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TGFBR2 gene polymorphisms are associated with end-stage kidney disease
Conclusion We suggest that TGF-βR2 polymorphisms (rs764522 and rs3087465) affect the risk of development of ESRD. (Source: Kidney Research and Clinical Practice)
Source: Kidney Research and Clinical Practice - May 30, 2015 Category: Urology & Nephrology Source Type: research

Changes in serum magnesium concentration after use of a proton pump inhibitor in patients undergoing percutaneous coronary intervention
Conclusion Changes in magnesium levels might be subtle after PPI use in patients with normal baseline magnesium values. (Source: Kidney Research and Clinical Practice)
Source: Kidney Research and Clinical Practice - May 20, 2015 Category: Urology & Nephrology Source Type: research

The increased intra-abdominal pressure in acute kidney injury: A cause or an effect?
Publication date: Available online 12 May 2015 Source:Kidney Research and Clinical Practice Author(s): Jung Eun Lee (Source: Kidney Research and Clinical Practice)
Source: Kidney Research and Clinical Practice - May 13, 2015 Category: Urology & Nephrology Source Type: research

Intra-abdominal hypertension does not predict renal recovery or in-hospital mortality in critically ill patients with acute kidney injury
Conclusion Although IAH is prevalent in critically ill patients with AKI, it did not predict AKI prognosis. However, urinary NGAL was found to be a useful predictor of both renal recovery and in-hospital mortality. (Source: Kidney Research and Clinical Practice)
Source: Kidney Research and Clinical Practice - April 30, 2015 Category: Urology & Nephrology Source Type: research

Effect of Aldosterone on Epithelial-to-Mesenchymal Transition of Human Peritoneal Mesothelial Cell
Conclusion Aldosterone induced EMT in HPMC by acting through mineralocorticoid receptor. Aldosterone-induced generation of ROS followed by an activation of ERK & p38 MAPK served as one of the mechanisms of aldosterone-induced EMT of HPMC. (Source: Kidney Research and Clinical Practice)
Source: Kidney Research and Clinical Practice - April 26, 2015 Category: Urology & Nephrology Source Type: research

Non-immunologic targets of immunosuppressive agents in podocytes
Publication date: Available online 9 April 2015 Source:Kidney Research and Clinical Practice Author(s): Tae-Hyun Yoo , Alessia Fornoni Proteinuria is a characteristic finding in glomerular diseases and is closely associated with renal outcomes. In addition, therapeutic interventions that reduce proteinuria improves renal prognosis. Accumulating evidence has demonstrated that podocytes act as key modulators of glomerular injury and proteinuria. Podocytes, or glomerular visceral epithelial cells, are highly specialized and differentiated cells and inter-digitated foot process with neighboring podocytes are bridged by a...
Source: Kidney Research and Clinical Practice - April 10, 2015 Category: Urology & Nephrology Source Type: research

Fibrillary glomerulonephritis without immunoglobulin deposits combined with chronic inflammatory demyelinating polyneuropathy
Publication date: Available online 26 March 2015 Source:Kidney Research and Clinical Practice Author(s): Woo Kyung Sung , Jin Uk Jeong , Ki Tae Bang , Jong Ho Shin , Ji Hyung Yoo , Nak Min Kim , Jun Hyung Park , Joo Heon Kim A 58-yr-old man presented with leg edema and subacute weakness of his bilateral lower extremities. Urinary and serum immunoelectrophoresis revealed the presence of lambda-type Bence Jones proteins. He was ultimately diagnosed with monoclonal gammopathy of undetermined significance. A renal biopsy specimen showed fibrillary glomerulonephritis, which was randomly arranged as 12–20-nm nonbra...
Source: Kidney Research and Clinical Practice - March 27, 2015 Category: Urology & Nephrology Source Type: research

Change in serum magnesium concentration after use of a proton pump inhibitor in patients undergoing percutaneous coronary intervention
Conclusion The change of magnesium might be subtle after PPI use in patients with baseline normal value of magnesium. (Source: Kidney Research and Clinical Practice)
Source: Kidney Research and Clinical Practice - March 27, 2015 Category: Urology & Nephrology Source Type: research

