Mechanisms of phytoestrogen biochanin A-induced vasorelaxation in renovascular hypertensive rats

Conclusion These results suggest that the enhanced relaxation caused by biochanin A in aortic rings from hypertensive rats is endothelium dependent. Vascular smooth muscle K+ channels may be involved in biochanin A-induced relaxation in aortae from hypertensive and normotensive rats. In addition, an endothelium-derived activation of voltage-dependent K+ channels contributes, at least in part, to the relaxant effect of biochanin A in renovascular hypertension.
Source: Kidney Research and Clinical Practice - Category: Urology & Nephrology Source Type: research