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TLR4 Antagonist and Obesity associated Kidney disease: Where should we go from here?
Publication date: Available online 29 November 2014 Source:Kidney Research and Clinical Practice Author(s): Quaisar Ali (Source: Kidney Research and Clinical Practice)
Source: Kidney Research and Clinical Practice - November 30, 2014 Category: Urology & Nephrology Source Type: research

Diagnostic accuracy of urine dipstick for proteinuria in older outpatients
Conclusion Urine dipstick test can be used for screening in older outpatients with ACR ≥300mg/g or PCR as the reference standard for proteinuria. However, we cannot recommend the test as a screening tool with ACR ≥30mg/g as the reference owing to its low sensitivity. (Source: Kidney Research and Clinical Practice)
Source: Kidney Research and Clinical Practice - November 29, 2014 Category: Urology & Nephrology Source Type: research

Idiopathic erythrocytosis in a patient on chronic hemodialysis
Publication date: Available online 27 November 2014 Source:Kidney Research and Clinical Practice Author(s): Dong Hyun Lee , Ji Hye Min , Sang Byung Bae , Hyo Wook Gil , Jong Oh Yang , Eun Young Lee , Sae Yong Hong A 78-year-old man on hemodialysis presented to our hospital with erythrocytosis. He had started hemodialysis 4 years previously, with a hemoglobin level of 9.8g/dL, and was administered erythropoiesis stimulating agents and ferrous sulfate. Two years previously, his hemoglobin level increased to 14.5g/dL and the treatment for anemia was discontinued. He continued hemodialysis thrice weekly; however, th...
Source: Kidney Research and Clinical Practice - November 28, 2014 Category: Urology & Nephrology Source Type: research

MYH9 nephropathy
Publication date: Available online 28 November 2014 Source:Kidney Research and Clinical Practice Author(s): Taehoon Oh , Hyun Jung Seo , Kyu Taek Lee , Han Jo Kim , Hwi Jun Kim , Ji-Hye Lee , Hae Il Cheong , Eun Young Lee MYH9-related disorder is an autosomal dominant disease caused by a mutation in the MYH9 gene, which encodes nonmuscle myosin heavy chain IIA (NMMHC-IIA). This disease is characterized by giant platelets, thrombocytopenia, granulocyte inclusion bodies, proteinuria, and high-pitch sensorineural deafness. Nephropathy has been observed in 30% of patients with MYH9-related disorder. The characteris...
Source: Kidney Research and Clinical Practice - November 28, 2014 Category: Urology & Nephrology Source Type: research

Reanalysis of membranoproliferative glomerulonephritis patients according to the new classification: a multicenter study
Conclusion Complement-mediated glomerulonephritis was present in 4.3% of patients previously diagnosed with MPGN. (Source: Kidney Research and Clinical Practice)
Source: Kidney Research and Clinical Practice - November 27, 2014 Category: Urology & Nephrology Source Type: research

The etiology and outcomes of anuria in acute kidney injury: a single center study
Conclusions Anuric AKI is common, with sepsis as the main etiological insult, and is associated with adverse outcomes among RRT-requiring AKI. (Source: Kidney Research and Clinical Practice)
Source: Kidney Research and Clinical Practice - November 26, 2014 Category: Urology & Nephrology Source Type: research

A case of primary aldosteronism combined with acquired nephrogenic diabetes insipidus
We report a rare case of a 37-year-old man who complained of general weakness and polyuria. He was diagnosed with aldosterone-producing adrenal adenoma and nephrogenic diabetes insipidus. Aldosterone enhances the secretion of potassium in the collecting duct, which can lead to hypokalemia. By contrast, nephrogenic diabetes insipidus, which manifests as polyuria and polydipsia, can occur in several clinical conditions such as acquired tubular disease and those attributed to toxins and congenital causes. Among them, hypokalemia can also damage tubular structures in response to vasopressin. The patient’s urine output was &a...
Source: Kidney Research and Clinical Practice - November 26, 2014 Category: Urology & Nephrology Source Type: research

Toxic epidermal necrolysis associated with deflazacort therapy with nephrotic syndrome
This report describes two cases of TEN, associated with deflazacort (DFZ), in two boys, aged 4 years and 14 years, with nephrotic syndrome (NS). The 14-year-old male teenager received DFZ following NS relapse. After 17 days, pruritic papules appeared on the lower extremities. Another case involved a 4-year-old boy receiving DFZ and enalapril. After a 41-day DFZ treatment period, erythematous papules appeared on the palms and soles. Within 3 days, both boys developed widespread skin lesions (>50%) and were admitted to the intensive care unit for resuscitative and supportive treatment. The patients showed improvement ...
Source: Kidney Research and Clinical Practice - November 20, 2014 Category: Urology & Nephrology Source Type: research