Does hypokalemia contribute to acute kidney injury in chronic laxative abuse?
Publication date: Available online 27 March 2015 Source:Kidney Research and Clinical Practice Author(s): Eun-Young Lee , Hyaejin Yoon , Joo-Hark Yi , Woon-Yong Jung , Sang-Woong Han , Ho-Jung Kim Prolonged hypokalemia from chronic laxative abuse is recognized as the cause of chronic tubulointerstitial disease, known as ‘hypokalemic nephropathy’, but it is not clear whether it contributes to acute kidney injury (AKI). A 42-year-old woman with a previous history of chronic kidney disease as a result of chronic laxative abuse from a purging type of anorexia nervosa (AN-P) developed an anuric AKI requiring hemodi...
Source: Kidney Research and Clinical Practice - March 27, 2015 Category: Urology & Nephrology Source Type: research

A rare case of hyperoxaluria presenting with acute liver injury and stone-free kidney injury
Publication date: Available online 27 March 2015 Source:Kidney Research and Clinical Practice Author(s): Si-eun Kim , Seon-Jae Kim , Seong Taek Chu , Seung Hee Yang , Yon Su Kim , Ran-hui Cha A 49-year-old woman visited the clinic because of acute hepatitis and acute kidney injury with decreased urine output presenting microscopic hematuria and proteinuria. An abdominal computed tomography revealed a localized, hypo-attenuated lesion in a hepatic lateral segment, and kidney biopsy showed oxalate crystal deposition with tubular necrosis. In addition, the patient's 24-hour urinary excretion of oxalate was increased...
Source: Kidney Research and Clinical Practice - March 27, 2015 Category: Urology & Nephrology Source Type: research

Genetic predisposition of donors affects the allograft outcome in kidney transplantation: Single-nucleotide polymorphism of aquaporin-11
Conclusion A donor-derived, not recipient-derived, genetic AQP11 polymorphism has different effects on graft outcome. Thus, the genetic influence from donors should be carefully considered for proper management of allografts after kidney transplantation. (Source: Kidney Research and Clinical Practice)
Source: Kidney Research and Clinical Practice - March 18, 2015 Category: Urology & Nephrology Source Type: research

Relationship between pulmonary hypertension, peripheral vascular calcification, and major cardiovascular events in dialysis patients
Conclusion The prevalence of PHT was higher in HD patients and was associated with higher rates of major cardiovascular events. Severe VCs are thought to be an independent risk factor for predicting PHT in ESRD patients. Therefore, in dialysis patients with PHT, careful attention should be paid to the presence of VCs and the occurrence of major cardiovascular events. (Source: Kidney Research and Clinical Practice)
Source: Kidney Research and Clinical Practice - March 18, 2015 Category: Urology & Nephrology Source Type: research

Effect of acute intradialytic strength physical exercise on oxidative stress and inflammatory responses in hemodialysis patients
Conclusion These data suggest that acute intradialytic strength physical exercise was unable to reduce oxidative stress and inflammation, and in addition, it seems to reduce plasma SOD levels, which could exacerbate the oxidative stress in HD patients. (Source: Kidney Research and Clinical Practice)
Source: Kidney Research and Clinical Practice - March 18, 2015 Category: Urology & Nephrology Source Type: research

Hyperphosphatemia is associated with patency loss of arteriovenous fistula after 1 year of hemodialysis
Conclusion Various factors were associated with the development of patency loss of AVF as hemodialysis duration differed, and a preventive role of hyperphosphatemia control in AVF survival needs further clinical study. (Source: Kidney Research and Clinical Practice)
Source: Kidney Research and Clinical Practice - March 18, 2015 Category: Urology & Nephrology Source Type: research

Management of chronic kidney disease–mineral and bone disorder: Korean working group recommendations
Publication date: Available online 24 February 2015 Source:Kidney Research and Clinical Practice Author(s): Eunah Hwang , Bum Soon Choi , Kook-Hwan Oh , Young Joo Kwon , Gheun-Ho Kim For Korean dialysis patients, chronic kidney disease–mineral bone disorder is a serious burden because of cardiovascular calcification and mortality. However, recent epidemiologic data have demonstrated that many patients undergoing maintenance hemodialysis are out of the target ranges of serum calcium, phosphorus, and intact parathyroid hormone. Thus, we felt the necessity for the development of practical recommendations to treat a...
Source: Kidney Research and Clinical Practice - March 18, 2015 Category: Urology & Nephrology Source Type: research