2018Source: Leukemia Research Reports, Volume 10Author(s): Shoko Nakayama, Mitsuhiro Matsuda, Tatsuya Adachi, Sanae Sueda, Kayo Ueda, Kunimitsu Kawahara, Yuka Ohashi, Sumie Awaji, Shigeo Hashimoto, Itaru MatsumuraAbstractA 65-year-old man was admitted to our hospital with left-sided chest and back pain and dyspnea. Computed tomography demonstrated a marked circumferential left pleural thickening. A thoracoscopic pleural biopsy led to a diagnosis of high-grade B-cell lymphoma, not otherwise specified (HGBL, NOS). Lymphoma cells were positive for tumor necrosis factor (TNF) and interleukin-6. This is the fi...
Source: Leukemia Research Reports - July 10, 2018 Category: Hematology Source Type: research
Retrospective analysis of primary plasma cell leukemia in Kansai Myeloma Forum registry
Publication date: 2018Source: Leukemia Research Reports, Volume 10Author(s): Aya Nakaya, Hideo Yagi, Hitomi Kaneko, Satoru Kosugi, Toru Kida, Yoko Adachi, Hirohiko Shibayama, Takae Kohara, Yuri Kamitsuji, Shin-ichi Fuchida, Nobuhiko Uoshima, Eri Kawata, Hitoji Uchiyama, Yuji Shimura, Takayuki Takahashi, Fumiaki Urase, Kensuke Ohta, Tsuneyoshi Hamada, Kazue Miyamoto, Masayuki KobayashiAbstractWe retrospectively analyzed twenty-six patients with primary plasma cell leukemia (pPCL) registered from May 2005 until April 2015 by the Kansai Myeloma Forum. Twenty patients received novel agents (bortezomib or lenalidomide), and the...
Source: Leukemia Research Reports - July 10, 2018 Category: Hematology Source Type: research
Case report: Exome sequencing identifies T-ALL with myeloid features as a IKZF1-struck early precursor T-cell malignancy
Publication date: 2018Source: Leukemia Research Reports, Volume 9Author(s): Marcus C. Hansen, Line Nederby, Eigil Kjeldsen, Marianne A. Petersen, Hans B. Ommen, Peter Hokland (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - July 10, 2018 Category: Hematology Source Type: research
Alemtuzumab-based therapy for Secondary Malignant Histiocytosis arising from Pre-B-ALL
This report is the first to highlight the role of alemtuzumab, an anti-CD52 monoclonal antibody, in clonal disorders originating from transdifferentiation.•The alemtuzumab-based regimen should be reserved only for carefully selected allogeneic transplant patients. (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - July 10, 2018 Category: Hematology Source Type: research
Expression of a specific extracellular matrix signature is a favorable prognostic factor in acute myeloid leukemia
Publication date: 2018Source: Leukemia Research Reports, Volume 9Author(s): Valerio Izzi, Juho Lakkala, Raman Devarajan, Eeva-Riitta Savolainen, Pirjo Koistinen, Ritva Heljasvaara, Taina PihlajaniemiAbstractRelapse of acute myeloid leukemia (AML) is still dramatically frequent, imposing the need for early markers to quantify such risk. Recent evidence point to a prominent role for extracellular matrix (ECM) in AML, but its prognostic value has not yet been investigated. Here we have investigated whether the expression of a 15-ECM gene signature could be applied to clinical AML research evaluating a retrospective cohort of ...
Source: Leukemia Research Reports - July 10, 2018 Category: Hematology Source Type: research
Essential thrombocytemia following immune thrombocytopenia with JAK2V617F mutation
Publication date: 2018Source: Leukemia Research Reports, Volume 9Author(s): Giovanni Caocci, Sandra Atzeni, Monica Usai, Giorgio La NasaAbstractJAK2V617F mutation is found in about 60% of cases of essential thrombocytemia (ET) and represents a driving mutation. Immune thrombocytopenia (ITP) is an autoimmune disease characterized by a low platelet (PLT) count. So far, only 2 reports described ET following ITP. For the first time we analyzed in a patient the JAK2V617F allele burden at ITP onset occurred 13 years before the ET diagnosis and found the presence of a small clone JAK2V617F positive clone (3%) raised to 27% in the...