Anticoagulants and acute kidney injury: clinical and pathology considerations
Publication date: Available online 18 November 2014 Source:Kidney Research and Clinical Practice Author(s): Sergey V. Brodsky We have recently identified a new clinical syndrome in patients receiving warfarin for anticoagulation therapy. This syndrome has been named warfarin-related nephropathy (WRN), and patients with chronic kidney disease (CKD) appear to be particularly susceptible. WRN is defined as an acute increase in international normalized ratio (INR) to > 3.0, followed by evidence of acute kidney injury (AKI) within 1 week of the INR increase. AKI was defined as a sustained increase in serum creatinin...
Source: Kidney Research and Clinical Practice - November 18, 2014 Category: Urology & Nephrology Source Type: research

Mechanisms of phytoestrogen biochanin A-induced vasorelaxation in renovascular hypertensive rats
Conclusion These results suggest that the enhanced relaxation caused by biochanin A in aortic rings from hypertensive rats is endothelium dependent. Vascular smooth muscle K+ channels may be involved in biochanin A-induced relaxation in aortae from hypertensive and normotensive rats. In addition, an endothelium-derived activation of voltage-dependent K+ channels contributes, at least in part, to the relaxant effect of biochanin A in renovascular hypertension. (Source: Kidney Research and Clinical Practice)
Source: Kidney Research and Clinical Practice - November 13, 2014 Category: Urology & Nephrology Source Type: research

Association between mortality and abdominal aortic calcification and their progression in hemodialysis patients
Publication date: Available online 11 November 2014 Source:Kidney Research and Clinical Practice Author(s): Won Suk An (Source: Kidney Research and Clinical Practice)
Source: Kidney Research and Clinical Practice - November 12, 2014 Category: Urology & Nephrology Source Type: research

Ipsilateral leg swelling after renal transplantation as an alarming sign of Iliac vein stenosis
Publication date: Available online 11 November 2014 Source:Kidney Research and Clinical Practice Author(s): Ju Hyeon Kim , Seong Man Bae , Su-Kil Park Iliac vein stenosis is a rare vascular complication of renal transplantation that may compromise allograft function if not recognized and corrected in a timely fashion. Because chronic venous stenosis may remain undiagnosed for several years, a high index of suspicion should be maintained until diagnosing this rare disease. A 56-year-old renal transplant recipient presented with unilateral leg swelling and renal dysfunction 16 years after transplantation. Computed tom...
Source: Kidney Research and Clinical Practice - November 12, 2014 Category: Urology & Nephrology Source Type: research

Resolution of uremic tumoral calcinosis in a patient on peritoneal dialysis with long-term low-calcium dialysate treatment
Publication date: Available online 6 November 2014 Source:Kidney Research and Clinical Practice Author(s): Yaerim Kim , Eunah Hwang , Sungbae Park Tumoral calcinosis is a rare complication in uremic patients. An in-depth review of published literature suggests that most patients with uremic tumoral calcinosis do not respond to medical treatment. Here, we report the case of a patient on peritoneal dialysis who presented with infected multifocal masses on both hip joints and was successfully treated by medical intervention. The patient was diagnosed with uremic tumoral calcinosis by physical examination and radiologic...
Source: Kidney Research and Clinical Practice - November 6, 2014 Category: Urology & Nephrology Source Type: research

Resistive index as a predictor of acute kidney injury caused by an angiotensin converting enzyme inhibitor or angiotensin II receptor blocker in chronic kidney disease patients
Conclusion RI≥0.80 on the renal duplex ultrasonography may be a helpful predictor for AKI in CKD patients who are prescribed an ACE inhibitor or ARB. (Source: Kidney Research and Clinical Practice)
Source: Kidney Research and Clinical Practice - November 3, 2014 Category: Urology & Nephrology Source Type: research

Clinical usefulness of kidney biopsy in liver transplant recipients with renal impairment
Conclusion Kidney biopsy is a safe and effective method for determining the cause of renal impairment after liver transplantation. Management of patients based on the result of kidney biopsy may improve renal outcomes. (Source: Kidney Research and Clinical Practice)
Source: Kidney Research and Clinical Practice - November 3, 2014 Category: Urology & Nephrology Source Type: research