Unusual massive bone marrow fibrosis in acute promyelocytic leukemia following arsenic trioxide therapy

Publication date: Available online 15 July 2015 Source:Leukemia Research Reports Author(s): S Venkatesan, Abhishek Purohit, Ankur Ahuja, Dinesh Chandra, Mukul Aggarwal, R Amrita, Ravi Kumar, Manoranjan Mahapatra, Hara P Pati, Seema Tyagi Bone marrow fibrosis has been associated with different types of non-neoplastic conditions like granulomatous and autoimmune diseases and a variety of neoplastic disorders such as acute megakaryoblastic leukemia, Hodgkin Lymphoma, Non-Hodgkin Lymphoma and myeloproliferative neoplsms. Therapy induced fibrosis is a rare phenomenon. Here we report a case of an incidentally diagnosed Acute promyelocytic leukemia (APL) with t(11;17) which was treated with arsenic trioxide (ATO) for 45 days. However, the patient did not go into remission and developed massive fibrosis of bone marrow. Literature search doesnot reveal such documented marrow fibrosis following therapy with ATO in a case of APL.
Source: Leukemia Research Reports - Category: Hematology Source Type: research