Pseudo-Guillain –Barré syndrome masking acute myeloid leukemia relapse: Brief report and review
Publication date: 2015 Source:Leukemia Research Reports, Volume 4, Issue 2 Author(s): Fadi El Karak, Elie El Rassy, Samer Tabchi, Eliane Chouery, Andre Megarbane, Joseph Kattan Central nervous system (CNS) relapse is not a rare presentation in acute myeloid leukemia (AML) as its incidence ranges between 2% and 9%. It manifests with meningeal leukemia, cranial nerve palsies or cerebral mesenchymal myeloid sarcoma. We herein report the case of a 69 year-old female that presented a pseudo-Guillain–Barré syndrome masking an AML CNS relapse. Her symptoms completely resolved upon administration of a tailored t...
Source: Leukemia Research Reports - June 17, 2016 Category: Hematology Source Type: research
Acute myeloid leukemia in the older adults
Publication date: Available online 16 June 2016 Source:Leukemia Research Reports Author(s): Antonio M Almeida, Fernando Ramos AML is an aggressive hematological malignancy with highest incidence in the older adults. The adverse features of AML in the elderly, and the frailties and comorbidities frequently present in them, make their management a particularly difficult therapeutic challenge. In this context, it is important to assess carefully patient- as well as disease-associated prognostic features with validated tools. The fittest patients should be considered for curative therapy, such as bone marrow transplant...
Source: Leukemia Research Reports - June 16, 2016 Category: Hematology Source Type: research
Genomic imbalances in peripheral blood confirm the diagnosis of myelodysplastic syndrome in a patient presenting with non-immune hemolytic anemia
This report highlights the importance of suspecting MDS in patients with cytopenias and microangiopathic hemolytic anemia. CMA of peripheral blood may assist in the preliminary diagnosis of MDS, representing a comparatively less invasive diagnostic procedure and may aid bone marrow evaluation when aspirate sample is insufficient for conventional cytogenetic analysis. (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - May 13, 2016 Category: Hematology Source Type: research
Erythroid blast crisis in Chronic Myelogenous Leukemia: Case report and Review of Literature
We report a case of 41-year-old patient with CML who failed to achieve cytogenetic remission, transformed to acute erythroid leukemia and eventually succumbed to the disease over a short period of time. Related literature is also reviewed (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - April 26, 2016 Category: Hematology Source Type: research
The formation of an aberrant PAX5 transcript in a patient with mixed phenotype acute leukemia harboring der(9)t(7;9)(q11.2;p13)
Publication date: Available online 12 April 2016 Source:Leukemia Research Reports Author(s): Jun Amaki, Hiromichi Matsushita, Yuka Kitamura, Ryoko Nagao, Hiromichi Murayama, Minoru Kojima, Kiyoshi Ando We experienced the case of a 56-year-old male with B-lymphoid/myeloid lineage mixed phenotype acute leukemia (MPAL). A cytogenetic analysis of the patient's bone marrow revealed a complex karyotype, including der(9)t(7;9)(q11.2;p13). We identified an aberrant PAX5 transcript, including the exons 1A to 5 and the contiguous intron 5/6 sequence using the 3’ rapid amplification of cDNA ends-polymerase chain r...
Source: Leukemia Research Reports - April 15, 2016 Category: Hematology Source Type: research
Young woman with mild bone marrow dysplasia, GATA2 and ASXL1 mutation treated with allogeneic hematopoietic stem cell transplantation
We describe a case of symptomatic DCML deficiency and rather discrete bone marrow findings due to GATA2 mutation. Exome sequencing revealed a somatic ASXL1 mutation and the patient underwent allogeneic stem cell transplantation successfully. (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - February 26, 2016 Category: Hematology Source Type: research
Refractory acute promyelocytic leukemia successfully treated with combination therapy of arsenic trioxide and tamibarotene: A case report
Publication date: 2016 Source:Leukemia Research Reports, Volume 5 Author(s): Minoru Kojima, Daisuke Ogiya, Akifumi Ichiki, Ryujiro Hara, Jun Amaki, Hidetsugu Kawai, Hiroki Numata, Ai Sato, Mitsuki Miyamoto, Rikio Suzuki, Shinichiro Machida, Hiromichi Matsushita, Yoshiaki Ogawa, Hiroshi Kawada, Kiyoshi Ando A 40-year-old male developed refractory acute promyelocytic leukemia (APL) after various treatments including all-trans retinoic acid, tamibarotene, arsenic trioxide (As2O3), conventional chemotherapy, and autologous peripheral blood stem cell transplantation. We attempted to use both ta...
Source: Leukemia Research Reports - February 26, 2016 Category: Hematology Source Type: research
Clonal evolution of AML on novel FMS-like tyrosine kinase-3 (FLT3) inhibitor therapy with evolving actionable targets
We describe novel findings alongside data on treatment directed towards actionable aberrations acquired during the process. (Clinical Trial: NCT02014558; registered at: 〈https://clinicaltrials.gov/ct2/show/NCT02014558〉) (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - February 26, 2016 Category: Hematology Source Type: research
Four hepatosplenic T-cell lymphoma cases of Japanese patients
Publication date: 2016 Source:Leukemia Research Reports, Volume 5 Author(s): Hidetsugu Kawai, Hiromichi Matsushita, Ken Ohmachi, Minoru Kojima, Shinichiro Machida, Yoshiaki Ogawa, Hiroshi Kawada, Naoya Nakamura, Kiyoshi Ando Hepatosplenic T-cell lymphoma (HSTCL), a rare type of γδ T-cell lymphoma, is characterized by hepatosplenomegaly and cytopenias. It is associated with immunodeficiency and its age of onset is reportedly between the 20s and 30s. We herein report 4 Japanese HSTCL cases. Three of them, including an elderly case that was 74 years of age, were not at adolescence. No cases had a histo...
