A primary esophageal MALT lymphoma patient with Helicobacter pylori infection achieved complete remission after H. pylori eradication without anti-lymphoma treatment
We report a 76-year-old woman with esophageal lymphoma who achieved remission after Helicobacter pylori (HP) eradication. Esophagogastroduodenoscopy (EGD) revealed a mass in the lower esophagus, and she was diagnosed with stage IE mucosa-associated lymphoid tissue (MALT) lymphoma. She rejected any anti-lymphoma treatment except for HP eradication. Follow-up EGD demonstrated the disappearance of the esophageal MALT lymphoma 2 months after HP eradication, and she remained in remission for more than 3 years. Our results demonstrate that HP eradication may be effective as initial therapy in primary esophageal MALT lymphoma pat...
Source: Leukemia Research Reports - December 28, 2016 Category: Hematology Source Type: research
Renal cell carcinoma and hematological malignancies
Publication date: 2017 Source:Leukemia Research Reports, Volume 7 Author(s): Irfan Yavasoglu, Gokhan Sargin (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - December 28, 2016 Category: Hematology Source Type: research
Renal Cell Carcinoma and Hematogical Malignancies
Publication date: Available online 29 November 2016 Source:Leukemia Research Reports Author(s): Irfan Yavasoglu, Gokhan Sargin (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - November 29, 2016 Category: Hematology Source Type: research
An ETV6-ABL1 fusion in a patient with chronic myeloproliferative neoplasm: Initial response to Imatinib followed by rapid transformation into ALL
We report the case of a 26 year-old patient presenting with a persistent leukocytosis and CML-like marrow but no evidence of a BCR/ABL1 fusion. Molecular cytogenetics revealed that a portion of the ETV6 locus was inserted into the ABL1 locus. An ETV6/ABL1 fusion transcript could subsequently be confirmed. The patient was started on imatinib and went into complete cytomorphological remission. QRT-PCR measurements showed a 4log reduction of the ETV6/ABL1 fusion. 15 months later, the disease transformed into ALL and the patient expired. Thus, an ETV6/ABL1 fusion positive MPN has the potential to transform very rapidly into AL...
Source: Leukemia Research Reports - October 13, 2016 Category: Hematology Source Type: research
Novel therapeutic options in Acute Myeloid Leukemia
Publication date: Available online 1 October 2016 Source:Leukemia Research Reports Author(s): Michael Medinger, Claudia Lengerke, Jakob Passweg Acute myeloid leukemia (AML) is a biologically complex and molecularly and clinically heterogeneous disease, and its incidence is increasing as the population ages. Cytogenetic anomalies and mutation testing remain important prognostic tools for tailoring treatment after induction therapy. Despite major advances in understanding the genetic landscape of AML and its impact on the pathophysiology and biology of the disease, as well as the rapid development of new drugs, standard...
Source: Leukemia Research Reports - October 1, 2016 Category: Hematology Source Type: research
Involvement of CD147 on Multidrug Resistance through the Regulation of P-glycoprotein Expression in K562/ADR Leukemic Cell Line
This study aimed to investigate the correlation between CD147 and P-gp in the regulation of drug resistance in the K562/ADR leukemic cell line. The results showed that drug-resistant K562/ADR cells expressed significantly higher P-gp and CD147 levels than drug-free K562/ADR cells. To determine the regulatory effect of CD147 on P-gp expression, anti-CD147 antibody MEM-M6/6 significantly decreased P-gp and CD147 mRNA and protein levels. This is the first report to show that CD147 mediates MDR in leukemia through the regulation of P-gp expression. (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - August 26, 2016 Category: Hematology Source Type: research
Congenital B-lymphoblastic leukemia with a cryptic MLL rearrangement and post-treatment evolution to mixed phenotype acute leukemia
We report a case of congenital leukemia with a cryptic rearrangement of MLL demonstrable only with RT-PCR. Interestingly, with treatment, the patient showed lineage plasticity of the leukemia with the development of monocytic lineage blasts after presenting with B-cell lineage blasts. This was heralded by the development of a new clonal cytogenetic abnormality. This case highlights the primitive nature of the leukemic cells in congenital leukemia, and emphasizes that RT-PCR for MLL rearrangements may identify a subset of cases which are otherwise negative by karyotyping, FISH, and chromosomal microarrays. (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - August 19, 2016 Category: Hematology Source Type: research
The role of the Exon 13 G571S JAK2 mutation in myeloproliferative neoplasms
We present a case of a patient with erythrocytosis and an exon 13 G571S mutation, and discuss the putative role of this mutation in myeloproliferative neoplasms. (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - August 19, 2016 Category: Hematology Source Type: research
Enhanced international prognostic index in Japanese patients with diffuse large B-cell lymphoma
Publication date: 2016 Source:Leukemia Research Reports, Volume 6 Author(s): Aya Nakaya, Shinya Fujita, Atsushi Satake, Takahisa Nakanishi, Yoshiko Azuma, Yukie Tsubokura, Masaaki Hotta, Hideaki Yoshimura, Kazuyoshi Ishii, Tomoki Ito, Shosaku Nomura To evaluate the National Comprehensive Cancer Network (NCCN) International Prognostic Index (IPI), we analyzed 284 patients treated with the combination of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) in our institution in Japan. Their 5-year overall survival (OS) by risk level was 80.7%, 74.8%, 55.4% and 67.5% (P=0.005); and their...
