Circulating miRNAs expression profiling in drug-resistant epilepsy: Up-regulation of miR-301a-3p in a case of sudden unexpected death
We have very appreciated the letter by F. A. Scorza and colleagues [1] confirming the interest of both clinicians and pathologists on the challenges posed by Sudden Unexpected Death in Epilepsy (SUDEP) [2]. Furthermore, we welcome the courteous questions that give us the opportunity to better explain our point of view on miRNA and SUDEP. (Source: Legal Medicine)
Source: Legal Medicine - April 18, 2018 Category: Forensic Medicine Authors: Maria De Matteis, Giovanni Cecchetto, Giada Munari, Laura Balsamo, Marina Paola Gardiman, Renzo Giordano, Guido Viel, Matteo Fassan Tags: Letter to Editor Source Type: research
microRNAs in Sudden Unexpected Death in Epilepsy (SUDEP): location matters.
We read with great enthusiasm the article published by De Matteis et al. who have elegantly demonstrated a significant up-regulation of microRNAs (miRNAs) expression profiling (miR-301a-3p) in both the plasma and the hippocampus in a case of SUDEP due to drug-resistant mesial temporal lobe epilepsy [1]. With these results, the authors supported the idea that miRNAs as an innovative class of biomarkers compatible with an adequate analysis of biospecimens obtained from forensic autopsies [1]. Given the dearth of published data about the relationship of miRNA in SUDEP occurrence, we applaud Dr. (Source: Legal Medicine)
Source: Legal Medicine - April 18, 2018 Category: Forensic Medicine Authors: Fulvio A. Scorza, Ana C. Fiorini, Carla A. Scorza, Josef Finsterer Tags: Letter to Editor Source Type: research
Circulating miRNAs expression profiling in drug-resistant epilepsy: up-regulation of miR-301a-3p in a case of sudden unexpected death
We have very appreciated the letter by F. A. Scorza and colleagues [1] confirming the interest of both clinicians and pathologists on the challenges posed by Sudden Unexpected Death in Epilepsy (SUDEP) [2]. Furthermore, we welcome the courteous questions that give us the opportunity to better explain our point of view on miRNA and SUDEP. (Source: Legal Medicine)
Source: Legal Medicine - April 18, 2018 Category: Forensic Medicine Authors: Maria De Matteis, Giovanni Cecchetto, Giada Munari, Laura Balsamo, Marina Paola Gardiman, Renzo Giordano, Guido Viel, Matteo Fassan Source Type: research
Effects of PCR inhibitors on mRNA expression for human blood identification
Deposited biological stains at the crime scene, such as blood, saliva, and semen, are currently subjected to body fluid identification by serological and enzymatic tests as conventional methods. New approaches using messenger RNA (mRNA) have recently been reported as a useful tool in forensic casework [1 –4]. (Source: Legal Medicine)
Source: Legal Medicine - April 9, 2018 Category: Forensic Medicine Authors: Shusaku Matsumura, Aya Matsusue, Brian Waters, Masayuki Kashiwagi, Kenji Hara, Shin-ichi Kubo Tags: Short Communication Source Type: research
Strangulation of the heart presenting as sudden cardiac death: A deadly but forgotten complication of epicardial pacing device
Strangulation of the heart is a life-threatening yet rarely reported mechanical phenomenon that may occur with epicardial pacing wires in individuals undergoing somatic growth. Cardiac strangulation (CS) develops when epicardial pacemaker wires dislodge and adhere to the outer surface of the heart [1]. Over the passage of time, owing to a size mismatch between the fixed wire length and the dynamically growing heart, an epicardial wire may embed around the heart and progressively compress involved cardiac structures. (Source: Legal Medicine)
Source: Legal Medicine - April 5, 2018 Category: Forensic Medicine Authors: Martin Jan ík, Petr Hejna, Ľubomír Straka, Jozef Krajčovič, František Novomeský Tags: Case Report Source Type: research
Strangulation of the Heart Presenting as Sudden Cardiac Death: A Deadly but Forgotten Complication of Epicardial Pacing Device
Strangulation of the heart is a life-threatening yet rarely reported mechanical phenomenon that may occur with epicardial pacing wires in individuals undergoing somatic growth. Cardiac strangulation (CS) develops when epicardial pacemaker wires dislodge and adhere to the outer surface of the heart [1]. Over the passage of time, owing to a size mismatch between the fixed wire length and the dynamically growing heart, an epicardial wire may embed around the heart and progressively compress involved cardiac structures. (Source: Legal Medicine)
Source: Legal Medicine - April 5, 2018 Category: Forensic Medicine Authors: Martin Jan ík, Petr Hejna, Petr Hejna, Ľubomír Straka, Jozef Krajčovič, František Novomeský Source Type: research
Mutation analysis of short tandem repeats in a population sample from Upper Silesia (southern Poland)
In this study, insertion or deletion of one repetitive unit was observed in 38 of 32,391 meiotic transfers analysed in 953 paternity testing cases. Parentage samples from Upper Silesia (southern Poland) were examined in 2008 –2014 with the use of three commercially available amplification kits: AmpFlSTR Identifiler (Applied Biosystems), PowerPlex 16 HS (Promega) and PowerPlex ESX 17 (Promega). (Source: Legal Medicine)
Source: Legal Medicine - March 31, 2018 Category: Forensic Medicine Authors: Kornelia Dro ździok, Jadwiga Kabiesz, Marcin Tomsia, Rafał Skowronek, Krzysztof Rębała Source Type: research
Non-invasive prenatal paternity testing using cell-free fetal DNA from maternal plasma: DNA isolation and genetic marker studies
