Towards use of MRI-guided ultrasound for treating cerebral vasospasm
Abstract
Cerebral vasospasm is a major cause of morbidity and mortality in patients with subarachnoid hemorrhage (SAH), causing delayed neurological deficits in as many as one third of cases. Existing therapy targets induction of cerebral vasodilation through use of various drugs and mechanical means, with a range of observed efficacy. Here, we perform a literature review supporting our hypothesis that transcranially delivered ultrasound may have the ability to induce therapeutic cerebral vasodilation and, thus, may one day be used therapeutically in the context of SAH. Prior studies demonstrate that ul...
Source: Journal of Therapeutic Ultrasound - February 29, 2016 Category: Radiology Source Type: research
Incisionless transcranial MR-guided focused ultrasound in essential tremor: cerebellothalamic tractotomy
Conclusions
CTT with MRgFUS was shown to be an effective and safe approach for patients with therapy-refractory essential tremor, combining neurological function sparing with precise targeting and the possibility to treat patients bilaterally. (Source: Journal of Therapeutic Ultrasound)
Source: Journal of Therapeutic Ultrasound - February 13, 2016 Category: Radiology Source Type: research
Minimizing eddy currents induced in the ground plane of a large phased-array ultrasound applicator for echo-planar imaging-based MR thermometry
Conclusions
We demonstrated that segmenting the transducer ground plane into a star pattern reduces eddy currents to a level wherein multi-plane EPI for accurate MR thermometry in tcMRgFUS is feasible. (Source: Journal of Therapeutic Ultrasound)
Source: Journal of Therapeutic Ultrasound - February 3, 2016 Category: Radiology Source Type: research
Renal sympathetic denervation using MR-guided high-intensity focused ultrasound in a porcine model
Conclusions
Performing renal denervation non-invasively with MRgHIFU was shown to be both safe and effective as determined by norepinephrine levels in a porcine model. This approach may be a promising alternative to catheter-based strategies. (Source: Journal of Therapeutic Ultrasound)
Source: Journal of Therapeutic Ultrasound - February 3, 2016 Category: Radiology Source Type: research
Focused ultrasound-aided immunomodulation in glioblastoma multiforme: a therapeutic concept
In conclusion, it is increasingly apparent that no single treatment modality will triumph on GBM. The reviewed FUS-induced immunomodulation effects can be harnessed to current and developing immunotherapy approaches. Together, these may overcome GBM-induced immune-evasion and generate a clinically relevant anti-tumor immune response. (Source: Journal of Therapeutic Ultrasound)
Source: Journal of Therapeutic Ultrasound - January 22, 2016 Category: Radiology Source Type: research
A review of ablative techniques in the treatment of breast fibroadenomata
Conclusion
Minimally invasive ablative techniques like HIFU, cryo-ablation and laser ablation are promising in the treatment of breast FAD. Future trials should be randomised and contain larger numbers of patients to determine the effectiveness of ablative techniques with more precision. (Source: Journal of Therapeutic Ultrasound)
Source: Journal of Therapeutic Ultrasound - January 19, 2016 Category: Radiology Source Type: research
Non-invasive magnetic resonance-guided high intensity focused ultrasound ablation of a vascular malformation in the lower extremity: a case report
Conclusions
In conclusion, we reported a successful non-invasive treatment of a vascular malformation with MR-HIFU in a clinical patient including long-term follow-up data for the first time. The patient reported qualitatively sustained pain reduction up to 13 months post treatment. (Source: Journal of Therapeutic Ultrasound)
Source: Journal of Therapeutic Ultrasound - December 30, 2015 Category: Radiology Source Type: research
Magnetic resonance-guided motorized transcranial ultrasound system for blood-brain barrier permeabilization along arbitrary trajectories in rodents
Conclusions
Our system offers the unique possibility to move the transducer within a high magnetic field preclinical MRI scanner, thus enabling the delivery of large molecules to virtually any rodent brain area in a non-invasive manner. It results in time-saving and reproducibility and could be used to either deliver drugs over large parts of the brain or test different acoustic conditions on the same animal during the same session, therefore reducing physiological variability. (Source: Journal of Therapeutic Ultrasound)
Source: Journal of Therapeutic Ultrasound - December 24, 2015 Category: Radiology Source Type: research
Ultrasound-guided trans-rectal high-intensity focused ultrasound (HIFU) for advanced cervical cancer ablation is feasible: a case report
Conclusion
Intracavitary HIFU is a potentially safe procedure for the treatment of cervical cancer and able to provide symptomatic improvement in the palliative setting. (Source: Journal of Therapeutic Ultrasound)
Source: Journal of Therapeutic Ultrasound - December 18, 2015 Category: Radiology Source Type: research
Application of acoustic droplet vaporization in ultrasound therapy
Abstract
Microbubbles have been used widely both in the ultrasonic diagnosis to enhance the contrast of vasculature and in ultrasound therapy to increase the bioeffects induced by bubble cavitation. However, due to their large size, the lifetime of microbubbles in the circulation system is on the order of minutes, and they cannot penetrate through the endothelial gap to enter the tumor. In an acoustic field, liquefied gas nanoparticles may be able to change the state and become the gas form in a few cycles of exposure without significant heating effects. Such a phenomenon is called as acoustic droplet v...
