Circulating miRNAs expression profiling in drug-resistant epilepsy: Up-regulation of miR-301a-3p in a case of sudden unexpected death
Sudden and unexpected death in epilepsy (SUDEP) represents one of the most challenging fields for clinical, forensic and preventative pathology [1 –3]. (Source: Legal Medicine)
Source: Legal Medicine - December 2, 2017 Category: Forensic Medicine Authors: Maria De Matteis, Giovanni Cecchetto, Giada Munari, Laura Balsamo, Marina Paola Gardiman, Renzo Giordano, Guido Viel, Matteo Fassan Tags: Case Report Source Type: research
Intimate partner violence against women, circumstances of aggressions and oral-maxillofacial traumas: A medical-legal and forensic approach
Intimate partner violence (IPV) is a serious public health problem whose magnitude and risk factors vary according to different social, economic and cultural scenarios [1 –5]. It can be defined as a pattern of coercive behavior perpetrated by current or former spouse, law partner, sexual partner or dating partner, which causes physical, sexual or psychological harm, including acts of physical aggression, sexual coercion, psychological abuse and control behaviors [6 ]. (Source: Legal Medicine)
Source: Legal Medicine - December 2, 2017 Category: Forensic Medicine Authors: Ítalo de Macedo Bernardino, Luzia Michelle Santos, Alysson Vinicius Porto Ferreira, Tomás Lucio Marques de Almeida Lima, Lorena Marques da Nóbrega, Sérgio d'Avila Source Type: research
Circulating miRNAs expression profiling in drug-resistant epilepsy: up-regulation of miR-301a-3p in a case of sudden unexpected death
Sudden and unexpected death in epilepsy (SUDEP) represents one of the most challenging fields for clinical, forensic and preventative pathology [1 –3]. (Source: Legal Medicine)
Source: Legal Medicine - December 2, 2017 Category: Forensic Medicine Authors: Maria De Matteis, Giovanni Cecchetto, Giada Munari, Laura Balsamo, Marina Paola Gardiman, Renzo Giordano, Guido Viel, Matteo Fassan Source Type: research
Intimate partner violence against women, circumstances of aggressions and oral-maxillofacial traumas: a medical-legal and forensic approach
Intimate partner violence (IPV) is a serious public health problem whose magnitude and risk factors vary according to different social, economic and cultural scenarios [1 –5]. It can be defined as a pattern of coercive behavior perpetrated by current or former spouse, law partner, sexual partner or dating partner, which causes physical, sexual or psychological harm, including acts of physical aggression, sexual coercion, psychological abuse and control behaviors [6 ]. (Source: Legal Medicine)
Source: Legal Medicine - December 2, 2017 Category: Forensic Medicine Authors: Ítalo de Macedo Bernardino, Luzia Michelle Santos, Alysson Vinicius Porto Ferreira, Tomás Lucio Marques de Almeida Lima, Lorena Marques da Nóbrega, Sérgio d'Avila Source Type: research
Development of a simultaneous identification method for 13 animal species using two multiplex real-time PCR assays and melting curve analysis
Crimes involving animal attacks on people or vice versa are unfortunately not uncommon. Obtaining forensic evidence to solve such crimes relies on collecting samples from the crime scene to enable identification of the animal species involved. Therefore, the ability to accurately identify animal species has been the subject of many studies in the forensic science field, and also in the food industry, where it is important to prevent improper food labeling and contamination of food with non-permitted species [1 –4]. (Source: Legal Medicine)
Source: Legal Medicine - November 24, 2017 Category: Forensic Medicine Authors: Natsumi Ishida, Makoto Sakurada, Hiroshi Kusunoki, Yasuhiro Ueno Source Type: research
Coronary Artery Tuberculosis: An Unusual Case of Sudden Death
Infection with Mycobacterium tuberculosis (TB) is very common worldwide, particularly in South Africa.[1,2] Progressive disease with extra-pulmonary manifestations is more common in immunosuppressed individuals, and unusual sites and presentations must be considered.[3] (Source: Legal Medicine)
Source: Legal Medicine - November 20, 2017 Category: Forensic Medicine Authors: Laura Peddle, Michael Otto Source Type: research
Usefulness of coronary postmortem computed tomography angiography to detect lesions in the coronary artery and myocardium in cases of sudden death
Postmortem computed tomography (PMCT) is becoming common in the practice of forensic medicine [1,2]. Postmortem CT angiography (PMCTA) has also proved to be a useful tool, mainly in forensic facilities and departments [3 –12]. PMCTA techniques comprise angiography at the time of terminal cardiopulmonary resuscitation, whole-body angiography, and selective angiography including targeted coronary angiography. Whole-body angiography using a modified heart-lung bypass machine and high volumes of contrast medium has de monstrated the systemic vascular circulation including coronary arteries, suggesting that it can be a non-in...
