Fibrillary glomerulonephritis without immunoglobulin deposits combined with chronic inflammatory demyelinating polyneuropathy

Publication date: Available online 26 March 2015 Source:Kidney Research and Clinical Practice Author(s): Woo Kyung Sung , Jin Uk Jeong , Ki Tae Bang , Jong Ho Shin , Ji Hyung Yoo , Nak Min Kim , Jun Hyung Park , Joo Heon Kim A 58-yr-old man presented with leg edema and subacute weakness of his bilateral lower extremities. Urinary and serum immunoelectrophoresis revealed the presence of lambda-type Bence Jones proteins. He was ultimately diagnosed with monoclonal gammopathy of undetermined significance. A renal biopsy specimen showed fibrillary glomerulonephritis, which was randomly arranged as 12–20-nm nonbranching fibrils in the basement membranes. Immunofluorescence studies were negative for immunoglobulin G, immunoglobulin M, immunoglobulin A, C3, and kappa light chains in the capillary walls and mesangial areas. A Congo red stain for amyloid was negative. Electromyography and nerve conduction velocity examinations results were compatible with the presence of demyelinating polyneuropathy. This case showed a rare combination of fibrillary glomerulonephritis, without Ig deposition, and monoclonal gammopathy of undetermined significance combined with chronic inflammatory demyelinating polyneuropathy.
Source: Kidney Research and Clinical Practice - Category: Urology & Nephrology Source Type: research