Source: Leukemia Research Reports - February 26, 2016 Category: Hematology Source Type: research
An unexpected and devastating adverse event of dasatinib: Rhabdomyolysis
Publication date: 2016 Source:Leukemia Research Reports, Volume 5 Author(s): Burak Uz, Ilhan Dolasik We, herein, describe a 52-year-old male whom developed rhabdomyolysis and acute renal failure likely related to dasatinib shortly after the administration of treatment. After withdrawal of dasatinib, the myalgia reduced, and his CK returned to normal levels within a week. On follow-up acute renal failure did resolve without requiring dialysis, but unfortunately the patient died of severe respiratory distress. We recommend that musculoskeletal symptoms should be monitorized during therapy with dasatinib, and CML pati...
Source: Leukemia Research Reports - February 26, 2016 Category: Hematology Source Type: research
Patterns of relapse and outcome of elderly multiple myeloma patients treated as front-line therapy with novel agents combinations
We report the characteristics of relapse, treatment response, and outcomes of 145 elderly patients with multiple myeloma in first relapse after front-line treatment with VMP or VTP. Reappearance of CRAB symptoms (113 patients) and more aggressive forms of disease (32 patients) were the most common patterns of relapse. After second-line therapy, 75 (51.7%) patients achieved at partial response and 16 (11%) complete response (CR). Overall survival was longer among patients receiving VMP as front-line induction (21.4vs. 14.4 months, P=0.037), in patients achieving CR (28.3vs. 14.8 months; P=0.04), and in patients without aggr...
Source: Leukemia Research Reports - September 25, 2015 Category: Hematology Source Type: research
Detection of a PDGFRB fusion in refractory CMML without eosinophilia: A case for broad spectrum tumor profiling
Publication date: Available online 24 September 2015 Source:Leukemia Research Reports Author(s): Gillian C. Bell, Eric Padron In this case report, we describe a refractory CMML case without eosinophilia harboring a PDGFRB rearrangement leading to a favorable response with imatinib. We believe this case demonstrates the utility of broad spectrum genomic profiling in refractory CMML cases as an opportunity to uncover additional treatment options. (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - September 25, 2015 Category: Hematology Source Type: research
Pharmacological targeting of PI3K isoforms as a therapeutic strategy in chronic lymphocytic leukaemia
Publication date: Available online 18 September 2015 Source:Leukemia Research Reports Author(s): Matthew D. Blunt, Andrew J. Steele PI3Kδ inhibitors such as idelalisib are providing improved therapeutic options for the treatment of chronic lymphocytic leukaemia (CLL). However under certain conditions, inhibition of a single PI3K isoform can be compensated by the other PI3K isoforms, therefore PI3K inhibitors which target multiple PI3K isoforms may provide greater efficacy. The development of compounds targeting multiple PI3K isoforms (α,β,γ,δ) in CLL cells, in vitro, resulted in sustained inhibition of BCR sig...
Source: Leukemia Research Reports - September 19, 2015 Category: Hematology Source Type: research
A radiolabeled antibody targeting CD123+ leukemia stem cells – initial radioimmunotherapy studies in NOD/SCID mice engrafted with primary human AML
Publication date: Available online 18 September 2015 Source:Leukemia Research Reports Author(s): Jeffrey V. Leyton, Catherine Gao, Brent Williams, Armand Keating, Mark Minden, Raymond M. Reilly Radioimmunotherapy (RIT) with anti-CD123 monoclonal antibody CSL360 modified with nuclear translocation sequence (NLS) peptides and labeled with the Auger electron-emitter, 111In (111In-NLS-CSL360) was studied in the prevalent NOD/SCID mouse AML engraftment assay. Significant decreases in CD123+ leukemic cells and impairment of leukemic stem cell self-renewal were achieved with high doses of RIT. However, NOD/SCID mi...
Source: Leukemia Research Reports - September 19, 2015 Category: Hematology Source Type: research
The YPEL5–PPP1CB fusion transcript is detected in different hematological malignancies and in normal samples
Publication date: 2015 Source:Leukemia Research Reports, Volume 4, Issue 2 Author(s): Karl Vandepoele, Jan Philippé, Barbara Denys Chronic lymphocytic leukemia (CLL) is the most frequent leukemia in Western adults. It was suggested that transcripts from a reciprocal trans-splicing event between YPEL5 and PPP1CB were present exclusively in CLL patients (more than 90%). Here we show that the YPEL5–PPP1CB fusion is not specific for CLL but is also detected in other hematological malignancies such as chronic myeloid leukemia, monoclonal B cell lymphocytosis or acute leukemia and also in normal samples. As such, it...
Source: Leukemia Research Reports - September 16, 2015 Category: Hematology Source Type: research
