A rare case of hyperoxaluria presenting with acute liver injury and stone-free kidney injury

Publication date: Available online 27 March 2015 Source:Kidney Research and Clinical Practice Author(s): Si-eun Kim , Seon-Jae Kim , Seong Taek Chu , Seung Hee Yang , Yon Su Kim , Ran-hui Cha A 49-year-old woman visited the clinic because of acute hepatitis and acute kidney injury with decreased urine output presenting microscopic hematuria and proteinuria. An abdominal computed tomography revealed a localized, hypo-attenuated lesion in a hepatic lateral segment, and kidney biopsy showed oxalate crystal deposition with tubular necrosis. In addition, the patient's 24-hour urinary excretion of oxalate was increased. Her renal function and liver injury improved after several sessions of hemodialysis and urinary oxalate excretion was normalized. Major mutations in primary hyperoxaluria have not been proven. A full sequencing of target genes may be helpful to diagnose a rare form of primary hyperoxaluria.
Source: Kidney Research and Clinical Practice - Category: Urology & Nephrology Source Type: research