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Thrombotic microangiopathy resulting from neglected blood pressure control
Publication date: June 2014 Source:Kidney Research and Clinical Practice, Volume 33, Issue 2 Author(s): Jeong Sang Ku , Won Kim , Sik Lee , Myoung Jae Kang , Sung Kwang Park , Kyung Pyo Kang Hypertensive nephrosclerosis is usually associated with chronic hypertension, which increases the risk of progressive renal disease. Among the causes of malignant hypertension, thrombotic microangiopathy is complicated and is associated with renal dysfunction at the time of diagnosis. In this case, a young man with hypertension presented with renal failure and thrombocytopenia in the emergency department. This case emphasizes...
Source: Kidney Research and Clinical Practice - November 3, 2014 Category: Urology & Nephrology Source Type: research

The association between mortality and abdominal aortic calcification and relation between its progression and serum calcium concentration in chronic hemodialysis patients
Conclusion Patients with an AAC score of>8 at baseline seem to be at higher risk of mortality during follow-up. Of the serum variables examined, such as corrected calcium, phosphate, and corrected calcium×phosphate, corrected calcium was found to be marginally associated with AAC progression. However, a larger-scale prospective study is required to confirm our findings. (Source: Kidney Research and Clinical Practice)
Source: Kidney Research and Clinical Practice - November 3, 2014 Category: Urology & Nephrology Source Type: research

Excess mortality among patients on dialysis: Comparison with the general population in Korea
Conclusion The SMR among Korean ESRD patients is likely to be higher than in other countries. Further evaluation is needed to attempt to improve the outcomes. (Source: Kidney Research and Clinical Practice)
Source: Kidney Research and Clinical Practice - November 3, 2014 Category: Urology & Nephrology Source Type: research

Development of intestinal ischemia/reperfusion-induced acute kidney injury in rats with or without chronic kidney disease: Cytokine/chemokine response and effect of α-melanocyte-stimulating hormone
Conclusion Both the functional parameters and the cytokine/chemokine response are as dramatic when AKI is superimposed onto CKD as onto non-CKD. No convincing protective effect of α-MSH was detected. (Source: Kidney Research and Clinical Practice)
Source: Kidney Research and Clinical Practice - November 3, 2014 Category: Urology & Nephrology Source Type: research

Cyst growth, polycystins, and primary cilia in autosomal dominant polycystic kidney disease
Publication date: June 2014 Source:Kidney Research and Clinical Practice, Volume 33, Issue 2 Author(s): Seung Hun Lee , Stefan Somlo The primary cilium of renal epithelia acts as a transducer of extracellular stimuli. Polycystin (PC)1 is the protein encoded by the PKD1 gene that is responsible for the most common and severe form of autosomal dominant polycystic kidney disease (ADPKD). PC1 forms a complex with PC2 via their respective carboxy-terminal tails. Both proteins are expressed in the primary cilia. Mutations in either gene affect the normal architecture of renal tubules, giving rise to ADPKD. PC1 has been pro...
Source: Kidney Research and Clinical Practice - November 3, 2014 Category: Urology & Nephrology Source Type: research

Experimental evidence that preexisting chronic kidney disease is a risk factor for acute kidney injury
Publication date: June 2014 Source:Kidney Research and Clinical Practice, Volume 33, Issue 2 Author(s): Kwon Moo Park (Source: Kidney Research and Clinical Practice)
Source: Kidney Research and Clinical Practice - November 3, 2014 Category: Urology & Nephrology Source Type: research

Performance comparison of estimated glomerular filtration rate equations
Publication date: September 2014 Source:Kidney Research and Clinical Practice, Volume 33, Issue 3 (Source: Kidney Research and Clinical Practice)
Source: Kidney Research and Clinical Practice - November 3, 2014 Category: Urology & Nephrology Source Type: research

Improvement of Erdheim-Chester disease-related renal failure after treatment with anakinra
We report the case of an elderly patient with ECD and severe involvement of the heart and kidneys who was successfully treated with anakinra. (Source: Kidney Research and Clinical Practice)
Source: Kidney Research and Clinical Practice - November 3, 2014 Category: Urology & Nephrology Source Type: research

