1,25-OH2 vitamin D3 and AKT-inhibition increase glucocorticoid induced apoptosis in a model of T-cell acute lymphoblastic leukemia (ALL)
Publication date: 2018Source: Leukemia Research Reports, Volume 9Author(s): Maximilian Pistor, Lisa Schrewe, Steffen Haupeltshofer, Andrei Miclea, Simon Faissner, Andrew Chan, Robert HoepnerAbstractIn acute lymphoblastic leukemia (ALL), steroid resistance and hypovitaminosis D are both associated with a poor prognosis. We show that methylprednisolone, calcitriol and the AKT-inhibitor MK-2206 have a synergistic effect on the apoptosis of steroid resistant T-ALL cells. Compared to methylprednisolone monotherapy, calcitriol increases methylprednisolone induced apoptosis dose-dependently (1.37–1.92-fold; p < 0.05). P...
Source: Leukemia Research Reports - July 10, 2018 Category: Hematology Source Type: research
Anti-CD19 chimeric antigen receptor targeting of CD19 + acute myeloid leukemia
Publication date: 2018Source: Leukemia Research Reports, Volume 9Author(s): Gina Ma, Yi Wang, Tahmeena Ahmed, Ann-Leslie Zaslav, Laura Hogan, Cecilia Avila, Masayuki Wada, Huda SalmanAbstractAberrant expression of CD19 in acute myeloid leukemia (AML) is commonly associated with t(8;21)(q22;q22), although AML cases lacking this translocation occasionally express CD19. Mixed-phenotype acute leukemia also frequently expresses CD19. Chimeric antigen receptor (CAR) technology is a major breakthrough for cancer treatment, with the recent approval of CD19-directed CAR (CD19CAR) for treating B-cell malignancies. However, little in...
Source: Leukemia Research Reports - July 10, 2018 Category: Hematology Source Type: research
A case of chronic eosinophilic leukemia with secondary transformation to acute myeloid leukemia
We describe a case of CEL-NOS with two hierarchically related non-specific cytogenetic rearrangements, associated with an NPM1 mutation and followed by evolution to secondary AML. NPM1 mutations are not previously described in CEL-NOS. (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - July 10, 2018 Category: Hematology Source Type: research
The fear of lymphadenopathy: A cautionary case of sarcoidosis masquerading as recurrent diffuse large b-cell lymphoma (DLBCL)
We describe the cautionary case of a patient with advanced-stage large B-cell lymphoma (DLBCL). After combination chemotherapy, CT-PET revealed a persistent focus of likely DLBCL for which he received radiotherapy. Follow-up CT-PET showed diffuse hypermetabolic adenopathy and recurrent DLBCL was presumed. As part of clinical trial assessment, multiple biopsies showed non-caseating lymphadenitis consistent with sarcoidosis. No treatment for asymptomatic sarcoidosis was required and 18 months later he remains cancer-free. The presentation of sarcoidosis masquerading as recurrent DLBCL highlights the importance of tissue samp...
Source: Leukemia Research Reports - July 10, 2018 Category: Hematology Source Type: research
Delayed diagnosis of Shwachman diamond syndrome with short telomeres and a review of cases in Asia
We report a case of delayed diagnosis of SDS in a family with another child with aplastic anemia, and review reported cases of SDS in Asia. This highlights the gap in identifying inherited bone marrow failure syndromes in adults with hematologic malignancies. (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - July 10, 2018 Category: Hematology Source Type: research
Systemic lupus erythematosus and myelofibrosis: A case report and revision of literature
Publication date: 2018Source: Leukemia Research Reports, Volume 9Author(s): F. Del Porto, C. Tatarelli, A. Di Napoli, M. ProiettaAbstractBlood cytopenia represents one of the diagnostic criteria for systemic lupus erythematosus (SLE) and may occur as the first symptom of the disease. Antibody-mediated peripheral destruction of blood cells is the main cause of cytopenia observed in patients affected by SLE, however, inflammatory anemia, nutritional deficiencies, immunosuppressive therapy and, more rarely, myelofibrosis (MF) have also been documented. In the literature, 45 cases of autoimmune MF (AIMF) and SLE have been prev...
Source: Leukemia Research Reports - July 10, 2018 Category: Hematology Source Type: research
Secondary clonal hematologic neoplasia following successful therapy for acute promyelocytic leukemia (APL): A report of two cases and review of the literature
Publication date: 2018Source: Leukemia Research Reports, Volume 9Author(s): Daria Gaut, Joshua Sasine, Gary SchillerAbstractAlthough rare, secondary clonal hematologic neoplasia may occur after successful therapy for acute promyelocytic leukemia (APL). These secondary clonal events may be considered therapy-related, but may also be due to an underlying background of clonal hematopoiesis from which both malignancies may develop. In this manuscript, we describe two patients with secondary clones after APL therapy characterized in one patient by deletion of chromosome 11q23 and, in the other, by monosomy of chromosome 7, and ...