Source: Journal of Therapeutic Ultrasound - November 11, 2015 Category: Radiology Source Type: research
Sonoporation efficacy on SiHa cells in vitro at raised bath temperatures—experimental validation of a prototype sonoporation device
Conclusions
Bath temperature did not impact the efficacy of sonoporation treatment on SiHa cells in vitro. The prototype device was found to be suitable for performing sonoporation on adherent cell cultures and will reduce the time and expertise required for conducting sonoporation experiments on adherent cell cultures in the future. (Source: Journal of Therapeutic Ultrasound)
Source: Journal of Therapeutic Ultrasound - November 6, 2015 Category: Radiology Source Type: research
Quantitative assessment of damage during MCET: a parametric study in a rodent model
Conclusions
Ultrasound parameters and administration of microbubbles directly influence lesion characteristics such as microlesion density and macrolesion dimension. For lesion generation planning, control of MCET is crucial, especially when targeting larger pre-clinical models. (Source: Journal of Therapeutic Ultrasound)
Source: Journal of Therapeutic Ultrasound - October 16, 2015 Category: Radiology Source Type: research
Deep Bleeder Acoustic Coagulation (DBAC)—part II: in vivo testing of a research prototype system
Conclusions
While not meeting all in vivo objectives, the overall performance of the DBAC applicator was positive. In particular, D&L automation workflow was verified during each of the tests, with processing times well under specified (10 min) limits, and all bleeder branches were detected and localized. Further, gross necropsy and tissue examination confirmed that the HIFU thermal lesions were coincident with the target vessel locations in over 90 % of the multi-array dosing treatments. The SFA/DFA bleeder models selected, and the protocols used, were the most suitable practical model options ...
Source: Journal of Therapeutic Ultrasound - September 24, 2015 Category: Radiology Source Type: research
Deep bleeder acoustic coagulation (DBAC)—Part I: development and in vitro testing of a research prototype cuff system
Abstract
Background
Bleeding from limb injuries is a leading cause of death on the battlefield, with deep wounds being least accessible. High-intensity focused ultrasound (HIFU) has been shown capable of coagulation of bleeding (cautery). This paper describes the development and refereed in vitro evaluation of an ultrasound (US) research prototype deep bleeder acoustic coagulation (DBAC) cuff system for evaluating the potential of DBAC in the battlefield. The device had to meet quantitative performance metrics on automated operation, therapeutic heating, blee...
Source: Journal of Therapeutic Ultrasound - September 18, 2015 Category: Radiology Source Type: research
T2-based temperature monitoring in abdominal fat during MR-guided focused ultrasound treatment of patients with uterine fibroids
Conclusions
Our results demonstrate the feasibility and importance of monitoring near-field heating in fatty tissues. The implementation of near-field monitoring between sonications can shorten treatments by reducing the cooling time. It can help improve safety by avoiding excessive heating in the near field. (Source: Journal of Therapeutic Ultrasound)
Source: Journal of Therapeutic Ultrasound - September 11, 2015 Category: Radiology Source Type: research