In cases like sexual assault, many pregnant women want to confirm the biological father as soon as possible to decide whether to undergo elective termination of pregnancy. The conventional method for prenatal diagnosis of paternity is invasive, such as amniocentesis or chorionic villus sampling [1]. These methods have distinct disadvantages for pregnant women. Apart from the risk of serious complications such as miscarriage [2,3] or congenital malformations [4,5], the stage of pregnancy at which these methods are applicable is late, delaying the decision on pregnancy outcome. (Source: Legal Medicine)
Source: Legal Medicine - March 31, 2018 Category: Forensic Medicine Authors: Shanshan Zhang, Shuyi Han, Maoxiu Zhang, Yunshan Wang Source Type: research
Mutation analysis of short tandem repeats in a population sample from Upper Silesia (southern Poland)
In this study, insertion or deletion of one repetitive unit was observed in 38 of 32391 meiotic transfers analysed in 953 paternity testing cases. Parentage samples from Upper Silesia (southern Poland) were examined in 2008-2014 with the use of three commercially available amplification kits: AmpFlSTR Identifiler (Applied Biosystems), PowerPlex 16 HS (Promega) and PowerPlex ESX 17 (Promega). (Source: Legal Medicine)
Source: Legal Medicine - March 31, 2018 Category: Forensic Medicine Authors: Kornelia Dro ździok, Jadwiga Kabiesz, Marcin Tomsia, Rafał Skowronek, Krzysztof Rębała Source Type: research
Non-invasive prenatal paternity testing using cell-free fetal DNA from maternal plasma: DNA isolation and genetic marker studies
In cases like sexual assault, many pregnant women want to confirm the biological father as soon as possible to decide whether to undergo elective termination of pregnancy. The conventional method for prenatal diagnosis of paternity is invasive, such as amniocentesis or chorionic villus sampling [1]. These methods have distinct disadvantages for pregnant women. Apart from the risk of serious complications such as miscarriage [2,3] or congenital malformations [4,5], the stage of pregnancy at which these methods are applicable is late, delaying the decision on pregnancy outcome. (Source: Legal Medicine)
Source: Legal Medicine - March 31, 2018 Category: Forensic Medicine Authors: Shanshan Zhang, Shuyi Han, Maoxiu Zhang, Yunshan Wang Source Type: research
Forensic parameters for 15 autosomal STRs in Mestizo population from the state of Guerrero (South, Mexico)
In Mexico, most of the population (>90%) is result of admixture after the European contact between Spaniards, Amerindians, and African slaves, principally. They are commonly described as Mestizos, who speak Spanish and live in both urban and rural regions throughout the country. Many studies have been conducted in Mexican-Mestizos to validate the employment of autosomal short tandem repeats (STRs) for human identification purposes [1,2]. However, In Mexico this forensic validation requires studying different populations given the genetic structure demonstrated among Mestizos from different regions [3]. (Source: Legal Medicine)
Source: Legal Medicine - March 30, 2018 Category: Forensic Medicine Authors: G.J. Locia-Aguilar, B. L ópez-Saucedo, S. Deheza-Bautista, O.V. Salado-Beltrán, V.M. Martínez-Sevilla, H. Rangel-Villalobos Tags: Short Communication Source Type: research
Forensic parameters for 15 autosomal STRs in Mestizo population from the State of Guerrero (South, Mexico)
In Mexico, most of the population (> 90 %) is result of admixture after the European contact between Spaniards, Amerindians, and African slaves, principally. They are commonly described as Mestizos, who speak Spanish and live in both urban and rural regions throughout the country. Many studies have been conducted in Mexican-Mestizos to validate the employment of autosomal short tandem repeats (STRs) for human identification purposes [1,2]. However, In Mexico this forensic validation requires studying different populations given the genetic structure demonstrated among Mestizos from different regions [3]. (Source: Legal Medicine)
Source: Legal Medicine - March 30, 2018 Category: Forensic Medicine Authors: G.J. Locia-Aguilar, B. L ópez-Saucedo, S. Deheza-Bautista, O.V. Salado-Beltrán, V.M. Martínez-Sevilla, H. Rangel-Villalobos Source Type: research
Body packing and intra-vaginal body pushing of cocaine: A not-so-rare event
We have read the noteworthy paper by W.hade and Chikhalkar, named “Body packing and intra-vaginal body pushing of Cocaine: A case report” [1]. The study discloses relevant information and clearly describes the internal concealment of drug packages as an ever-changing issue, presenting new challenges to police forces and researchers and raising important medico -legal issues. Despite these aspects, we would like to make a contribution and clarify some issues. (Source: Legal Medicine)
Source: Legal Medicine - March 28, 2018 Category: Forensic Medicine Authors: Simone Cappelletti, Daria Piacentino Tags: Letter to Editor Source Type: research
Body packing and intra-vaginal body pushing of cocaine: a not-so-rare event
We have read the noteworthy paper by W.hade and Chikhalkar, named “Body packing and intra-vaginal body pushing of Cocaine: A case report” [1]. The study discloses relevant information and clearly describes the internal concealment of drug packages as an ever-changing issue, presenting new challenges to police forces and researchers and raising important medico -legal issues. Despite these aspects, we would like to make a contribution and clarify some issues. (Source: Legal Medicine)
Source: Legal Medicine - March 28, 2018 Category: Forensic Medicine Authors: Simone Cappelletti, Daria Piacentino Source Type: research