Source: Leukemia Research Reports - July 10, 2018 Category: Hematology Source Type: research
Sezary syndrome manifesting as posttransplant lymphoproliferative disorder
We present a patient with myelodysplastic syndrome (MDS) post matched unrelated donor alloHSCT who was on long-term immunosuppressive therapy due to graft versus host disease. Three years after an alloHSCT, she developed generalized erythroderma and peripheral blood lymphocytosis. Both skin biopsy and peripheral blood flow cytometry revealed atypical CD4+ T-cell population consistent with diagnosis of Sezary syndrome. Chimerism studies revealed 100% donor engraftment. Therapy with extracorporeal photopheresis resulted in complete response in blood and skin.Graphical abstract (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - July 10, 2018 Category: Hematology Source Type: research
Acute myeloid leukemia with t(4;12)(q12;p13) treated with an allogeneic stem cell transplant: A case report and review of the literature
Publication date: 2018Source: Leukemia Research Reports, Volume 9Author(s): Christie Hancock, Dimitra Kanaloupitis, Ronald Sirota, Jillene Kogan, Leonard Klein, John Eklund (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - July 10, 2018 Category: Hematology Source Type: research
Incident adverse events following therapy for acute promyelocytic leukemia
Publication date: 2018Source: Leukemia Research Reports, Volume 9Author(s): Peter Geon Kim, Kelly Bridgham, Evan C Chen, Mahesh K Vidula, Olga Pozdnyakova, Andrew M Brunner, Amir T. FathiAbstractThe use of all-trans retinoic acid (ATRA) combined with arsenic trioxide (ATO) with or without cytotoxic chemotherapy is highly effective in acute promyelocytic leukemia (APL) but incident chronic adverse events (AEs) after initiation of therapy are not well understood. We retrospectively analyzed adult patients with newly diagnosed APL from 2004 through 2014 to identify incident AEs following treatment and contributing risk factor...
Source: Leukemia Research Reports - July 10, 2018 Category: Hematology Source Type: research
Corrigendum to “Ibrutinib as a bridge to transplant in high-risk chronic lymphocytic leukemia: A case report and review of the literature” [Leukemia Res. Rep. 8 (2017) 21–23]
Publication date: Available online 19 March 2018Source: Leukemia Research ReportsAuthor(s): Annalisa Arcari, Simona Bassi, Lara Pochintesta, Elena Trabacchi, Carlo Filippo Moroni, Angela Rossi, Luca Zanlari, Daniele Vallisa (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - July 10, 2018 Category: Hematology Source Type: research
Effects of nilotinib on platelet function in patients with chronic myeloid leukemia in chronic phase
ConclusionNilotinib had no adverse effect on platelet function nor patients clotting tests. (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - July 10, 2018 Category: Hematology Source Type: research
Clinical characteristics and treatment outcome of patients with isochromosome 17q (i17q) abnormality and myeloid neoplasms: A single center experience
Publication date: Available online 20 June 2018Source: Leukemia Research ReportsAuthor(s): Siddhartha Ganguly, Mason Uvodich, Ajoy Dias, Joseph P. McGuirk (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - July 10, 2018 Category: Hematology Source Type: research
Secondary pure red cell aplasia in multiple myeloma treated with lenalidomide
Publication date: 2018Source: Leukemia Research Reports, Volume 10Author(s): Tomoki Ito, Aya Nakaya, Shinya Fujita, Atsushi Satake, Takahisa Nakanishi, Yoshiko Azuma, Yukie Tsubokura, Akiko Konishi, Masaaki Hotta, Hideaki Yoshimura, Kazuyoshi Ishii, Shosaku NomuraAbstractPure red cell aplasia (PRCA) is a rare disorder characterized by marked erythroid hypoplasia with maturation arrest in the bone marrow. Secondary acquired PRCA may be associated with hematologic disorders. A few case reports have described PRCA associated with multiple myeloma (MM). However, the clinical course and mechanism of PRCA associated with MM rema...
Source: Leukemia Research Reports - July 7, 2018 Category: Hematology Source Type: research
Ibrutinib as a bridge to transplant in high-risk chronic lymphocytic leukemia: A case report and review of the literature
Publication date: 2017Source: Leukemia Research Reports, Volume 8Author(s): Arcari Annalisa, Bassi Simona, Pochintesta Lara, Trabacchi Elena, Moroni Carlo Filippo, Rossi Angela, Zanlari Luca, Vallisa DanieleAbstractThe treatment landscape of chronic lymphocytic leukemia (CLL) has been challenged by the advent of novel classes of drugs, such as B-cell receptor (BCR)-inhibitors and BCL-2 antagonists. In selected high-risk patients, the choice to start allogeneic hematopoietic stem cell transplantation (alloHCT) or continue these agents is a matter of debate. Furthermore, published data about the impact on the feasibility of ...
Source: Leukemia Research Reports - July 5, 2018 Category: Hematology Source Type: research