Source: Leukemia Research Reports - July 10, 2018 Category: Hematology Source Type: research
Subcutaneous rituximab given to patients for other indications than CD20+ B-cell lymphoma: A monocentric study of 20 cases
Publication date: 2018Source: Leukemia Research Reports, Volume 9Author(s): Pierre Peterlin, Thierry Guillaume, Alice Garnier, Amandine Le Bourgeois, Beatrice Mahé, Viviane Dubruille, Nicolas Blin, Pierre Gallas, Cyrille Touzeau, Thomas Gastinne, Anne Lok, Patrick Thomare, Cecile Chauvin, Steven Le Gouill, Philippe Moreau, Patrice Chevallier (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - July 10, 2018 Category: Hematology Source Type: research
Unrelated HLA mismatched microtransplantation in a patient with refractory secondary acute myeloid leukemia
We describe the first reported patient with refractory AML who underwent salvage MST from an unrelated, complete HLA-mismatched donor. The patient achieved remission without complication, warranting further study of unrelated HLA-mismatched donor MST in AML. (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - July 10, 2018 Category: Hematology Source Type: research
Rituximab monotherapy become an optimal treatment for primary pulmonary malt lymphoma
Publication date: 2018Source: Leukemia Research Reports, Volume 9Author(s): A.I. Alvarez-Sánchez, C. Martínez-Losada (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - July 10, 2018 Category: Hematology Source Type: research
A rare case of a minimally secretory plasma cell leukemia with a hemorrhagic gastric plasmacytoma
Publication date: 2018Source: Leukemia Research Reports, Volume 9Author(s): Akshjot Puri, Michelle W. Lau, Xianfeng F. Zhao, Keith C. Chan, Kimberly Bader (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - July 10, 2018 Category: Hematology Source Type: research
Forskolin attenuates doxorubicin-induced accumulation of asymmetric dimethylarginine and s-adenosylhomocysteine via methyltransferase activity in leukemic monocytes
Publication date: 2018Source: Leukemia Research Reports, Volume 9Author(s): Sandhiya Ramachandran, Swetha Loganathan, Vinnie Cheeran, Soniya Charles, Ganesh Munuswamy-Ramanujan, Mohankumar Ramasamy, Vijay Raj, Kanchana MalaAbstractDoxorubicin (DOX) is an antitumor drug, associated with cardiomyopathy. Strategies to address DOX-cardiomyopathy are scarce. Here, we identify the effect of forskolin (FSK) on DOX-induced-asymmetric-dimethylarginine (ADMA) accumulation in monocytoid cells. DOX-challenge led to i) augmented cytotoxicity, reactive-oxygen-species (ROS) production and methyltransferase-enzyme-activity identified as A...
Source: Leukemia Research Reports - July 10, 2018 Category: Hematology Source Type: research
Secondary pure red cell aplasia in multiple myeloma treated with lenalidomide
Publication date: 2018Source: Leukemia Research Reports, Volume 10Author(s): Tomoki Ito, Aya Nakaya, Shinya Fujita, Atsushi Satake, Takahisa Nakanishi, Yoshiko Azuma, Yukie Tsubokura, Akiko Konishi, Masaaki Hotta, Hideaki Yoshimura, Kazuyoshi Ishii, Shosaku NomuraAbstractPure red cell aplasia (PRCA) is a rare disorder characterized by marked erythroid hypoplasia with maturation arrest in the bone marrow. Secondary acquired PRCA may be associated with hematologic disorders. A few case reports have described PRCA associated with multiple myeloma (MM). However, the clinical course and mechanism of PRCA associated with MM rema...
Source: Leukemia Research Reports - July 10, 2018 Category: Hematology Source Type: research