Source: Leukemia Research Reports - August 19, 2016 Category: Hematology Source Type: research
A remarkable hematological and molecular response pattern in a patient with polycythemia vera during combination therapy with simvastatin and alendronate
We report a 57-year old man with polycythemia vera, who had a remarkable hematological and molecular response during treatment with simvastatin and alendronate. The patient was treated with this combination for 56 months, and during this period the patient has been in complete hematological remission. The JAK2-V617F allele burden has dropped from 64% to sustained values below 20%, and follow-up bone marrow biopsies have revealed no change in PV features, without any regular cytoreductive treatment. (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - August 19, 2016 Category: Hematology Source Type: research
Changing of IKZF1 genotype during Philadelphia-negative precursor-B acute lymphoblastic leukemia progression: a short clinical report
Publication date: 2016 Source:Leukemia Research Reports, Volume 6 Author(s): Volha Vshyukova, Alexander Meleshko, Natalia Mihal, Olga Aleinikova (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - August 19, 2016 Category: Hematology Source Type: research
A case of SRSF2 mutation in chronic lymphocytic leukemia
We report on a patient diagnosed with CLL, whose disease was characterized by episodes of rapid progression and disease stabilization, and in which a SRSF2 gene mutation was identified in the absence of other commonly known mutations of CLL. To the best of our knowledge this is the first case of SRSF2 gene mutation ever reported in CLL. (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - August 19, 2016 Category: Hematology Source Type: research
Chronic lymphocytic lymphoma and concomitant renal cell carcinoma (Clear Cell Type): Review of the literature
Publication date: 2016 Source:Leukemia Research Reports, Volume 6 Author(s): Burak Uz, Ilhan Dolasik, Ozlem Ucer, Adile Ferda Dagli, Sercan Simsek In the present report, a 73 years-old male patient who developed clear cell type renal cell carcinoma (RCC) 5 years after the diagnosis of chronic lymphocytic lymphoma (CLL) and plausible explanations for this association were discussed by the authors. The incidence of CLL and RCC occurring in the same patient is higher than that expected in the general population. Various explicative hypotheses of this concurrence include treatment-related development of a second maligna...
Source: Leukemia Research Reports - August 19, 2016 Category: Hematology Source Type: research
Interaction between IL-6 and TNF- α genotypes associated with bacteremia in multiple myeloma patients submitted to autologous stem cell transplantation (ASCT)
Publication date: 2014 Source:Leukemia Research Reports, Volume 3, Issue 2 Author(s): Fernanda M.B. Trigo, Marcelo R. Luizon, Hélio S. Dutra, Ângelo Maiolino, Márcio Nucci, Belinda P. Simões Stem cell transplantation affects patient׳s vulnerability to infections due to immunological changes related to chemotherapy. Multiple myeloma is characterized by susceptibility to infections, and IL-6 and TNF-α increased levels affect immune response (IR). Polymorphisms in promoter region of cytokine genes may alter expression levels and affect IR. We performed interaction analysis of IL-6 (−174G/C) and TNF-α ...
Source: Leukemia Research Reports - June 17, 2016 Category: Hematology Source Type: research
The YPEL5 –PPP1CB fusion transcript is detected in different hematological malignancies and in normal samples
Publication date: 2015 Source:Leukemia Research Reports, Volume 4, Issue 2 Author(s): Karl Vandepoele, Jan Philippé, Barbara Denys Chronic lymphocytic leukemia (CLL) is the most frequent leukemia in Western adults. It was suggested that transcripts from a reciprocal trans-splicing event between YPEL5 and PPP1CB were present exclusively in CLL patients (more than 90%). Here we show that the YPEL5–PPP1CB fusion is not specific for CLL but is also detected in other hematological malignancies such as chronic myeloid leukemia, monoclonal B cell lymphocytosis or acute leukemia and also in normal samples. As such, it...
Source: Leukemia Research Reports - June 17, 2016 Category: Hematology Source Type: research
