Interaction between IL-6 and TNF- α genotypes associated with bacteremia in multiple myeloma patients submitted to autologous stem cell transplantation (ASCT)

Publication date: 2014 Source:Leukemia Research Reports, Volume 3, Issue 2 Author(s): Fernanda M.B. Trigo, Marcelo R. Luizon, Hélio S. Dutra, Ângelo Maiolino, Márcio Nucci, Belinda P. Simões Stem cell transplantation affects patient׳s vulnerability to infections due to immunological changes related to chemotherapy. Multiple myeloma is characterized by susceptibility to infections, and IL-6 and TNF-α increased levels affect immune response (IR). Polymorphisms in promoter region of cytokine genes may alter expression levels and affect IR. We performed interaction analysis of IL-6 (−174G/C) and TNF-α (−308G/A) polymorphisms with infection susceptibility in 148 patients classified accordingly to infection status and found an interaction when compared groups with and without bacteremia (p=0.0380). The interaction may be more important than single effects for the IR associated with the infection susceptibility in ASCT.
Source: Leukemia Research Reports - Category: Hematology Source Type: research