Nephrotic syndrome complicated with portal, splenic, and superior mesenteric vein thrombosis
Publication date: September 2014 Source:Kidney Research and Clinical Practice, Volume 33, Issue 3 Author(s): Bong Soo Park , Sihyung Park , Kyubok Jin , Gibok Choi , Kang Min Park , Kyeong Min Jo , Yang Wook Kim Thromboembolism is a major complication of nephrotic syndrome. Renal vein thrombosis and deep vein thrombosis are relatively common, especially in membranous nephropathy. However, the incidence of portal vein and superior mesenteric vein (SMV) thrombosis in patients with nephrotic syndrome is very rare. To date, several cases of portal vein thrombosis treated by anticoagulation therapy, not by thrombolyt...
Source: Kidney Research and Clinical Practice - November 3, 2014 Category: Urology & Nephrology Source Type: research

Remission of secondary membranous nephropathy in a patient with Kimura disease after surgical resection
Publication date: September 2014 Source:Kidney Research and Clinical Practice, Volume 33, Issue 3 Author(s): Sunhwa Lee , Yong Jin Yi , Hyung Ah Jo , Hyuk Huh , Kyung-Hwan Kim , Dong Ki Kim , Hajeong Lee Kimura disease (KD) is an eosinophilic, granulomatous, benign, chronic inflammatory disease with an unknown etiology. A 33-year-old woman visited our hospital because of a palpable, left subclavian mass, a left scapulo-anterior pseudoaneurysm, and nephrotic syndrome. Her subclavian lymph node biopsy examination result was consistent with KD, and results of a renal biopsy indicated secondary membranous nephropath...
Source: Kidney Research and Clinical Practice - November 3, 2014 Category: Urology & Nephrology Source Type: research

A new connecting technique in partial replantation of a ruptured peritoneal dialysis catheter
Publication date: September 2014 Source:Kidney Research and Clinical Practice, Volume 33, Issue 3 Author(s): Yaeni Kim , Prashant C. Dheerendra , Yong-Soo Kim Peritoneal dialysis catheter ruptures have been managed by immediate removal and subsequent reinsertion of the catheter which inevitably entails interruption in peritoneal dialysis and a need for vascular access. A 36-year-old man on continuous ambulatory peritoneal dialysis complaining of dialysate leakage was found to have a small rupture near the outer cuff of the peritoneal dialysis catheter. Rather than employing the traditional method of exchanging the w...
Source: Kidney Research and Clinical Practice - November 3, 2014 Category: Urology & Nephrology Source Type: research

Emphysematous pyelonephritis initially presenting as a spontaneous subcapsular hematoma in a diabetic patient
We report a case of EPN that initially presented as spontaneous SCH. The patient was admitted for left flank pain, and initial computed tomography revealed SCH without any air shadows. Laboratory findings and clinical symptoms suggested the presence of urinary tract infection and the patient was started on antibiotics. Fever developed 24 hours after admission. On follow-up computed tomography 7 days later, EPN was newly observed, and a percutaneous drain was inserted. Blood, urine, and drainage fluid cultures all revealed growth of extended-spectrum β-lactamase-negative Escherichia coli. (Source: Kidney Research and Clinical Practice)
Source: Kidney Research and Clinical Practice - November 3, 2014 Category: Urology & Nephrology Source Type: research

Comparison of exit site infection and peritonitis incidences between povidone-iodine and normal saline use for chronic exit site care in peritoneal dialysis patients
Conclusion Exit site care using normal saline did not increase the incidence of exit site infection and peritonitis. Therefore, normal saline may be an alternative treatment for exit site care in patients receiving PD. (Source: Kidney Research and Clinical Practice)
Source: Kidney Research and Clinical Practice - November 3, 2014 Category: Urology & Nephrology Source Type: research

Clinicopathological role of kidney injury molecule-1 in immunoglobulin A nephropathy
Conclusion In patients with IgA nephropathy, urinary KIM-1 has a significant correlation with histopathologic severity. (Source: Kidney Research and Clinical Practice)
Source: Kidney Research and Clinical Practice - November 3, 2014 Category: Urology & Nephrology Source Type: research

Chronic renal failure induces cell death in rat hippocampal CA1 via upregulation of αCaMKII/NR2A synaptic complex and phosphorylated GluR1-containing AMPA receptor cascades
Conclusion These hippocampal CA1 neuronal vulnerability may be responsible for memory dysfunction after CRF as mediated by an increase in NR2A-containing NMDA receptors bound to αCaMKII and subsequent activation of GluR1-containing AMPA receptors caused by the phosphorylation of GluR1 at ser831. (Source: Kidney Research and Clinical Practice)
Source: Kidney Research and Clinical Practice - November 3, 2014 Category: Urology & Nephrology Source Type: research