Source: Legal Medicine - November 16, 2017 Category: Forensic Medicine Authors: Hiroyuki Takei, Rie Sano, Yoichiro Takahashi, Keiko Takahashi, Yoshihiko Kominato, Hiroyuki Tokue, Takehiro Shimada, Sachiko Awata, Satoshi Hirasawa, Naoya Ohta Source Type: research
Utility of post mortem computed tomography in Clivus fracture diagnosis. Case illustration and literature review
The clivus is the strongest bone of the skull base, provides mechanical support for the cranial vault and protection for the brainstem and adjacent major vascular structures. Despite its deep location is very susceptible to related fractures with consequent high mortality rate or poor outcome for survivors [1 –2]. (Source: Legal Medicine)
Source: Legal Medicine - November 16, 2017 Category: Forensic Medicine Authors: S. Zerbo, A. Di Piazza, G. Lo Re, G.L. Aronica, S. Salerno, R. Lagalla Source Type: research
Forensic evaluation of STR typing reliability in lung cancer
Short tandem repeats (STRs), also known as microsatellites, are genomic DNA sequences that consist of repeating units (2 –6 bp) [1]. In eukaryotic genomes, STRs are extensively distributed in non-coding regions and characterized by co-dominant inheritance, high levels of polymorphisms, high reliability and good reproducibility; thus making them effective for forensic analysis [1,2]. As second generation genetic ma rks, STRs are broadly used in forensics for personal identification and paternity testing [2–4]. (Source: Legal Medicine)
Source: Legal Medicine - November 11, 2017 Category: Forensic Medicine Authors: Peng Zhang, Ying Zhu, Yongguo Li, Shisheng Zhu, Ruoxiang Ma, Minzhu Zhao, Jianbo Li Source Type: research
Forensic evaluation of reliability on STR typing in lung cancer
Short tandem repeats (STRs), alsoknownasmicrosatellites, are genomic DNA sequences that consist of repeatingunits (2 - 6 bp) [1]. In eukaryotic genomes, STRs are extensively distributed in non-codingregions and characterizedby co-dominant inheritance, high levels ofpolymorphisms, high reliability and goodreproducibility; thus making them effective for forensic analysis [1,2]. Assecond generation genetic marks, STRs are broadly used in forensics for personal identification and paternity testing [2 –4]. (Source: Legal Medicine)
Source: Legal Medicine - November 11, 2017 Category: Forensic Medicine Authors: Peng Zhang, Ying Zhu, Yongguo Li, Shisheng Zhu, Ruoxiang Ma, Minzhu Zhao, Jianbo Li Source Type: research
The importance of Saprinus semistriatus (Coleoptera: Histeridae) for estimating the minimum post-mortem interval
In forensic science, using entomological evidence to estimate the minimum post-mortem interval (PMImin) is a common practice [1,2]. Four different ecological groups of insects can be classified on a corpse: (1) necrophagous species that feed on the dead organic matter directly, (2) predators and parasites of insects and other arthropods, (3) omnivores and (4) adventive species [3]. The first two categories are most useful for forensic purposes [2]. However, within these two groups not all species are equally suitable [4]. (Source: Legal Medicine)
Source: Legal Medicine - November 10, 2017 Category: Forensic Medicine Authors: I. Szelecz, N. Feddern, C.V.W. Seppey, J. Amendt, E.A.D. Mitchell Source Type: research
Association of SNPs in genes encoding zinc transporters on blood zinc levels in humans
Zinc is the second most abundant micromineral in the human body and is essential for life. A deficiency of zinc can give rise to dermatitis, neurological disease, growth retardation, metabolic bone disease, and immunodeficiency [1]. In contrast, cases of poisoning following the ingestion of zinc compounds have been reported [2,3], and we have reported the toxicity ofzinc oxide nanoparticles [4 –6]. (Source: Legal Medicine)
Source: Legal Medicine - November 8, 2017 Category: Forensic Medicine Authors: Junko Fujihara, Toshihiro Yasuda, Kaori Kimura-Kataoka, Yoshikazu Takinami, Masataka Nagao, Haruo Takeshita Source Type: research
Assessing the FBI ’s Native American STR database for random match probability calculations
The impact of forensic DNA evidence in casework lies in its ability to generate robust random match probabilities (RMP) and/or likelihood ratios (LR) that are precise. These statistics are calculated using population allele frequencies generated from the Federal Bureau of Investigation ’s (FBI) Combined DNA Index System’s (CODIS) core short tandem repeat (STR) markers. Recently, the number of CODIS core STRs was expanded from 13 to 20 loci to increase the power of discrimination and compatibility internationally while also decreasing adventitious matches [1]. (Source: Legal Medicine)
Source: Legal Medicine - November 8, 2017 Category: Forensic Medicine Authors: Jillian Ng, Robert F. Oldt, Sreetharan Kanthaswamy Source Type: research
Postmortem biochemical investigation results in situations of fatal mechanical compression of the neck region
The thyroid and parathyroid glands are cervical endocrine glands responsible for metabolism-related functions. Like all endocrine organs, they are characterized by lack of ducts and secretion discharge directly into the bloodstream [1]. (Source: Legal Medicine)
Source: Legal Medicine - November 6, 2017 Category: Forensic Medicine Authors: Cristian Palmiere, Camilla Tettamanti, Maria Pia Scarpelli, Guillaume Rousseau, Coraline Egger, Massimo Bongiovanni Source Type: research
Highly sensitive determination of alendronate in human plasma and dialysate using metal-free HPLC-MS/MS
As a bisphosphonate, alendronate is a potent inhibitor of bone resorption and is widely used for the prevention and treatment of primary and secondary osteoporosis [1 –7]. Alendronate toxicity to soft tissues such as oral ulceration and acute pancreatitis has been pointed out [8-12]. Alendronate may induce osteonecrosis of the jaw if invasive dental procedures are performed [13,14]. If invasive dental procedures are performed. Hence, the discontinuation of the medication is highly required if the patient needs dental treatments. (Source: Legal Medicine)
Source: Legal Medicine - November 6, 2017 Category: Forensic Medicine Authors: Miho Yamada, Xiao-Pen Lee, Masaya Fujishiro, Ken Iseri, Makoto Waranabe, Hiroshi Sakamaki, Naoki Uchida, Takaaki Matsuyama, Takeshi Kumazawa, Haruo Takahashi, Akira Ishii, Keizo Sato Source Type: research
